Depanthenol (Ointment) Instructions for Use

Marketing Authorization Holder

Hemofarm Koncern A.D. (Yugoslavia)

ATC Code

D03AX03 (Dexpanthenol)

Active Substance

Dexpanthenol (Rec.INN registered by WHO)

Dosage Form

Depanthenol

Ointment for external use 5%: tube 30 g

Dosage Form, Packaging, and Composition

Ointment for external use 5% homogeneous, white to pale yellow in color.

30 g – aluminum tubes (1) – cardboard packs.

Clinical-Pharmacological Group

A drug improving trophism and tissue regeneration, for external use

Pharmacotherapeutic Group

Tissue regeneration stimulant

Pharmacological Action

Tissue regeneration stimulator, belongs to the B vitamins. Dexpanthenol is a precursor of pantothenic acid.

In the body, it is converted into pantothenic acid, which is a component of coenzyme A and is involved in acetylation processes, carbohydrate and fat metabolism, and in the synthesis of acetylcholine, corticosteroids, and porphyrins; it stimulates the regeneration of the skin and mucous membranes, normalizes cellular metabolism, accelerates mitosis, and increases the strength of collagen fibers.

It has a regenerative, metabolic, and mild anti-inflammatory effect.

Data obtained from animal experiments indicate an increase in fibroblast proliferation and the presence of a regenerative effect.

When applied externally and locally, Dexpanthenol is able to compensate for the increased demand of damaged skin or mucous membranes for pantothenic acid.

Pharmacokinetics

Dexpanthenol is quickly absorbed through the skin and converted into pantothenic acid.

It binds to blood plasma proteins (mainly to albumin and β-globulin).

Pantothenic acid is not metabolized in the body and is excreted unchanged.

Indications

Violation of the integrity of the skin: healing of burns (including sunburns), minor skin injuries (including abrasions, cuts, cracks); prevention and treatment of dry skin, including as a consequence of dermatitis of various origins; daily care of skin areas most exposed to external factors (face, hands); care of the mammary glands during lactation (cracks and redness of the nipples of the mammary gland); care for infants and babies (diaper rash, diaper dermatitis).

ICD codes

Dosage Regimen

Apply the ointment externally to the affected skin areas.

Use a thin layer and gently rub in until absorbed.

For minor wounds, abrasions, cuts, and cracks: apply 2-3 times daily.

For superficial burns, including sunburn: apply 1-2 times daily.

For treatment and prevention of dry skin: apply as needed, typically 1-2 times daily.

For daily skin care of exposed areas like hands and face: apply once daily.

For diaper rash and diaper dermatitis in infants: apply at each diaper change to clean, dry skin.

For cracked nipples during lactation: apply after each feeding; remove the ointment thoroughly before the next feeding.

The frequency of application depends on the severity of the condition and the indication.

Continue treatment until the skin is fully healed.

Avoid contact with eyes and mucous membranes.

Do not apply to heavily exuding or heavily bleeding wounds.

Adverse Reactions

In very rare cases, allergic reactions are possible.

Contraindications

Hypersensitivity to dexpanthenol.

Use in Pregnancy and Lactation

Can be used during pregnancy and breastfeeding.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.