Articaine + Epinephrine (Solution) Instructions for Use
ATC Code
N01BB58 (Articaine in combination with other drugs)
Active Substances
Articaine (Rec.INN registered by WHO)
Epinephrine (Rec.INN registered by WHO)
Clinical-Pharmacological Group
Local anesthetic with a vasoconstrictor component for use in dentistry
Pharmacotherapeutic Group
Local anesthetic agent + alpha- and beta-adrenomimetic
Pharmacological Action
A combined medicinal product that exerts a local anesthetic effect.
Articaine is a local anesthetic of the amide type from the thiophene series. Its mechanism of action is due to the stabilization of neuronal membranes and the prevention of the generation and conduction of nerve impulses.
Epinephrine is an adrenomimetic. It causes vasoconstriction at the injection site, which slows the absorption of articaine and prolongs the duration of the local anesthetic effect.
The onset of action is 0.5-3 minutes, and the duration of action is 45 minutes.
Indications
Infiltration and conduction anesthesia (including in dentistry – tooth extraction, cavity filling, tooth preparation for crowns).
ICD codes
| ICD-10 code | Indication |
| Z51.4 | Preparatory procedures for subsequent treatment or examination, not elsewhere classified |
| ICD-11 code | Indication |
| QB9A | Preparatory procedures for subsequent treatment |
Dosage Regimen
| The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen. |
Solution
Infiltration anesthesia: tonsillectomy (per tonsil) – 5-10 ml; reduction of fractures – 5-20 ml; perineal suture – 5-15 ml.
Conduction anesthesia: Oberst’s anesthesia – 2-4 ml, retrobulbar – 1-2 ml, intercostal – 2-4 ml (per segment), paravertebral – 5-10 ml, peridural (epidural) – 10-30 ml, sacral – 10-30 ml, trigeminal nerve block – 1-5 ml, stellate ganglion block – 5-10 ml, brachial plexus block – 10-30 ml (supraclavicular or axillary approach), external genitalia block – 7-10 ml (per side), paracervical block – 6-10 ml (per side).
For uncomplicated extraction of maxillary teeth in a non-inflammatory stage, inject under the mucous membrane in the area of the transitional fold – vestibular depot 1.7 ml per tooth, if necessary – an additional 1-1.7 ml; palatal incision or suture – palatal depot 0.1 ml.
For extraction of mandibular premolars (5-5) in an uncomplicated stage, infiltration anesthesia provides an effect equivalent to conduction anesthesia.
For cavity preparation and tooth preparation for crowns, except for mandibular molars – vestibular injection of 0.5-1.7 ml per tooth. The maximum dose is 7 mg/kg.
Adverse Reactions
From the central nervous system (dose-dependent): headache, impaired consciousness (up to loss of consciousness); respiratory disorders (up to apnea); tremor, muscle twitching, convulsions.
From the digestive system: nausea, vomiting, diarrhea.
From the sensory organs: rarely – transient visual disturbances (up to blindness), diplopia.
From the cardiovascular system: decreased blood pressure, tachycardia, bradycardia, arrhythmia.
Allergic reactions: skin hyperemia and itching, conjunctivitis, rhinitis, angioedema of varying severity (including edema of the upper and/or lower lip and/or cheeks, laryngeal edema with difficulty swallowing, urticaria, difficulty breathing), anaphylactic shock.
Local reactions: swelling or inflammation at the injection site, appearance of ischemic zones at the injection site (up to the development of tissue necrosis – in case of accidental intravascular injection); nerve damage (up to the development of paralysis) – occurs only due to improper injection technique.
Contraindications
B12-deficiency anemia; methemoglobinemia; paroxysmal ventricular tachycardia; atrial tachyarrhythmia; angle-closure glaucoma; hypoxia; intolerance to sulfite groups (especially in bronchial asthma); hypersensitivity to the components of the combination.
With caution: cholinesterase deficiency, renal failure, bronchial asthma, diabetes mellitus, hyperthyroidism, arterial hypertension, children under 4 years of age (efficacy and safety not established).
For paracervical block: preeclampsia, bleeding in the third trimester of pregnancy, amnionitis.
Use in Pregnancy and Lactation
It does not have a harmful effect on the fetus (except for possible bradycardia) with any technique of application and dosage.
During lactation, there is no need to interrupt breastfeeding, as clinically significant concentrations of articaine are not detected in breast milk.
Use in Renal Impairment
With caution in renal failure.
Pediatric Use
With caution in children under 4 years of age (efficacy and safety not established).
Special Precautions
Do not administer intravenously! To avoid intravascular injection, an aspiration test must be performed. The injection pressure should correspond to the sensitivity of the tissue.
Do not inject into an inflamed area.
Food intake is possible only after sensitivity is restored.
Effect on the ability to drive vehicles and operate machinery
The patient’s eligibility to drive vehicles or engage in activities requiring high mental and motor reactivity is determined by the physician.
Drug Interactions
Tricyclic antidepressants, MAO inhibitors enhance the hypertensive effect.
The local anesthetic effect of articaine is enhanced and prolonged by vasoconstrictors.
Non-selective beta-blockers increase the risk of hypertensive crisis and severe bradycardia.
Storage Conditions
Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.
Dispensing Status
Rx Only
Important Safety Information
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.
Medical DisclaimerBrand (or Active Substance), Marketing Authorisation Holder, Dosage Form
Injection solution 40 mg+5 mcg/1 ml: cartridge 1.8 ml 10 pcs.
Marketing Authorization Holder
Laboratorios Inibsa, S.A. (Spain)
Dosage Form
 |
Articaine Inibsa | Injection solution 40 mg+5 mcg/1 ml: cartridge 1.8 ml 10 pcs. |
Dosage Form, Packaging, and Composition
| Solution for injection | 1 ml |
| Articaine hydrochloride | 40 mg |
| Epinephrine (as bitartrate) | 5 mcg |
1.8 ml – cartridges (10) – blister packs (10) – cardboard boxes.
Injection solution 40 mg+10 mcg/1 ml: cartridge 1.8 ml 10 pcs.
Marketing Authorization Holder
Laboratorios Inibsa, S.A. (Spain)
Dosage Form
|
Articaine Inibsa | Injection solution 40 mg+10 mcg/1 ml: cartridge 1.8 ml 10 pcs. |
Dosage Form, Packaging, and Composition
| Solution for injection | 1 ml |
| Articaine hydrochloride | 40 mg |
| Epinephrine (as bitartrate) | 10 mcg |
1.8 ml – cartridges (10) – blister packs (10) – cardboard boxes.
Solution for injection (10 mg+0.005 mg)/ml: amp. 1 ml, 2 ml, 5 ml, 10 ml or 20 ml; 5, 10, 100 or 250 pcs.
Solution for injection (20 mg+0.005 mg)/ml: amp. 1 ml, 2 ml, 5 ml, 10 ml or 20 ml; 5, 10, 100 or 250 pcs.
Solution for injection (40 mg+0.01 mg)/ml: amp. 1 ml or 2 ml; 5, 10, 100 or 250 pcs.
Solution for injection (40 mg+0.005 mg)/ml: amp. 1 ml or 2 ml; 5, 10, 100 or 250 pcs.
Marketing Authorization Holder
Velpharm, LLC (Russia)
Dosage Forms
|
Articaine + Epinephrine | Solution for injection (10 mg+0.005 mg)/ml: amp. 1 ml, 2 ml, 5 ml, 10 ml or 20 ml; 5, 10, 100 or 250 pcs. |
| Solution for injection (20 mg+0.005 mg)/ml: amp. 1 ml, 2 ml, 5 ml, 10 ml or 20 ml; 5, 10, 100 or 250 pcs. | ||
| Solution for injection (40 mg+0.01 mg)/ml: amp. 1 ml or 2 ml; 5, 10, 100 or 250 pcs. | ||
| Solution for injection (40 mg+0.005 mg)/ml: amp. 1 ml or 2 ml; 5, 10, 100 or 250 pcs. |
Dosage Form, Packaging, and Composition
Solution for injection transparent colorless or with a yellowish tint.
| 1 ml | |
| Articaine hydrochloride | 10 mg |
| Epinephrine bitartrate | 0.009 mg |
| (in terms of Epinephrine) | 0.005 mg |
Excipients: sodium metabisulfite (sodium disulfite), sodium chloride, water for injection.
1 ml – ampoules (5) – blister pack (1) – cardboard boxes.
1 ml – ampoules (5) – blister pack (2) – cardboard boxes.
1 ml – ampoules (5) – blister pack (20) – cardboard container.
1 ml – ampoules (5) – blister pack (50) – cardboard container.
2 ml – ampoules (5) – blister pack (1) – cardboard boxes.
2 ml – ampoules (5) – blister pack (2) – cardboard boxes.
2 ml – ampoules (5) – blister pack (20) – cardboard container.
2 ml – ampoules (5) – blister pack (50) – cardboard container.
5 ml – ampoules (5) – blister pack (1) – cardboard boxes.
5 ml – ampoules (5) – blister pack (2) – cardboard boxes.
5 ml – ampoules (5) – blister pack (20) – cardboard container.
5 ml – ampoules (5) – blister pack (50) – cardboard container.
10 ml – ampoules (5) – blister pack (1) – cardboard boxes.
10 ml – ampoules (5) – blister pack (2) – cardboard boxes.
10 ml – ampoules (5) – blister pack (20) – cardboard container.
10 ml – ampoules (5) – blister pack (50) – cardboard container.
20 ml – ampoules (5) – blister pack (1) – cardboard boxes.
20 ml – ampoules (5) – blister pack (2) – cardboard boxes.
20 ml – ampoules (5) – blister pack (20) – cardboard container.
20 ml – ampoules (5) – blister pack (50) – cardboard container.
Solution for injection transparent colorless or with a yellowish tint.
| 1 ml | |
| Articaine hydrochloride | 20 mg |
| Epinephrine bitartrate | 0.009 mg |
| (in terms of Epinephrine) | 0.005 mg |
Excipients: sodium metabisulfite (sodium disulfite), sodium chloride, water for injection.
1 ml – ampoules (5) – blister pack (1) – cardboard boxes.
1 ml – ampoules (5) – blister pack (2) – cardboard boxes.
1 ml – ampoules (5) – blister pack (20) – cardboard container.
1 ml – ampoules (5) – blister pack (50) – cardboard container.
2 ml – ampoules (5) – blister pack (1) – cardboard boxes.
2 ml – ampoules (5) – blister pack (2) – cardboard boxes.
2 ml – ampoules (5) – blister pack (20) – cardboard container.
2 ml – ampoules (5) – blister pack (50) – cardboard container.
5 ml – ampoules (5) – blister pack (1) – cardboard boxes.
5 ml – ampoules (5) – blister pack (2) – cardboard boxes.
5 ml – ampoules (5) – blister pack (20) – cardboard container.
5 ml – ampoules (5) – blister pack (50) – cardboard container.
10 ml – ampoules (5) – blister pack (1) – cardboard boxes.
10 ml – ampoules (5) – blister pack (2) – cardboard boxes.
10 ml – ampoules (5) – blister pack (20) – cardboard container.
10 ml – ampoules (5) – blister pack (50) – cardboard container.
20 ml – ampoules (5) – blister pack (1) – cardboard boxes.
20 ml – ampoules (5) – blister pack (2) – cardboard boxes.
20 ml – ampoules (5) – blister pack (20) – cardboard container.
20 ml – ampoules (5) – blister pack (50) – cardboard container.
Solution for injection transparent colorless or with a yellowish tint.
| 1 ml | |
| Articaine hydrochloride | 40 mg |
| Epinephrine bitartrate | 0.018 mg |
| (in terms of Epinephrine) | 0.01 mg |
Excipients: sodium metabisulfite (sodium disulfite), sodium chloride, water for injection.
1 ml – ampoules (5) – PVC blister packs (1) – cardboard boxes.
1 ml – ampoules (5) – PVC blister packs (2) – cardboard boxes.
1 ml – ampoules (5) – PVC blister packs (20) – cardboard container.
1 ml – ampoules (5) – PVC blister packs (50) – cardboard container.
2 ml – ampoules (5) – PVC blister packs (1) – cardboard boxes.
2 ml – ampoules (5) – PVC blister packs (2) – cardboard boxes.
2 ml – ampoules (5) – PVC blister packs (20) – cardboard container.
2 ml – ampoules (5) – PVC blister packs (50) – cardboard container.
Solution for injection transparent colorless or with a yellowish tint.
| 1 ml | |
| Articaine hydrochloride | 40 mg |
| Epinephrine bitartrate | 0.009 mg |
| (in terms of Epinephrine) | 0.005 mg |
Excipients: sodium metabisulfite (sodium disulfite), sodium chloride, water for injection.
1 ml – ampoules (5) – PVC blister packs (1) – cardboard boxes.
1 ml – ampoules (5) – PVC blister packs (2) – cardboard boxes.
1 ml – ampoules (5) – PVC blister packs (20) – cardboard container.
1 ml – ampoules (5) – PVC blister packs (50) – cardboard container.
2 ml – ampoules (5) – PVC blister packs (1) – cardboard boxes.
2 ml – ampoules (5) – PVC blister packs (2) – cardboard boxes.
2 ml – ampoules (5) – PVC blister packs (20) – cardboard container.
2 ml – ampoules (5) – PVC blister packs (50) – cardboard container.
Injection solution (10 mg+0.005 mg)/ml
Injection solution (20 mg+0.005 mg)/ml
Injection solution (40 mg+0.01 mg)/ml
Injection solution (40 mg+0.005 mg)/ml
Marketing Authorization Holder
Velpharm, LLC (Russia)
Dosage Forms
|
Articaine + Epinephrine Velpharm | Injection solution (10 mg+0.005 mg)/ml |
| Injection solution (20 mg+0.005 mg)/ml | ||
| Injection solution (40 mg+0.01 mg)/ml | ||
| Injection solution (40 mg+0.005 mg)/ml |
Dosage Form, Packaging, and Composition
Solution for injection
| 1 ml | |
| Articaine hydrochloride | 10 mg |
| Epinephrine bitartrate | 0.009 mg, |
| In terms of epinephrine | 0.005 mg |
1 ml – ampoules (10 pcs.) – cardboard boxes – Prescription only
1 ml – ampoules (100 pcs.) – cardboard container – for hospitals
1 ml – ampoules (250 pcs.) – cardboard container – for hospitals
1 ml – ampoules (5 pcs.) – cardboard boxes – Prescription only
10 ml – ampoules (10 pcs.) – cardboard boxes – Prescription only
10 ml – ampoules (100 pcs.) – cardboard container – for hospitals
10 ml – ampoules (250 pcs.) – cardboard container – for hospitals
10 ml – ampoules (5 pcs.) – cardboard boxes – Prescription only
2 ml – ampoules (10 pcs.) – cardboard boxes – Prescription only
2 ml – ampoules (100 pcs.) – cardboard container – for hospitals
2 ml – ampoules (250 pcs.) – cardboard container – for hospitals
2 ml – ampoules (5 pcs.) – cardboard boxes – Prescription only
20 ml – ampoules (10 pcs.) – cardboard boxes – Prescription only
20 ml – ampoules (100 pcs.) – cardboard container – for hospitals
20 ml – ampoules (250 pcs.) – cardboard container – for hospitals
20 ml – ampoules (5 pcs.) – cardboard boxes – Prescription only
5 ml – ampoules (10 pcs.) – cardboard boxes – Prescription only
5 ml – ampoules (100 pcs.) – cardboard container – for hospitals
5 ml – ampoules (250 pcs.) – cardboard container – for hospitals
5 ml – ampoules (5 pcs.) – cardboard boxes – Prescription only
Solution for injection
| 1 ml | |
| Articaine hydrochloride | 20 mg |
| Epinephrine bitartrate | 0.009 mg, |
| In terms of epinephrine | 0.005 mg |
1 ml – ampoules (10 pcs.) – cardboard packs – By prescription
1 ml – ampoules (100 pcs.) – cardboard container – for hospitals
1 ml – ampoules (250 pcs.) – cardboard container – for hospitals
1 ml – ampoules (5 pcs.) – cardboard packs – By prescription
10 ml – ampoules (10 pcs.) – cardboard packs – By prescription
10 ml – ampoules (100 pcs.) – cardboard container – for hospitals
10 ml – ampoules (250 pcs.) – cardboard container – for hospitals
10 ml – ampoules (5 pcs.) – cardboard packs – By prescription
2 ml – ampoules (10 pcs.) – cardboard packs – By prescription
2 ml – ampoules (100 pcs.) – cardboard container – for hospitals
2 ml – ampoules (250 pcs.) – cardboard container – for hospitals
2 ml – ampoules (5 pcs.) – cardboard packs – By prescription
20 ml – ampoules (10 pcs.) – cardboard packs – By prescription
20 ml – ampoules (100 pcs.) – cardboard container – for hospitals
20 ml – ampoules (250 pcs.) – cardboard container – for hospitals
20 ml – ampoules (5 pcs.) – cardboard packs – By prescription
5 ml – ampoules (10 pcs.) – cardboard packs – By prescription
5 ml – ampoules (100 pcs.) – cardboard container – for hospitals
5 ml – ampoules (250 pcs.) – cardboard container – for hospitals
5 ml – ampoules (5 pcs.) – cardboard packs – By prescription
Solution for injection
| 1 ml | |
| Articaine hydrochloride | 40 mg |
| Epinephrine bitartrate | 0.018 mg, |
| Calculated as epinephrine | 0.01 mg |
1 ml – ampoules (10 pcs.) – cardboard packs – By prescription
1 ml – ampoules (100 pcs.) – cardboard container – for hospitals
1 ml – ampoules (250 pcs.) – cardboard container – for hospitals
1 ml – ampoules (5 pcs.) – cardboard packs – By prescription
2 ml – ampoules (10 pcs.) – cardboard packs – By prescription
2 ml – ampoules (100 pcs.) – cardboard container – for hospitals
2 ml – ampoules (250 pcs.) – cardboard container – for hospitals
2 ml – ampoules (5 pcs.) – cardboard packs – By prescription
Solution for injection
| 1 ml | |
| Articaine hydrochloride | 40 mg |
| Epinephrine bitartrate | 0.009 mg, |
| Calculated as epinephrine | 0.005 mg |
1 ml – ampoules (10 pcs.) – cardboard packs – By prescription
1 ml – ampoules (100 pcs.) – cardboard container – for hospitals
1 ml – ampoules (250 pcs.) – cardboard container – for hospitals
1 ml – ampoules (5 pcs.) – cardboard packs – By prescription
2 ml – ampoules (10 pcs.) – cardboard packs – By prescription
2 ml – ampoules (100 pcs.) – cardboard container – for hospitals
2 ml – ampoules (250 pcs.) – cardboard container – for hospitals
2 ml – ampoules (5 pcs.) – cardboard packs – By prescription
Injection solution 40 mg/ml+0.01 mg/ml: amp. 2 ml 3, 5, 10, 20, 50 or 100 pcs.
Injection solution 40 mg/ml+0.005 mg/ml: amp. 2 ml 3, 5, 10, 20, 50 or 100 pcs.
Marketing Authorization Holder
Mir Chemical and Pharmaceutical Concern, LLC (Russia)
Manufactured By
NPC Eskom, PJSC (Russia)
Dosage Forms
|
Articaine with epinephrine | Injection solution 40 mg/ml+0.01 mg/ml: amp. 2 ml 3, 5, 10, 20, 50 or 100 pcs. |
| Injection solution 40 mg/ml+0.005 mg/ml: amp. 2 ml 3, 5, 10, 20, 50 or 100 pcs. |
Dosage Form, Packaging, and Composition
Solution for injection transparent, colorless or slightly colored.
| 1 ml | |
| Articaine | 40 mg |
| Epinephrine bitartrate calculated as epinephrine | 0.01 mg |
Excipients : sodium chloride – 1.122 mg, sodium disulfite – 0.5 mg, water for injection up to 1 ml.
2 ml – ampoules (3) – contour cell packaging (1) – cardboard packs.
2 ml – ampoules (5) – contour cell packaging (1) – cardboard packs.
2 ml – ampoules (10) – contour cell packaging (1) – cardboard packs.
2 ml – ampoules (5) – contour cell packaging (2) – cardboard packs.
2 ml – ampoules (5) – contour cell packaging (4) – cardboard packs.
2 ml – ampoules (10) – contour cell packaging (2) – cardboard packs.
2 ml – ampoules (5) – contour cell packaging (10) – cardboard packs (for hospitals).
2 ml – ampoules (10) – contour cell packaging (5) – cardboard packs (for hospitals).
2 ml – ampoules (5) – contour cell packaging (20) – cardboard packs (for hospitals).
2 ml – ampoules (10) – contour cell packaging (10) – cardboard packs (for hospitals).
Solution for injection transparent, colorless or slightly colored.
| 1 ml | |
| Articaine hydrochloride | 40 mg |
| Epinephrine bitartrate calculated as epinephrine | 0.005 mg |
Excipients : sodium chloride – 1.122 mg, sodium disulfite 0.5 mg, water for injection up to 1 ml.
2 ml – ampoules (3) – contour cell packaging (1) – cardboard packs.
2 ml – ampoules (5) – contour cell packaging (1) – cardboard packs.
2 ml – ampoules (10) – contour cell packaging (1) – cardboard packs.
2 ml – ampoules (5) – contour cell packaging (2) – cardboard packs.
2 ml – ampoules (5) – contour cell packaging (4) – cardboard packs.
2 ml – ampoules (10) – contour cell packaging (2) – cardboard packs.
2 ml – ampoules (5) – contour cell packaging (10) – cardboard packs (for hospitals).
2 ml – ampoules (10) – contour cell packaging (5) – cardboard packs (for hospitals).
2 ml – ampoules (5) – contour cell packaging (20) – cardboard packs (for hospitals).
2 ml – ampoules (10) – contour cell packaging (10) – cardboard packs (for hospitals).
Solution for injection 10 mg+0.005 mg/1 ml: amp. 1 ml, 2 ml, or 5 ml 5 or 10 pcs.; amp. 10 ml or 20 ml 5 pcs., fl. 10 ml 5 pcs., fl. 20 ml or 40 ml 1 pcs.; cartridges 1.7 ml or 1.8 ml 10, 50, or 100 pcs.
Marketing Authorization Holder
Binergia JSC (Russia)
Manufactured By
Armavir Biopharmaceutical Plant, FSE (Russia)
Dosage Form
|
Articaine-Binergia with epinephrine | Solution for injection 10 mg+0.005 mg/1 ml: amp. 1 ml, 2 ml, or 5 ml 5 or 10 pcs.; amp. 10 ml or 20 ml 5 pcs., fl. 10 ml 5 pcs., fl. 20 ml or 40 ml 1 pcs.; cartridges 1.7 ml or 1.8 ml 10, 50, or 100 pcs. |
Dosage Form, Packaging, and Composition
Solution for injection transparent, colorless or with a yellowish tint.
| 1 ml | |
| Articaine hydrochloride | 10 mg |
| Epinephrine bitartrate (calculated as Epinephrine) | 0.009 mg (0.005 mg), |
| Which corresponds to the epinephrine content in the solution 1:200000 |
Excipients : sodium disulfite – 0.5 mg, sodium chloride – 7 mg, disodium edetate – 0.25 mg, 1M sodium hydroxide solution – to pH 5.0, water for injection – up to 1 ml.
1 ml – ampoules of colorless glass (5) – contour plastic packaging (1) – cardboard packs.
1 ml – ampoules of colorless glass (5) – contour plastic packaging (2) – cardboard packs.
2 ml – ampoules of colorless glass (5) – contour plastic packaging (1) – cardboard packs.
2 ml – ampoules of colorless glass (5) – contour plastic packaging (2) – cardboard packs.
5 ml – ampoules of colorless glass (5) – contour plastic packaging (1) – cardboard packs.
5 ml – ampoules of colorless glass (5) – contour plastic packaging (2) – cardboard packs.
10 ml – ampoules of colorless glass (5) – contour plastic packaging (1) – cardboard packs.
20 ml – ampoules of colorless glass (5) – contour plastic packaging (1) – cardboard packs.
20 ml – ampoules of colorless glass (5) – contour plastic packaging (1) – cardboard boxes.
10 ml – vials of colorless glass (5) – contour plastic packaging (1) – cardboard packs.
20 ml – vials of colorless glass (1) – cardboard packs.
40 ml – vials of colorless glass (1) – cardboard packs.
1.7 ml – cartridges of colorless glass (10) – contour plastic packaging (1) – cardboard packs×.
1.7 ml – cartridges of colorless glass (10) – contour plastic packaging (5) – cardboard packs×.
1.7 ml – cartridges of colorless glass (10) – contour plastic packaging (10) – cardboard packs×.
1.8 ml – cartridges of colorless glass (10) – contour plastic packaging (1) – cardboard packs×.
1.8 ml – cartridges of colorless glass (10) – contour plastic packaging (5) – cardboard packs×.
1.8 ml – cartridges of colorless glass (10) – contour plastic packaging (10) – cardboard packs×.
× two protective labels with the company logo (first opening control) are affixed to the pack.
Injection solution (40 mg+0.01 mg)/ml
Marketing Authorization Holder
Binergia JSC (Russia)
Manufactured By
Armavir Biopharmaceutical Plant, FSE (Russia)
Dosage Form
|
Articaine-Binergia with epinephrine forte | Injection solution (40 mg+0.01 mg)/ml |
Dosage Form, Packaging, and Composition
Solution for injection transparent, colorless or with a yellowish tint.
| 1 ml | |
| Articaine hydrochloride | 40 mg |
| Epinephrine bitartrate (calculated as epinephrine) | 0.018 mg (0.01 mg), |
| Which corresponds to the epinephrine content in the solution 1:100000 |
1.7 ml – cartridges (10 pcs.) – cardboard packs – By prescription
1.7 ml – cartridges (100 pcs.) – cardboard packs – By prescription
1.7 ml – cartridges (200 pcs.) – cardboard boxes – for hospitals
1.7 ml – cartridges (250 pcs.) – cardboard boxes – for hospitals
1.7 ml – cartridges (50 pcs.) – cardboard packs – By prescription
1.8 ml – cartridges (10 pcs.) – cardboard packs – By prescription
1.8 ml – cartridges (100 pcs.) – cardboard packs – By prescription
1.8 ml – cartridges (200 pcs.) – cardboard boxes – for hospitals
1.8 ml – cartridges (250 pcs.) – cardboard boxes – for hospitals
1.8 ml – cartridges (50 pcs.) – cardboard packs – By prescription
2 ml – ampoules (10 pcs.) – cardboard packs – By prescription
2 ml – ampoules (100 pcs.) – cardboard boxes – for hospitals
2 ml – ampoules (250 pcs.) – cardboard boxes – for hospitals
2 ml – ampoules (5 pcs.) – cardboard packs – By prescription
Excipients : sodium disulfite – 0.5 mg, sodium chloride – 7 mg, disodium edetate – 0.25 mg, 1M sodium hydroxide solution – to pH 5.0, water for injection – up to 1 ml.
![Articaine + Epinephrine [Solution] 1](https://www.medixlife.com/wp-content/uploads/Medixlife_favi_512.png "Articaine + Epinephrine [Solution] 2")