Bepaderil (Ointment) Instructions for Use

Marketing Authorization Holder

Erkapharm, JSC (Russia)

Manufactured By

Tula Pharmaceutical Factory, LLC (Russia)

ATC Code

D03AX03 (Dexpanthenol)

Active Substance

Dexpanthenol (Rec.INN registered by WHO)

Dosage Form

Bepaderil

Ointment for external use 5%: tubes 30 g or 100 g

Dosage Form, Packaging, and Composition

Ointment for external use 5% is homogeneous, ranging from white with a yellowish tint to light yellow in color, with a specific odor.

Excipients: petrolatum – 27 g, liquid paraffin – 10 g, lanolin – 17 g, cholesterol – 0.5 g, isopropyl myristate – 3 g, methylparahydroxybenzoate (nipagin, methylparaben) – 0.07 g, propylparahydroxybenzoate (nipasol, propylparaben) – 0.03 g, purified water – 37.40 g.

30 g – aluminum tubes (1) – cardboard packs.
100 g – aluminum tubes (1) – cardboard packs.

Clinical-Pharmacological Group

A drug improving trophism and tissue regeneration, for external use

Pharmacotherapeutic Group

Drugs for the treatment of wounds and ulcers; drugs promoting normal scarring; other drugs promoting normal scarring

Pharmacological Action

A tissue regeneration stimulator, it belongs to the B vitamins. Dexpanthenol is a precursor of pantothenic acid.

In the body, it is converted into pantothenic acid, which is a constituent part of coenzyme A and is involved in acetylation processes, carbohydrate and fat metabolism, and in the synthesis of acetylcholine, corticosteroids, and porphyrins.

It stimulates the regeneration of the skin and mucous membranes, normalizes cellular metabolism, accelerates mitosis, and increases the strength of collagen fibers.

It has regenerating, metabolic, and weak anti-inflammatory effects.

Data obtained from animal experiments indicate an increase in fibroblast proliferation and the presence of a regenerating effect.

When applied externally and topically, Dexpanthenol is able to compensate for the increased demand of damaged skin or mucous membranes for pantothenic acid.

Pharmacokinetics

Dexpanthenol is quickly absorbed by the skin and converted into pantothenic acid.

It binds to blood plasma proteins (mainly to albumin and β-globulin).

Pantothenic acid is not metabolized in the body and is excreted unchanged.

Indications

Violation of the integrity of the skin: healing of burns (including sunburns), minor skin injuries (including abrasions, cuts, cracks); prevention and treatment of dry skin, including as a consequence of dermatitis of various origins; daily care of skin areas most exposed to external factors (face, hands); care of the mammary glands during lactation (cracks and redness of the nipples of the mammary gland); care for infants and babies (diaper rash, diaper dermatitis).

ICD codes

Dosage Regimen

Apply the ointment externally to the affected skin areas or for preventive care.

Gently rub in until completely absorbed.

For minor skin injuries such as abrasions, cuts, and cracks, apply a thin layer 1 to 2 times daily.

For the treatment of sunburns and thermal burns, apply as needed to soothe and promote healing.

To prevent and treat dry skin, use daily on areas exposed to external factors like the face and hands.

For diaper dermatitis and diaper rash in infants, apply with each diaper change to clean, dry skin.

During lactation, apply to cracked or reddened nipples after each feeding.

The frequency of application depends on the severity of the condition and the indication for use.

Avoid contact with eyes and mucous membranes.

If no improvement is seen after one week of use, or if symptoms worsen, consult a physician.

Adverse Reactions

In very rare cases, allergic reactions are possible.

Contraindications

Hypersensitivity to dexpanthenol.

Use in Pregnancy and Lactation

Can be used during pregnancy and breastfeeding.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.