Corylip (Suppositories) Instructions for Use

Marketing Authorization Holder

Altpharm LLC (Russia)

Contact Information

Altpharm LLC (Russia)

ATC Code

A11JC (Vitamins in combination with other drugs)

Active Substances

Riboflavin (Rec.INN registered by WHO)

Thioctic acid (BAN adopted for use in the United Kingdom)

Cocarboxylase (Rec.INN registered by WHO)

Dosage Form

Corylip

Rectal suppositories 25 mg+2 mg+12 mg: 10 pcs.

Dosage Form, Packaging, and Composition

Rectal suppositories of yellow color, torpedo-shaped, with possible inclusions of orange-yellow color.

Excipients: hard fat (Witepsol H15, Witepsol W35, Kernosol 35, Hard fat produced by “Bunge Loders Croklaan B.V.”, Netherlands) – up to a mass of 0.95 g.

5 pcs. – contour cell packs (2) – cardboard packs.

Clinical-Pharmacological Group

Drug with general tonic action

Pharmacotherapeutic Group

Vitamins; other combined vitamin preparations; combinations of vitamins

Pharmacological Action

A drug with a general tonic action. A combined drug, the action of which is determined by the effects of the vitamins and coenzymes included in its composition, as well as by the synergy of action.

Cocarboxylase hydrochloride (a coenzyme) catalyzes the carboxylation and decarboxylation of α-keto acids, participates in carbohydrate metabolism processes, and indirectly contributes to the synthesis of nucleic acids, proteins, and lipids through participation in the pentose cycle. It activates tissue metabolism. The drug is used for correction in metabolic acidosis, cellular hypoxia, other metabolic disorders, in cases of liver, kidney, cardiovascular system insufficiency, and chronic intoxications.

Riboflavin (vitamin B₂) as a coenzyme of flavoproteins participates in the regulation of redox reactions, as well as in the processes of carbohydrate, protein, and fat metabolism; it plays an important role in hemoglobin synthesis and in maintaining normal visual function of the eye, and the condition of mucous membranes and skin.

Thioctic acid participates in the oxidative decarboxylation of pyruvic acid and α-keto acids, in the regulation of lipid and carbohydrate metabolism, and plays an important role in the body’s energy production process. Thioctic acid has a hepatoprotective effect, improves the detoxification function of the liver, and protects against the effects of exo- and endotoxins.

Corylip improves tissue metabolism in various physiological and pathological conditions requiring correction with co-factors and substrates.

Pharmacokinetics

Data on the pharmacokinetics of the drug Corylip are not provided.

Indications

As monotherapy or as an addition to basic therapy for various pathological conditions in children, incl.

• Chronic tissue hypoxia;
• Reduced immunity;
• Bacterial and viral infections;
• Chronic somatic diseases;
• Chronic intoxications;
• Conditions after severe illnesses;
• Nutritional disorders (hypotrophy).

Periods of intensive growth and establishment of new functions in a child, during intensive physical and mental stress, during stressful situations.

As a general tonic for prevention during the epidemic of infectious diseases.

ICD codes

Dosage Regimen

The drug is used rectally. After removing it from the packaging, the suppository should be inserted into the anus (after preliminary bowel movement).

For newborns and infants, 1/2 suppository/day is prescribed; for children aged 1 to 6 years) – 1 suppository/day; for children aged 6 to 14 years – 1-2 suppositories/day.

The duration of the treatment course is 10 days. The total duration of treatment is 3-4 courses with an interval of 20 days (3-4 months).

Adverse Reactions

Allergic reactions rarely – urticaria, itching, bronchospasm, dyspepsia.

If side reactions occur, the patient should discontinue the drug and consult a doctor.

Contraindications

• Proctitis;
• Rectal bleeding;
• Hypersensitivity to the components of the drug.

Pediatric Use

The drug is intended for use in children.

Special Precautions

Criteria for the duration of treatment, along with the clinical condition, are cytochemical indicators of the activity of peripheral blood leukocyte enzymes (succinate dehydrogenase and glycerophosphate dehydrogenase).

Overdose

Data on overdose of the drug Corylip are not provided.

Drug Interactions

No negative interaction has been noted.

The drug can be used in complex therapy.

Storage Conditions

The drug should be stored out of the reach of children at a temperature not exceeding 9°C (48.2°F).

Shelf Life

The shelf life is 2 years.

Dispensing Status

The drug is dispensed by prescription.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.