Gliricum + hypericum (Capsules) Instructions for Use

Marketing Authorization Holder

Artelar, LLC (Russia)

Manufactured By

VTF, LLC (Russia)

Dosage Form

Gliricum + hypericum

Capsules: 30 pcs.

Dosage Form, Packaging, and Product Composition

Capsules weighing 615 mg.

^# according to the “Unified Sanitary, Epidemiological, and Hygienic Requirements for Goods Subject to Sanitary and Epidemiological Surveillance (Control)” (Appendix 5).
Information on the nutritional value of the product is determined by calculation based on the average content of the biologically active substance (BAS) in the product.

Composition Glycine, Griffonia seed extract, gelatin*, hop extract, St. John’s wort extract (natural extract, silicon dioxide), carrier (dextrose (glucose) monohydrate), anti-caking agents (amorphous silicon dioxide, magnesium stearate), colorant (titanium dioxide*).

* components of the gelatin capsule.

15 pcs. – blisters (2) – cardboard packs.

Therapeutic Category

Dietary supplement with sedative action

Indications

• As a dietary supplement to the diet, a source of glycine and flavonoids, to help reduce nervous tension and improve mood.
• For use as a mild sedative to support emotional stability during periods of stress and anxiety.
• To support the function of the central nervous system and promote mental balance.

It is important to understand that this product is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. The effects are supportive and not a substitute for medical treatment for diagnosed psychiatric or neurological conditions.

Contraindications

• Individual intolerance to any of the components of the dietary supplement.
• Pregnancy and breastfeeding (due to the presence of St. John’s wort extract and the lack of sufficient safety data for these populations).
• Concomitant use with antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs), due to the risk of serotonin syndrome.
• Patients with severe liver or kidney disease.
• Children and adolescents under 18 years of age.

Before starting use, it is strongly recommended to consult with a healthcare professional to assess potential risks and ensure the supplement is appropriate for your individual health status.

Dosage Regimen

The recommended dose for adults is 2 capsules per day, taken orally with meals. The capsules should be swallowed whole with a sufficient amount of water (approximately 100-150 ml).

The duration of continuous use should not exceed one month. If it is necessary to repeat the course, a break should be taken, and a second course should only be started after consultation with a doctor. Do not exceed the recommended daily dose.

The timing of administration can be adjusted based on individual response; for some, taking the dose in the evening may be preferable to support restful sleep, while for others, a morning dose may be more suitable for mood support throughout the day.

Adverse Reactions

When used at the recommended dosage, adverse reactions are uncommon. However, in rare cases or in individuals with particular sensitivity, the following may occur: allergic reactions (skin rash, itching, urticaria), dyspeptic symptoms (nausea, discomfort in the epigastric region), headache, or drowsiness.

St. John’s wort extract, one of the active components, is known to cause photosensitivity in some individuals. This means an increased sensitivity to sunlight, which can manifest as a rash or sunburn after minimal sun exposure. It is advisable to limit direct sun exposure and use sunscreen while taking this product.

If any of these or other undesirable effects occur, you should stop taking the supplement and consult a doctor.

Drug Interactions

St. John’s wort extract is a potent inducer of cytochrome P450 enzymes (particularly CYP3A4) and P-glycoprotein. This can lead to a significant decrease in the plasma concentration and therapeutic efficacy of a wide range of concurrently administered medications.

Extreme caution and medical supervision are required when taking this supplement with the following drugs: anticoagulants (e.g., warfarin), anticonvulsants (e.g., carbamazepine, phenobarbital), antidepressants (SSRIs, SNRIs, MAOIs, tricyclics), immunosuppressants (e.g., cyclosporine, tacrolimus), some antiretroviral drugs (e.g., indinavir), digoxin, theophylline, and oral contraceptives (reduced contraceptive effect and risk of breakthrough bleeding).

The combination with other serotonergic agents, including other dietary supplements like tryptophan or SAM-e, increases the risk of developing serotonin syndrome, a potentially life-threatening condition characterized by agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, and loss of muscle coordination.

Overdose

In case of a significant overdose (taking a dose many times higher than recommended), symptoms associated with the potentiation of the product’s effects may occur. These may include severe drowsiness, nausea, vomiting, dizziness, and signs of serotonin syndrome (agitation, tremor, sweating, hyperthermia).

There is no specific antidote. In case of suspected overdose, immediately discontinue the supplement and seek urgent medical attention or contact a poison control center. Treatment is symptomatic and supportive. It is important to inform the medical staff about all the ingredients of the product taken.

To prevent overdose, strictly adhere to the recommended dosage and keep the product out of the reach of children.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.