Glugicir (Solvent) Instructions for Use
ATC Code
V07AC (Auxiliary agents for blood transfusion)
Active Substances
Dextrose (Ph.Eur.)
Sodium citrate (Ph.Eur.)
Clinical-Pharmacological Group
Donor blood preservative preparation
Pharmacotherapeutic Group
Hemopreservative-auxiliary substance
Pharmacological Action
Anticoagulant agent. It binds calcium ions (plasma coagulation factor IV) and prevents hemocoagulation in vitro.
The dextrose contained in the preparation serves as an energy substrate; it participates in metabolism, enhances redox processes, and improves the antitoxic function of the liver.
Indications
Preservation of donor blood.
ICD codes
| ICD-10 code | Indication |
| Z51.4 | Preparatory procedures for subsequent treatment or examination, not elsewhere classified |
| ICD-11 code | Indication |
| QB9A | Preparatory procedures for subsequent treatment |
Dosage Regimen
| The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen. |
Solvent
Blood is collected into “Gemasin” polymer containers, polymer containers for plasmapheresis, or polymer containers for plateletpheresis with a capacity of 250 ml, 375 ml, 500 ml, and 600 ml in a ratio of 1 volume of hemopreservative to 4 volumes of blood.
The collection of blood, the preparation of its components, and further use are carried out in accordance with the Instruction for the Collection and Preservation of Donor Blood approved by the Ministry of Health of the Russian Federation on May 29, 1995 (as amended by the letter of the Ministry of Health of the Russian Federation dated September 8, 1999 N2510/9770-99-32) and the instructions for the use of the products.
1. Before blood collection, perform a visual inspection of the bottle with the solution, paying attention to its integrity, tightness, the appearance of the solution, its transparency, and the expiration date.
If there are cracks in the glass, violations of sealing, closure, cloudiness of the solution, or mechanical impurities (lint, fragments of the cork or glass, etc.), the bottles with the solution must not be used.
2. Blood collection from a donor is performed using a sterile, single-use plastic system for blood collection.
3. On bottles with the preservative solution, sealed with metal caps covering the rubber stopper, bend the metal plate at the notch using a sterile instrument, giving it a vertical position, thereby exposing the central part of the rubber stopper.
The part of the rubber stopper opened in this way is sequentially treated with a swab moistened with alcohol, then with a 5% alcohol solution of iodine, or a 0.5% solution of iodopyrone, or a 0.5% solution of iodonate.
4. Puncture the exposed central part of the stopper with the air vent needle to half its length, then with the second needle connected to the blood collection system, all the way. It is recommended to insert the needles with the bevel facing up at a slight angle to each other and at an angle of 65-70°C (149-158°F) to the stopper.
5. Place the assembled bottles with satellite vials on a stand located below the level of the donor’s elbow bend. The bottle with the preservative solution should be in an inclined position during blood collection to prevent foaming.
6. As the bottle fills, periodically mix the blood with the preservative solution by gentle rocking and circular movements (manually or automatically).
7. If blood enters the bottle drop by drop or stops flowing, immediately find and establish the cause of this (change the position of the needle in the vein, replace the air filter, reposition the tourniquet on the donor’s arm).
When checking the correct application of the tourniquet or changing the air filter, first apply a clamp to the blood collection system. If the blood flow stops due to blockage of the air vent needle by a piece of the rubber stopper, without removing the tourniquet, immediately apply a clamp to the donor tube and replace the obstructed air vent with a new one to avoid air embolism. When checking the patency of the blood collection system, do not violate its tightness.
8. After finishing blood collection, apply a clamp to the system and transfer the needle from the main bottle to the satellite vial, which, after removing the clamp, is filled with blood coming from the donor’s vein. The system is clamped, the needle is removed from the donor’s vein, and a sterile dressing is applied to the venipuncture site. After removing the clamp, the second satellite vial is filled with the blood remaining in the system. Blood from the satellite vials is used for control serological and biochemical tests.
9. After blood collection from the donor, remove the needle with the air filter from the bottle with the collected blood. Treat the puncture site on the stopper with an antiseptic, and return the flap of the metal cap to its original (horizontal) position.
10. It is mandatory, in the presence of the donor, to verify the donor’s last name, first name, and patronymic against the registration card and, after detaching the labels from it, stick them on the bottle with the preserved blood and the satellite vials.
11. The neck of the bottle is paraffined by immersion in molten hot paraffin, covered with clean parchment paper (cellophane or polyethylene film) and tied with twine or a pharmaceutical rubber ring is put on. Instead of paraffin, sealing of blood bottles can be done using Unna’s paste.
12. A blood “passport” is pasted onto the bottle, while the manufacturer’s label is preserved.
13. Packaged and sealed glass bottles with blood and attached satellite vials are placed in special metal nets as soon as possible after collection and transferred for storage to a refrigerator at a temperature of 2-6°C (35.6-42.8°F).
Special Precautions
The shelf life of preserved blood at a temperature of 2-6°C (35.6-42.8°F) is 21 days.
Freezing of the solution during transportation is allowed.
Before use, it is necessary to check the integrity of the consumer packaging and the tightness of the container.
Cloudiness of the polymer container and the presence of moisture in the bag with containers, provided the containers are sealed, is not a contraindication for the use of the preparation.
Storage Conditions
Store at 8°C (46°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.
Dispensing Status
Rx Only
Important Safety Information
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.
Medical DisclaimerBrand (or Active Substance), Marketing Authorisation Holder, Dosage Form
Solution for hemopreservative: 50 ml bottles 24 pcs. or 75 ml bottles 12 pcs.
Marketing Authorization Holder
Biosintez, PJSC (Russia)
Dosage Form
 |
Glugicir | Solution for hemopreservative: 50 ml bottles 24 pcs. or 75 ml bottles 12 pcs. |
Dosage Form, Packaging, and Composition
Hemopreservative solution transparent, colorless or slightly yellowish.
| 1 L | |
| Dextrose (as monohydrate) | 30 g |
| Sodium citrate (disodium hydrogen citrate) | 20 g |
Excipients : water for injections up to 1 L.
50 ml – glass bottles (24) – cardboard boxes (for hospitals).
75 ml – glass bottles (12) – cardboard boxes (for hospitals).
Solution for hemopreservative: 50 ml, 75 ml, 100 ml, 113 ml, or 120 ml containers
Marketing Authorization Holder
Sintez PJSC (Russia)
Dosage Form
|
Glugicir | Solution for hemopreservative: 50 ml, 75 ml, 100 ml, 113 ml, or 120 ml containers |
Dosage Form, Packaging, and Composition
Hemopreservative solution transparent, colorless or slightly yellowish.
| 100 ml | |
| Sodium citrate (disodium hydrogen citrate) sesquihydrate | 2 g |
| Dextrose monohydrate | 3 g |
Excipients : water for injections up to 100 ml.
50 ml – polymer containers (1) “Gemasin” with a capacity of 250 ml – bags – group packaging.
75 ml – polymer containers (1) “Gemasin” with a capacity of 375 ml – bags – group packaging.
100 ml – polymer containers (1) “Gemasin” with a capacity of 500 ml – bags – group packaging.
113 ml – polymer containers (1) “Gemasin” with a capacity of 575 ml – bags – group packaging.
50 ml – two-chamber polymer containers (1) “Gemasin” with a capacity of 250 ml (empty container capacity 200 ml) – bags – group packaging.
75 ml – two-chamber polymer containers (1) “Gemasin” with a capacity of 375 ml (empty container capacity 300 ml) – bags – group packaging.
100 ml – two-chamber polymer containers (1) “Gemasin” with a capacity of 500 ml (empty container capacity 400 ml) – bags – group packaging.
113 ml – two-chamber polymer containers (1) “Gemasin” with a capacity of 575 ml (empty container capacity 400 ml) – bags – group packaging.
120 ml – two-chamber polymer containers (1) “Gemasin” with a capacity of 600 ml (empty container capacity 400 ml) – bags – group packaging.
100 ml – two-chamber polymer containers (1) for plasmapheresis with a capacity of 500 ml (empty container capacity 400 ml) – bags – group packaging.
113 ml – two-chamber polymer containers (1) for plasmapheresis with a capacity of 575 ml (empty container capacity 400 ml) – bags – group packaging.
50 ml – three-chamber polymer containers (1) “Gemasin” with a capacity of 250 ml (2 empty container capacities of 200 ml each) – bags – group packaging.
75 ml – three-chamber polymer containers (1) “Gemasin” with a capacity of 375 ml (2 empty container capacities of 300 ml each) – bags – group packaging.
100 ml – three-chamber polymer containers (1) “Gemasin” with a capacity of 500 ml (2 empty container capacities of 400 ml each) – bags – group packaging.
113 ml – three-chamber polymer containers (1) “Gemasin” with a capacity of 575 ml (2 empty container capacities of 400 ml each) – bags – group packaging.
120 ml – three-chamber polymer containers (1) “Gemasin” with a capacity of 600 ml (2 empty container capacities of 400 ml each) – bags – group packaging.
100 ml – three-chamber containers (1) set of products for cryopreservation of erythrocytes with a container capacity of 750 ml (one empty container capacity of 200 ml and one empty container capacity of 400 ml) – bags – group packaging.
113 ml – three-chamber containers (1) set of products for cryopreservation of erythrocytes with a container capacity of 750 ml (one empty container capacity of 200 ml and one empty container capacity of 400 ml) – bags – group packaging.
100 ml – three-chamber polymer containers (1) “Gemasin” with a capacity of 500 ml (one empty container capacity of 400 ml, another container capacity of 400 ml with 100 ml of “Ernaf” solution) – bags – group packaging.
113 ml – three-chamber polymer containers (1) “Gemasin” with a capacity of 575 ml (one empty container capacity of 400 ml, another container capacity of 400 ml with 100 ml of “Ernaf” solution) – bags – group packaging.
100 ml – three-chamber polymer containers (1) for plasmapheresis with a capacity of 500 ml (2 empty container capacities of 400 ml each) – bags – group packaging.
113 ml – three-chamber polymer containers (1) for plasmapheresis with a capacity of 575 ml (2 empty container capacities of 400 ml each) – bags – group packaging.
120 ml – three-chamber polymer containers (1) for plateletpheresis with a capacity of 600 ml (2 empty container capacities of 400 ml each) – bags – group packaging.
100 ml – four-chamber polymer containers (1) “Gemasin” with a capacity of 500 ml (2 empty container capacities of 400 ml each and one of 100 ml) – bags – group packaging.
113 ml – four-chamber polymer containers (1) “Gemasin” with a capacity of 575 ml (2 empty container capacities of 400 ml each and one of 100 ml) – bags – group packaging.
120 ml – four-chamber polymer containers (1) “Gemasin” with a capacity of 600 ml (2 empty container capacities of 400 ml each and one of 100 ml) – bags – group packaging.
100 ml – four-chamber polymer containers (1) “Gemasin” with a capacity of 500 ml (2 empty container capacities of 400 ml each, third container capacity of 400 ml with 100 ml of “Ernaf” solution) – bags – group packaging.
113 ml – four-chamber polymer containers (1) “Gemasin” with a capacity of 575 ml (2 empty container capacities of 400 ml each, third container capacity of 400 ml with 100 ml of “Ernaf” solution) – bags – group packaging.
100 ml – four-chamber polymer containers (1) for non-apparatus plasmapheresis into two containers of 500 ml (2 empty container capacities of 400 ml each) – bags – group packaging.
113 ml – four-chamber polymer containers (1) for non-apparatus plasmapheresis into two containers of 575 ml (2 empty container capacities of 400 ml each) – bags – group packaging.
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