Aminokrovin (Solution) Instructions for Use

ATC Code

B05BA04 (Protein hydrolysates)

Clinical-Pharmacological Group

Agent for parenteral nutrition – amino acid and electrolyte solution

Pharmacotherapeutic Group

Parenteral nutrition agent, amino acid

Pharmacological Action

Amino acid solutions for parenteral nutrition provide the body with substrates for protein synthesis.

The administration of all amino acids necessary for protein synthesis (including essential, conditionally essential, and non-essential amino acids) ensures high nutritional efficiency and reduces the metabolic burden on the body associated with protein synthesis.

In addition to amino acids, parenteral nutrition preparations may include minerals, Dextrose, xylitol, as well as lipids.

Minerals are necessary to maintain water-electrolyte and acid-base balance.

As an energy source, amino acid solutions for parenteral nutrition may contain dextrose, xylitol, sorbitol, which are involved in the processes of glycolysis and gluconeogenesis.

Fat emulsion is a source of energy and essential fatty acids.

Indications

For parenteral nutrition in inpatient and outpatient settings to cover the daily requirement of patients for amino acids, electrolytes, and fluid during parenteral nutrition in patients with a catabolic state ranging from moderate to severe in cases where enteral nutrition is impossible, insufficient, or contraindicated, as well as in combination with it.

Parenteral nutrition agents should be used strictly in accordance with the indications in the medical instructions for use.

ICD codes

Dosage Regimen

Administer intravenously by drip infusion.

The standard dosage for adults is 30-35 ml/kg/day, providing approximately 0.2-0.25 g of nitrogen per kg of body weight.

Infuse at a rate of 40-60 drops per minute to ensure proper metabolic utilization and minimize adverse effects.

Adjust the total daily volume based on the patient’s clinical status, metabolic needs, and fluid tolerance.

For central venous administration, ensure strict aseptic technique.

Alternatively, using a system for blood and solution transfusion, the solution can be administered through a tube into the stomach or small intestine for enteral access.

Do not mix with other solutions in the same infusion set unless compatibility is confirmed.

Monitor the infusion site regularly for signs of phlebitis or thrombosis.

During therapy, regularly monitor water-electrolyte balance, acid-base status, blood glucose, and liver function.

Adverse Reactions

From the immune system allergic reactions.

From the cardiovascular system phlebitis, thrombosis.

From the respiratory system bronchospasm.

From the digestive system nausea, vomiting.

From the urinary system renal aminoacidosis.

General disorders chills, redness.

Contraindications

General for parenteral nutrition: severe circulatory disorders (collapse and shock); pronounced tissue hypoxia; overhydration; water-electrolyte balance disorders; pulmonary edema; decompensated heart failure, severe renal failure; acute period of traumatic brain injury; coma or impaired brain functions that may cause a comatose state.

Before prescribing a parenteral nutrition drug, the contraindications for its use in a particular patient should be carefully studied.

With caution

Patients with increased plasma osmolarity, heart failure, hepatic and/or renal failure.

In children and adolescents under 18 years of age, only those parenteral nutrition drugs that are intended for the corresponding age category should be used.

Use in Pregnancy and Lactation

If it is necessary to prescribe a parenteral nutrition drug during pregnancy, the presence of contraindications for use and precautions in the current clinical situation should be taken into account.

The use of parenteral nutrition solutions during lactation (breastfeeding) is not recommended.

Pediatric Use

In children and adolescents under 18 years of age, only those parenteral nutrition drugs that are intended for the corresponding age category should be used.

Special Precautions

Intravenous administration of amino acid solutions is accompanied by increased urinary excretion of trace elements, especially copper and zinc. This must be taken into account when selecting doses of trace elements, especially during long-term therapy.

When administering a parenteral nutrition drug, regular monitoring of water-electrolyte balance and blood acid-base status, blood sugar concentration, and serum ionogram should be performed. During long-term therapy, monitoring of blood parameters (coagulogram, liver function indicators) is necessary.

Due to the risk of pseudoagglutination, it is not recommended to use the same infusion systems for administering blood products and multicomponent amino acid solutions.

Use in pediatrics

During parenteral nutrition of young children, the following indicators must be taken into account: urine nitrogen, ammonia content, glucose, electrolytes, triglycerides (with additional administration of fat emulsions), liver enzymes, serum osmolarity, acid-base balance, and water-salt metabolism. Too rapid infusion can lead to the loss of amino acids through the kidneys and, as a result, to an amino acid imbalance.

In pediatrics, only those parenteral nutrition drugs that are intended for this category of patients should be used.

Drug Interactions

Parenteral nutrition drugs are multicomponent solutions. When adding other solutions or a lipid emulsion to the drug used, the compatibility of all ingredients must be taken into account.

Simultaneous administration of arginine with thiazide diuretics and aminophylline increases the insulin content in the blood.

Estrogens and oral contraceptives can increase the concentration of growth hormone caused by arginine and reduce the glucagon and insulin response to arginine.

With simultaneous use of arginine with spironolactone, the development of severe hyperkalemia is possible.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.