Gattart (Tablets) Instructions for Use

Marketing Authorization Holder

Alkaloid AD Skopje (Republic of North Macedonia)

ATC Code

A02AX (Antacids in combination with other agents)

Active Substances

Calcium carbonate (Ph.Eur. European Pharmacopoeia)

Magnesium carbonate (Ph.Eur. European Pharmacopoeia)

Dosage Form

Gattart

Chewable tablets 680 mg+80 mg: 16, 24 or 48 pcs.

Dosage Form, Packaging, and Composition

Chewable tablets from white to almost white, square, with a biconvex surface, rounded corners, beveled on both sides, with a menthol odor.

Excipients : colloidal silicon dioxide – 13.008 mg, partially pregelatinized corn starch – 60 mg, copovidone – 60 mg, xylitol – 299.079 mg, low-substituted hypromellose LH-11 – 65.005 mg, peppermint flavor SD – 6.504 mg, menthol flavor – 3.902 mg, talc – 13.008 mg, magnesium stearate – 19.494 mg.

8 pcs. – blisters (2) – cardboard packs.
8 pcs. – blisters (3) – cardboard packs.
8 pcs. – blisters (6) – cardboard packs.

Clinical-Pharmacological Group

Antacid drug

Pharmacotherapeutic Group

Antacid agent

Pharmacological Action

Antacid drug. Contains Calcium Carbonate and Magnesium carbonate, which provide rapid and prolonged neutralization of excess hydrochloric acid in gastric juice, thereby exerting a protective effect on the gastric mucosa.

Achievement of the therapeutic effect within 3-5 minutes is due to the good solubility of the tablets and the high calcium content.

Pharmacokinetics

As a result of the interaction of the drug with gastric juice, soluble salts of calcium and magnesium are formed in the stomach. The degree of absorption of calcium and magnesium from these compounds depends on the dose of the drug. Maximum absorption is 10% for calcium and 15-20% for magnesium.

A small amount of absorbed calcium and magnesium is excreted by the kidneys. In the intestine, insoluble compounds are formed from soluble salts, which are excreted in the feces.

Pharmacokinetics in special clinical cases

In case of impaired renal function, the concentration of calcium and magnesium in plasma may increase.

Indications

Symptoms associated with increased acidity of gastric juice and reflux esophagitis: heartburn, sour belching, occasional stomach pain, feeling of fullness or heaviness in the epigastric region, dyspepsia (including those caused by dietary errors, medication use, alcohol abuse, coffee, nicotine); dyspepsia in pregnancy.

ICD codes

Dosage Regimen

The drug is taken orally.

For adults and children over 12 years, chew 1-2 tablets when symptoms appear.

Alternatively, hold the tablets in the mouth until they are completely dissolved.

If symptoms persist, you may repeat the dose after 2 hours.

Do not exceed a maximum daily dose of 11 tablets.

For dyspepsia during pregnancy, use the same regimen.

Take other medications 1-2 hours before or after taking this antacid to avoid interactions.

Do not use in children under 12 years of age.

Patients with impaired renal function should avoid long-term use at high doses.

Adverse Reactions

Allergic reactions very rarely – rash, angioedema, anaphylactic reactions.

When the recommended doses are followed, the drug is well tolerated.

Contraindications

Severe renal failure; hypercalcemia; hypophosphatemia; nephrocalcinosis; children under 12 years of age; sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption syndrome; hypersensitivity to the components of the drug.

Use in Pregnancy and Lactation

When used in recommended doses, the drug does not pose a danger to the fetus or child.

Use in Renal Impairment

Contraindicated in severe renal failure, nephrocalcinosis.

Pediatric Use

Contraindicated in children under 12 years of age.

Special Precautions

When prescribing the drug to patients with impaired renal function, the concentration of magnesium, phosphorus and calcium in the blood serum should be regularly monitored.

Patients with impaired renal function are not recommended to take the drug for a long time in high doses.

Use of the drug in high doses may increase the risk of kidney stones.

Effect on the ability to drive vehicles and mechanisms

The use of the drug does not affect the ability to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug Interactions

A change in the acidity of gastric juice caused by taking antacids may lead to a decrease in the rate and extent of absorption of other drugs taken simultaneously, therefore medications should be taken 1-2 hours before or after taking antacids.

With simultaneous use, antacids reduce the absorption of antibiotics of the tetracycline group, fluoroquinolones, cardiac glycosides, levothyroxine, iron preparations, phosphates, fluorides.

With simultaneous use with thiazide diuretics, the concentration of calcium in the blood serum should be regularly monitored.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.