CPhG (Solvent) Instructions for Use

Instructions
Dosage forms

ATC Code

V07AC (Auxiliary agents for blood transfusion)

Clinical-Pharmacological Group

Donor blood preservative preparation

Pharmacotherapeutic Group

Hemopreservative-auxiliary substance

Pharmacological Action

Hemopreservative. It provides an anticoagulant effect by binding calcium cations with citrate anions.

Furthermore, dextrose serves as nutrition for blood cells, and phosphate supports the blood buffer system.

Indications

Preservation of donor blood.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
Z51.4	Preparatory procedures for subsequent treatment or examination, not elsewhere classified

ICD-11 code	Indication
QB9A	Preparatory procedures for subsequent treatment

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Collect blood strictly in accordance with the official “Instructions for the Collection of Preserved Donor Blood”.

Use a single container for the collection of one donor blood unit. The resulting preserved blood has a maximum shelf life of 21 days.

Before initiating the procedure, perform a visual inspection of the container to verify the integrity of the consumer packaging and the absence of leaks.

Adverse Reactions

Monitor for signs of allergic reactions in the recipient following transfusion of blood preserved with this solution.

Such reactions are infrequent but may include urticaria, pruritus, or more severe hypersensitivity responses.

Drug Interactions

Consider potential interactions with medications administered to the blood donor prior to collection or added to the blood unit during processing.

The citrate anticoagulant may potentiate the effects of other calcium-binding agents. Exercise caution when transfusing large volumes of citrate-preserved blood to patients receiving medications that affect calcium homeostasis.

Contraindications

Hypersensitivity to any component of the solution, including citrate, dextrose, or phosphate compounds.

Overdose

Overdose is not applicable from direct use of the preservative solution. The primary risk arises from massive transfusion of blood preserved with citrate.

Monitor for citrate toxicity manifested as hypocalcemia (e.g., paresthesia, muscle twitching, ECG changes) and manage with intravenous calcium supplementation as required.

Special Precautions

Intended for blood transfusion departments and stations only.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

CPhG [Rezerv-M, LLC (Russia)]
Solution for hemopreservative 63 ml: bags

Marketing Authorization Holder

Rezerv-M, LLC (Russia)

Dosage Form

CPhG

Solution for hemopreservative 63 ml: bags

Dosage Form, Packaging, and Composition

Hemopreservative solution transparent, slightly yellowish or colorless.

	1 L
Sodium citrate pentasesquihydrate	31.94 g
Dextrose monohydrate	25.5 g
Sodium phosphate monobasic dihydrate	2.51 g
Citric acid monohydrate	3.27 g

Excipients : water for injections up to 1 L.

63 ml – polymer containers for blood and its components with a volume of 500 ml (1) – polypropylene bags.

CPhG [Sintez PJSC (Russia)]
Solution for hemopreservative 43 ml or 63 ml: bags

Marketing Authorization Holder

Sintez PJSC (Russia)

Dosage Form

CPhG

Solution for hemopreservative 43 ml or 63 ml: bags

Dosage Form, Packaging, and Composition

Hemopreservative solution transparent, slightly yellowish or colorless.

	1 L
Sodium citrate pentasesquihydrate	31.94 g
Dextrose monohydrate	25.5 g
Sodium phosphate monobasic dihydrate	2.51 g
Citric acid monohydrate	3.27 g

Excipients : water for injections up to 1 L.

63 ml – polymer containers for blood and its components with a volume of 500 ml (1) – polypropylene bags.
43 ml – polymer containers for blood and its components with a volume of 375 ml (1) – polypropylene bags.

CPhG [Medpolymer Firm, JSC (Russia)]
Solution for hemopreservative: 63 ml container