Duovit^® Osteo (Tablets) Instructions for Use

Marketing Authorization Holder

Krka, D.D. (Slovenia)

Contact Information

KRKA d.d. (Dietary Supplement) (Russia)

Dosage Form

Duovit® Osteo

Chewable tablets: 40 pcs.

Dosage Form, Packaging, and Product Composition

Composition calcium (carbonate); vitamins: D3, B6, C, K1.

Content per 1 tablet vitamin B6 1 mg, vitamin D3 2.5 mcg, vitamin C 30 mg, calcium 400 mg.

Contains E1400, E300, E1201, E470, E460, E171, E570, E951.

Release form and packaging
Chewable tablets. 40 tablets in a package.

Therapeutic Category

Dietary supplement for strengthening bone tissue and preventing osteoporosis

Scope of Application

Of the Duovit^® Osteo product

Recommended as a dietary supplement – a source of calcium and vitamins C, B6, K, and D.

Indications

Use as an additional source of the specified vitamins and calcium.

• To help compensate for dietary deficiencies of calcium, vitamin D, vitamin K, vitamin C, and vitamin B6.
• To support bone tissue mineralization and help maintain bone density.
• As part of a comprehensive approach for preventing bone mass loss and reducing the risk of osteoporosis development.

ICD codes

Dosage Regimen

Take orally. Chew the tablet thoroughly. Do not swallow whole.

Administer during a meal with food to improve tolerance and absorption.

Adults and children over 14 years of age: take 1 to 2 tablets daily. Adhere strictly to the recommended daily dose.

This is not a medicine. The duration of use is determined individually. Consult a specialist.

Adverse Reactions

Adverse reactions are uncommon and typically mild. Discontinue use if they occur.

Possible reactions include allergic reactions such as skin rash, itching, or urticaria.

Gastrointestinal disturbances like constipation, flatulence, or nausea may occur, particularly at the start of use.

Drug Interactions with Other Medicinal Products and Other Forms of Interaction

Calcium can reduce the absorption of certain medications. Maintain an interval of at least 2-3 hours between taking this supplement and other drugs.

Exercise caution with concomitant use of tetracycline antibiotics, bisphosphonates, levothyroxine, and fluoroquinolones.

Vitamin K may antagonize the effect of warfarin and other vitamin K antagonist anticoagulants. Monitor INR closely in patients on such therapy.

Contraindications for Use of the Dietary Supplement

Do not use under the following conditions.

• Hypersensitivity or individual intolerance to any of the components of the dietary supplement, including active substances or excipients.
• Diagnosed phenylketonuria, due to the presence of the sweetener aspartame (E951), which is a source of phenylalanine.
• Severe hypercalcemia or conditions predisposing to it (e.g., hyperparathyroidism, sarcoidosis).
• Severe renal impairment or renal failure.

Overdose Symptoms and Recommended Management Procedures

Symptoms of acute overdose are primarily associated with hypercalcemia and hypercalciuria.

Manifestations may include nausea, vomiting, loss of appetite, constipation, abdominal pain, muscle weakness, and mental confusion. In severe cases, cardiac arrhythmias and renal damage can occur.

Discontinue the supplement immediately. Treatment is symptomatic and supportive. Ensure adequate hydration. In severe cases, seek immediate medical attention.

Dispensing Status

Available to the public through pharmacy chains and specialized stores, departments of the retail network.

Storage Conditions

Store in a dry, light-protected place, out of the reach of children, at a temperature not exceeding 25°C (77°F).

Shelf Life

Shelf life – 2 years.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.