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Chlorophyllipt® (Tablets, Solution) Instructions for Use

ATC Code

D06BX (Other chemotherapeutic preparations for topical use)

Active Substance

Eucalypti folium (DAB German Pharmacopoeia)

Clinical-Pharmacological Group

Herbal preparation with antimicrobial action

Pharmacotherapeutic Group

Antimicrobial agent of plant origin

Pharmacological Action

A preparation of plant origin. Aqueous and alcoholic extracts from eucalyptus leaves exhibit bactericidal, antiviral, fungicidal, antiprotozoal, and anti-inflammatory effects. The degree of their severity depends on the content of essential oil (0.3-4.5%).

The activity of the main component of the essential oil, cineole (65-85%), is potentiated by pinenes, myrtenol, and tannins (up to 6%). When taken orally and in inhalations, eucalyptus preparations cause expectorant, mucolytic, and bronchodilator effects, and when applied to the skin – astringent, anti-exudative, antipruritic, anesthetic, and in higher concentrations, local irritant action. The infusion of eucalyptus leaves, due to the essential oil and a small amount of bitters, increases the secretion of the digestive glands and improves digestion. When used in the form of a tincture, a sedative effect is manifested, due to the aldehyde of isovaleric acid.

Chlorophyllipt®, containing a mixture of chlorophylls from eucalyptus leaves, possesses antimicrobial, particularly antistaphylococcal, activity and stimulates regeneration processes. The components of the essential oil, together with organic acids, tannins, and trace elements manganese, zinc, and selenium, increase tissue resistance to hypoxia of various origins.

Indications

As part of combination therapy for acute and chronic infectious and inflammatory diseases of various localization: rhinitis, stomatitis, gingivitis, laryngitis, bronchitis, pneumonia, hyposecretory gastritis, enterocolitis, dysbacteriosis, cholecystitis, pyelonephritis, vaginitis, colpitis, cervical erosion, burns, dermatitis, radiculitis, neuritis, myositis, trophic ulcers, neurosis, mild form of insomnia, osteochondrosis.

ICD codes

ICD-10 code Indication
F48.0 Neurasthenia
F51.0 Nonorganic insomnia
J00 Acute nasopharyngitis (common cold)
J02 Acute pharyngitis
J03 Acute tonsillitis
J04 Acute laryngitis and tracheitis
J15 Bacterial pneumonia, not elsewhere classified
J20 Acute bronchitis
J31.0 Chronic rhinitis (including ozaena, atrophic and hypertrophic rhinitis)
J31.2 Chronic pharyngitis
J35.0 Chronic tonsillitis
J37 Chronic laryngitis and laryngotracheitis
J42 Unspecified chronic bronchitis
K05 Gingivitis and periodontal diseases
K12 Stomatitis and related lesions
K29 Gastritis and duodenitis
K52.9 Noninfective gastroenteritis and colitis, unspecified
K63.8 Other specified diseases of intestine
K81.0 Acute cholecystitis
K81.1 Chronic cholecystitis
L30.9 Dermatitis, unspecified
L98.4 Chronic skin ulcer, not elsewhere classified
M42 Spinal osteochondrosis
M54.1 Radiculopathy
M54.3 Sciatica
M54.4 Lumbago with sciatica
M60 Myositis
M79.2 Neuralgia and neuritis, unspecified
N10 Acute tubulointerstitial nephritis (acute pyelonephritis)
N11 Chronic tubulointerstitial nephritis (chronic pyelonephritis)
N76 Other inflammatory diseases of vagina and vulva
N86 Erosion and ectropion of cervix
T30 Burns and corrosions of unspecified body region
ICD-11 code Indication
6A8Z Affective disorders, unspecified
7A00 Chronic insomnia
7A01 Acute insomnia
7A0Z Insomnia disorders, unspecified
8B93.Z Radiculopathy, unspecified
8E4A.1 Paraneoplastic or autoimmune diseases of the peripheral or autonomic nervous system
CA00 Acute nasopharyngitis
CA02.Z Acute pharyngitis, unspecified
CA03.Z Acute tonsillitis, unspecified
CA05 Acute laryngitis or tracheitis
CA09.0 Chronic rhinitis
CA09.2 Chronic pharyngitis
CA0F.Y Other specified chronic diseases of the palatine tonsils and adenoids
CA0G Chronic laryngitis or laryngotracheitis
CA20.1Z Chronic bronchitis, unspecified
CA40.0Z Bacterial pneumonia, unspecified
CA42.Z Acute bronchitis, unspecified
DA01.Z Diseases of the oral mucosa, unspecified
DA0B.Z Gingival diseases, unspecified
DA0C.Z Periodontal diseases, unspecified
DA0Z Diseases or disorders of the orofacial complex, unspecified
DA42.Z Gastritis, unspecified
DA51.Z Duodenitis, unspecified
DA7Z Diseases of stomach or duodenum, unspecified
DA90.0 Syndromic diarrhea
DA92.1 Pneumatosis intestinalis of the small intestine
DA98.Z Polyps of small intestine, unspecified
DB31.1 Pneumatosis of the colon
DB36.Z Certain infections of the colon, unspecified
DC12.0Z Acute cholecystitis, unspecified
DC12.1 Chronic cholecystitis
DE2Z Diseases of the digestive system, unspecified
EA40 Tropical phagedenic ulcer
EA85.2Z Hand dermatitis, unspecified
EA85.3 Foot dermatitis
EA89 Generalized eczematous dermatitis of unspecified type
EA8Z Dermatitis or eczema, unspecified
EF60 Ischemic ulceration of the skin
EM0Z Unspecified skin disorder
FA85.Z Defects of vertebral end-plates, unspecified
FB30 Infectious myositis
FB32 Other specified disorders of muscle
FB3Z Disorder of muscle, unspecified
FB56 Specified soft tissue diseases, not elsewhere classified
FB56.0 Granuloma of soft tissue due to foreign body, not elsewhere classified
GA00 Vulvitis
GA02.Z Unspecified vaginitis
GA0Z Inflammatory diseases of female genital tract, unspecified
GA15.1 Erosion or ectropion of cervix
GB50 Acute tubulo-interstitial nephritis
GB51 Acute pyelonephritis
GB55.Z Chronic tubulo-interstitial nephritis, unspecified
GB5Z Renal tubulo-interstitial diseases, unspecified
ME60.2 Ulcerative skin lesion of unspecified nature
ME84.20 Lumbago with sciatica
ME84.3 Sciatica
NE11 Burn of unspecified body region

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Administer orally, topically, externally, by inhalation, or via intracavitary routes based on the specific clinical indication and the pharmaceutical form utilized.

For oral administration of tablets, adhere to the specific product information; typically, use one tablet for oromucosal dissolution several times daily.

For gargling, dilute a 1% alcoholic solution: use 5 ml (approximately one teaspoon) in 30 ml of water.

For intracavitary administration, such as vaginal irrigation or cervical treatment, dilute a 1% solution: use 15 ml in one liter of water.

For enemas, dilute a 1% solution: use 20 ml in one liter of water.

For inhalation therapy, dilute a 1% alcoholic solution: use 1 ml per 10 ml of physiological sodium chloride solution.

For external application on wounds, ulcers, or burns, apply a 2% oil-based solution directly to the affected area.

For internal use of the solution, dilute 5 ml (one teaspoon) of a 1% alcoholic solution in 30 ml of water; administer this three times daily.

Adjust the dose, frequency, and treatment duration individually according to the diagnosed condition, severity, and patient age.

Before initiating a full course, mandatorily perform a sensitivity test by administering 25 drops of a 1% alcoholic solution in one tablespoon of water; observe for 6-8 hours for any allergic manifestations.

Adverse Reactions

Possible allergic reactions to the components of the essential oil and chlorophyllipt; when taken orally in high doses – nausea, vomiting, diarrhea, muscle spasms; with frequent and/or prolonged inhalation use – dryness of the mucous membranes of the respiratory tract.

Contraindications

Hypersensitivity to the components of the essential oil and chlorophyllipt; atrophy of the mucous membranes of the upper respiratory tract.

Use in Pregnancy and Lactation

The use of eucalyptus leaf preparations containing ethyl alcohol is contraindicated during pregnancy and breastfeeding.

Pediatric Use

The use of eucalyptus leaf preparations containing ethyl alcohol is contraindicated in children and adolescents under 18 years of age.

Special Precautions

Use with caution in cases of increased secretion of the digestive glands.

Avoid contact of eucalyptus preparations (especially tincture, eucalyptus oil, chlorophyllipt) with the eyes.

Before starting treatment, it is necessary to check the patient’s sensitivity to the plant. For this, the patient is given a tablespoon of infusion, 10 drops of tincture, or 25 drops of a 1% alcoholic solution of chlorophyllipt in 1 tablespoon of water to drink. If no allergic reactions occur within 6-8 hours, a course of treatment can be prescribed. A negative attitude of the patient towards the smell of eucalyptus may indicate intolerance.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Marketing Authorization Holder

Pharmaceutical Balkans, d.o.o. (Serbia)

Dosage Form

Bottle Rx Icon Chlorophyllipt® Alcoholic 1% solution for oral and external use: 100 mL bottle

Dosage Form, Packaging, and Composition

Alcoholic 1% solution for oral and external use 1 ml
Chlorophyllipt thick extract (extract of Eucalyptus globulus leaves with a content of the sum of chlorophylls not less than 10%) 10 mg

100 ml – dark glass bottles (1) – cardboard packs.

Marketing Authorization Holder

Art-Pharm, LLC (Russia)

Manufactured By

Kirov Pharmaceutical Factory, JSC (Russia)

Dosage Form

Bottle OTC Icon Chlorophyllipt® Alcohol solution for oral, topical, and external use 1%: bottle 25 ml or 50 ml

Dosage Form, Packaging, and Composition

Alcoholic solution for oral, topical, and external use dark green in color, with a characteristic odor; during storage, precipitation is allowed, forming a coating on the walls and bottom of the bottle.

1 ml
Chlorophyllipt thick extract (calculated on dry substance)* 10 mg

* chlorophyllipt – a mixture of chlorophylls obtained from eucalyptus leaves.

Excipients : ethanol (ethyl alcohol) 96% – up to 1 ml.

25 ml – dark glass bottles (1) – cardboard packs.
50 ml – dark glass bottles (1) – cardboard packs.

Marketing Authorization Holder

Vifitech, CJSC (Russia)

Dosage Form

Bottle OTC Icon Chlorophyllipt® Oil solution for topical application 2%: bottle 20 ml or 30 ml

Dosage Form, Packaging, and Composition

Oil solution for topical application 2% 100 ml
Extract of Eucalyptus globulus leaves 2 g

20 ml – dark glass bottles (1) – cardboard packs.
30 ml – dark glass bottles (1) – cardboard packs.

Marketing Authorization Holder

Vifitech, CJSC (Russia)

Dosage Form

Bottle OTC Icon Chlorophyllipt® Sublingual tablets 25 mg: 20, 30 or 50 pcs.

Dosage Form, Packaging, and Composition

Sublingual tablets from light green to green in color with lighter and darker inclusions, flat-cylindrical, with a bevel and a score and a characteristic odor.

1 tab.
Chlorophyllipt (thick extract of Eucalyptus globulus leaves) 25 mg

Excipients : sugar (sucrose) – 617 mg, microcrystalline cellulose – 120 mg, citric acid monohydrate – 30 mg, calcium stearate – 8 mg.

10 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.

Marketing Authorization Holder

Vifitech, CJSC (Russia)

Dosage Form

Bottle OTC Icon Chlorophyllipt® Alcohol solution for oral and topical administration 1%: bottle 25 ml, 50 ml, or 100 ml

Dosage Form, Packaging, and Composition

Alcoholic 1% solution for oral and topical administration 1 ml
Chlorophyllipt thick extract (with antibacterial activity at a concentration of 12.5 mcg in 1 ml of medium) 10 mg

25 ml – dark glass bottles (1) – cardboard packs.
50 ml – dark glass bottles (1) – cardboard packs.
100 ml – dark glass bottles (1) – cardboard packs.

Marketing Authorization Holder

Experimental Plant Of The Ssc Ls Of The Ukrmedprom Association, SC (Ukraine)

Dosage Form

Bottle OTC Icon Chlorophyllipt® Oil solution for topical application 2%: bottle 20 ml

Dosage Form, Packaging, and Composition

Oil solution for topical application 2% 20 ml
Chlorophyllipt thick extract (calculated on 100% content of dry substance) 400 mg

20 ml – dark glass bottles (1) – cardboard packs.

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