Histochrom (Solution) Instructions for Use
ATC Codes
C01EB (Other cardiac preparations)
S01 (Ophthalmologicals)
Clinical-Pharmacological Group
Antioxidant drug
Pharmacotherapeutic Group
Antioxidant agent
Pharmacological Action
Histochrom belongs to the group of antioxidant drugs.
The mechanism of action is associated with the ability of histochrom to stabilize cell membranes, interact with reactive oxygen species and free radicals, and exhibit properties of a chelator for metals of variable valence.
Histochrom reduces the amount of lipid peroxidation products.
Indications
For adults as part of combination therapy for the following ophthalmopathologies:
- Dystrophic diseases of the retina and cornea, macular degeneration;
- Primary open-angle glaucoma;
- Diabetic retinopathy of the retina;
- Hemorrhage into the vitreous body, retina, anterior chamber;
- Circulatory disorders in the central artery and vein of the retina.
ICD codes
| ICD-10 code | Indication |
| H18 | Other disorders of cornea |
| H21.0 | Hyphema |
| H34 | Retinal vascular occlusions |
| H35.0 | Background retinopathy and retinal vascular changes |
| H35.3 | Degeneration of macula and posterior pole |
| H35.6 | Retinal hemorrhage |
| H36.0 | Diabetic retinopathy |
| H40.1 | Primary open-angle glaucoma |
| H43.1 | Vitreous hemorrhage |
| ICD-11 code | Indication |
| 9A78.Z | Other diseases of cornea, unspecified |
| 9A80 | Hyphema |
| 9B71.0Z | Diabetic retinopathy, unspecified |
| 9B74.Z | Retinal vascular occlusion, unspecified |
| 9B78.1Z | Background retinopathy and retinal vascular changes, unspecified |
| 9B78.3Z | Degeneration of macula or posterior pole, unspecified |
| 9B78.5 | Retinal hemorrhage |
| 9B83 | Hemophthalmos |
| 9C61.0Z | Primary open-angle glaucoma, unspecified |
Dosage Regimen
| The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen. |
Solution
The drug is administered intravenously over at least 3 minutes.
50-100 mg of the drug (1 or 2 ampoules of 5 ml solution with a concentration of 10 mg/ml) is dissolved in 20 ml of 0.9% sodium chloride solution immediately before administration.
The same dose can be repeated during the day.
The drug can also be administered by intravenous drip: 1 or 2 ampoules (50-100 mg of the drug) are dissolved in 100 ml of 0.9% sodium chloride solution.
Adverse Reactions
Moderate pain at the injection site after the injection, as well as local allergic reactions, are possible.
Contraindications
- Individual hypersensitivity to the components of the drug;
- Children under 18 years of age.
Use in Pregnancy and Lactation
The safety of use during pregnancy and lactation has not been established, therefore the drug is contraindicated during pregnancy and lactation.
Pediatric Use
Contraindicated in children under 18 years of age.
Overdose
Data on drug overdose are not available.
Drug Interactions
It is not allowed to mix Histochrom with drugs containing proteins, calcium salts, or iron during administration.
Storage Conditions
In a place protected from light at a temperature from 8 to 25°C (77°F). Keep out of reach of children.
Shelf Life
The shelf life is 2 years.
Dispensing Status
By prescription.
Important Safety Information
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.
Medical DisclaimerBrand (or Active Substance), Marketing Authorisation Holder, Dosage Form
Solution for intravenous administration 10 mg/ml: 5 ml amp. 5 or 10 pcs.
Marketing Authorization Holder
Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences (Russia)
Dosage Form
 |
Histochrom | Solution for intravenous administration 10 mg/ml: 5 ml amp. 5 or 10 pcs. |
Dosage Form, Packaging, and Composition
Solution for intravenous administration opaque, brown-black.
| 1 ml | |
| Pentahydroxyethylnaphthoquinone | 10 mg |
Excipients: sodium carbonate 4 mg, water for injections up to 1 ml.
5 ml – ampoules of dark glass (5) – cardboard packs.
5 ml – ampoules of dark glass (10) – cardboard packs.
5 ml – ampoules of dark glass (5) – contour cell packs (1) – cardboard packs.
5 ml – ampoules of dark glass (5) – contour cell packs (2) – cardboard packs.
Solution for injection 0.02%: 1 ml amp. 5 or 10 pcs.
Marketing Authorization Holder
Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences (Russia)
Dosage Form
|
Histochrom | Solution for injection 0.02%: 1 ml amp. 5 or 10 pcs. |
Dosage Form, Packaging, and Composition
| Solution for injection 0.02% | 1 ml |
| Pentahydroxyethylnaphthoquinone | 200 mcg |
1 ml – ampoules of dark glass (5) – contour cell packs (1) – cardboard packs.
1 ml – ampoules of dark glass (5) – contour cell packs (2) – cardboard packs.
1 ml – ampoules of dark glass (10) – contour cell packs (1) – cardboard packs.
![Histochrom [Solution] 1](https://www.medixlife.com/wp-content/uploads/Medixlife_favi_512.png "Histochrom [Solution] 2")