Collargol (Solution) Instructions for Use

Marketing Authorization Holder

Pharmkhimkomplekt NPC, LLC (Russia)

Manufactured By

Technopark-Center LLC (Russia)

ATC Code

D08AL (Silver compounds)

Active Substance

Silver proteinate (Grouping name)

Dosage Forms

	Collargol	Solution for topical use 1%: 10 ml or 100 ml fl. or dropper bottles
		Solution for topical use 2%: 10 ml or 100 ml fl. or dropper bottles

Dosage Form, Packaging, and Composition

Solution for topical use as a dark brown liquid.

Excipients: purified water – up to 10 ml.

10 ml – bottles – cardboard packs.
10 ml – dropper bottles – cardboard packs.
100 ml – bottles – cardboard packs.
100 ml – dropper bottles – cardboard packs.

Solution for topical use as a dark brown liquid.

Excipients: purified water – up to 10 ml.

10 ml – bottles – cardboard packs.
10 ml – dropper bottles – cardboard packs.
100 ml – bottles – cardboard packs.
100 ml – dropper bottles – cardboard packs.

Pharmacotherapeutic Group

Antiseptic

Pharmacological Action

A silver-based agent (Silver proteinate contains 7.5-8.5% silver). It has an astringent, antiseptic, and anti-inflammatory effect.

It dissociates to form silver ions, which bind to bacterial DNA and prevent their reproduction on mucous membranes under conditions of topical application.

The mechanism of action of silver proteinate is based on the fact that silver ions precipitate proteins and form a protective film on the damaged mucous membrane, which helps to reduce the sensitivity of nerve endings and constrict blood vessels (this leads to a reduction in edema), which in turn causes the inhibition of inflammatory reactions.

Silver ions also suppress the reproduction of various bacteria.

It is active against gram-positive and gram-negative microorganisms: B. cereus, C. albicans, E. coli, P. aeruginosa, S. aureus, A. niger, S. Abony and others.

Indications

Symptomatic therapy of acute nasopharyngitis, sinusitis; acute rhinitis.

ICD codes

Dosage Regimen

Use topically three times daily.

Administer according to an individual scheme determined by a physician, based on patient age and the specific indication.

For rhinitis and nasopharyngitis, instill the solution into the nasal passages.

For sinusitis, use as part of a comprehensive irrigation or instillation regimen.

Adhere strictly to the prescribed concentration (1% or 2%) and volume per application.

Do not exceed the recommended frequency of application.

The duration of therapy is determined by the treating physician based on clinical response.

Discontinue use and consult a physician if severe irritation, burning, or signs of an allergic reaction occur.

Avoid contact with eyes. If contact occurs, rinse thoroughly with water.

Be aware that nasal discharge may be stained gray or blue.

Adverse Reactions

Possible mild irritation of the mucous membrane, burning, itching, allergic reactions (urticaria, atopic dermatitis, angioedema, anaphylactic shock).

Contraindications

Hypersensitivity to silver proteinate; pregnancy, breastfeeding period; atrophic rhinitis; children under 6 months of age.

When using various medicinal products containing Silver proteinate, the age restrictions for use in children over 6 months of age must be strictly observed.

Use in Pregnancy and Lactation

Use is contraindicated during pregnancy and breastfeeding.

Pediatric Use

Use is contraindicated in children under 6 months of age.

When using various medicinal products containing Silver proteinate, the age restrictions for use in children over 6 months of age must be strictly observed.

Special Precautions

Nasal discharge may be stained gray or blue.

Drug Interactions

Salts of zinc, copper, lead, silver, mercury, iron, aluminum form insoluble precipitates with silver proteinate in solution form.

Silver proteinate is inactivated by alkaloid salts, epinephrine.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.