Dioxysol (Aerosol) Instructions for Use

Marketing Authorization Holder

N.A. Semashko Moscow Chemical Pharmaceutical Preparations, JSC (Russia)

ATC Code

D08AX (Other antiseptics and disinfectants)

Dosage Form

Dioxysol

Topical and external use aerosol 12 mg+60 mg/1 g: 30 g or 60 g cans

Dosage Form, Packaging, and Composition

50 g – dark glass bottles (1) – cardboard packs.

Clinical-Pharmacological Group

Drug with antimicrobial and local anesthetic action for external and topical use

Pharmacotherapeutic Group

Antimicrobial agent + local anesthetic

Pharmacological Action

Dioxysol aerosol exerts antibacterial and local anesthetic action and possesses hyperosmolar activity, due to which it absorbs wound exudate and arrests the inflammatory process in the wound.

The antibacterial action is due to the presence of dioxidine and includes gram-negative and gram-positive, aerobic and anaerobic, spore-forming and asporogenic microflora, as well as hospital strains of bacteria with polyresistance to other chemotherapeutic drugs.

The drug does not exert general toxic, locally irritating, or sensitizing action, and does not damage granulation tissue or skin grafts.

Indications

Dioxysol aerosol is used in the first phase of the wound process:

• In surgery for the treatment of purulent wounds of various localization and genesis, abdominal abscesses after their drainage, intestinal and ligature fistulas, trophic ulcers and bedsores;
• In traumatology for the prevention and treatment of soft tissue suppuration and osteomyelitis;
• In proctology for the prevention and treatment of purulent complications after hemorrhoidectomy, paraproctitis and coccygeal cysts, as well as during reconstructive and restorative operations on the large intestine;
• In combustiology for the prevention of burn wound suppuration and the treatment of infected II-IV degree burns, for the preparation of burn wounds for autodermoplasty, and after plastic surgeries to improve the engraftment of skin grafts;
• In military field surgery for first aid to victims with open soft tissue injuries to prevent their suppuration when primary surgical treatment is impossible.

ICD codes

Dosage Regimen

The aerosol is applied topically to the affected area.

The amount of the drug required for a single application depends on the area of the wound surface. The wound must be completely covered with foam.

The daily dose of Dioxysol aerosol for topical use should not exceed 108 g, and for introduction into the abscess cavity – 70 g.

The course of treatment depends on the course of the wound process and should not exceed 15 days.

Before use, the aerosol can is shaken several times and turned upside down.

The protective cap is removed, the nozzle is placed on the valve stem, the end of which is brought to the affected area and the nozzle head is pressed smoothly.

When pressed all the way down for 1-2 seconds, 13-26 ml (1-2 g) of foam is released from the can, containing 0.01-0.02 g of hydroxymethylquinoxalindioxide.

When treating burns and wounds, the wound surface is cleaned of exudate and necrotic tissues.

The foam is applied in an even layer about 1 cm thick and a sterile gauze bandage is applied.

Dressings are changed once a day when treating wounds and once every 1-2 days when treating burns.

With the bandage-free treatment method, using the nozzle, the foam is introduced into fistulas, wound cavities and pockets, followed by the application of a sterile gauze bandage 1-2 times a day.

After each use, the nozzle must be rinsed with boiled water or boiled for 15 minutes.

Adverse Reactions

When applied to a burn surface, a short-term burning sensation is possible, which usually passes within a few minutes.

Contraindications

• Individual intolerance.

Caution should be exercised when treating pregnant and breastfeeding patients, as well as patients with impaired adrenal function and renal failure.

Dioxysol aerosol is not used for profuse purulent discharge from wounds.

Use in Pregnancy and Lactation

Caution should be exercised when treating pregnant and breastfeeding patients.

Use in Renal Impairment

Caution should be exercised when treating patients with renal failure.

Storage Conditions

In a place protected from light. The can should be protected from falling and impacts.
List B.

Dispensing Status

The drug is dispensed by prescription.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.