Kashnol^® (Syrup) Instructions for Use

Marketing Authorization Holder

Sedate Health Care (P), Ltd. (India)

Manufactured By

Sanjivani Pharmaceutical, Ltd. (India)

ATC Code

R05CB10 (Mucolytic drugs in combination)

Dosage Form

Kashnol®

Syrup: bottle 100 ml or 200 ml with a measuring cup included

Dosage Form, Packaging, and Composition

Syrup is a red liquid with a raspberry odor and a sweet taste.

Excipients: sucrose, citric acid monohydrate, edetate disodium, sodium benzoate, potassium sorbate, propylene glycol, glycerol, sorbitol solution 70%, color Ponceau 4R, raspberry flavor.

100 ml – dark glass bottles (1) with a measuring cup – cardboard packs.
200 ml – dark glass bottles (1) with a measuring cup – cardboard packs.

Clinical-Pharmacological Group

Drug with mucolytic, expectorant and bronchodilatory action

Pharmacotherapeutic Group

Combined expectorant

Pharmacological Action

A combined drug with bronchodilatory, expectorant, and mucolytic action.

Salbutamol is a bronchodilator that stimulates β₂-adrenergic receptors in the bronchi, blood vessels, and myometrium. It prevents or eliminates bronchospasm, reduces resistance in the airways, and increases vital lung capacity. It causes dilation of the coronary arteries and does not reduce blood pressure.

Bromhexine is a mucolytic agent with expectorant and antitussive action. It increases the serous component of bronchial secretion; activates the cilia of the ciliated epithelium, reduces sputum viscosity, increases its volume, and improves discharge.

Guaifenesin is a mucolytic agent that reduces the surface tension of the structures of the bronchopulmonary apparatus; stimulates the secretory cells of the bronchial mucosa that produce neutral polysaccharides, depolymerizes acid mucopolysaccharides, reduces sputum viscosity, activates the bronchial ciliary apparatus, facilitates sputum removal, and promotes the transition from a non-productive cough to a productive one.

Menthol (racementhol, d-,l-menthol) has expectorant and mucolytic action.

Indications

Acute and chronic bronchopulmonary diseases accompanied by difficulty in sputum discharge: COPD (bronchial asthma, obstructive bronchitis, pulmonary emphysema); tracheobronchitis; pneumonia; pneumoconiosis; pulmonary tuberculosis.

ICD codes

Dosage Regimen

Administer orally three times daily.

Use the provided measuring cup for accurate dosing.

For adults and children over 12 years, administer 10 ml per dose.

For children 6 to 12 years, administer 5 ml per dose.

For children 2 to 6 years, administer 2.5 ml per dose.

Do not administer to children under 2 years of age.

Adhere strictly to the prescribed dosing schedule.

Do not exceed the maximum daily dose.

If a dose is missed, administer it as soon as possible.

Do not double the dose to compensate for a missed one.

The duration of treatment is determined by the physician based on clinical response.

Discontinue use if paradoxical bronchospasm occurs and seek immediate medical attention.

Adverse Reactions

From the nervous system: headache, dizziness, increased nervous excitability, sleep disorders, drowsiness, tremor, convulsions.

From the digestive system: nausea, vomiting, diarrhea, exacerbation of gastric and duodenal ulcers, increased activity of hepatic transaminases (very rarely).

From the cardiovascular system: tachycardia, decreased blood pressure, collapse.

From the urinary system: pink coloration of urine.

Allergic reactions: skin rash, urticaria, paradoxical bronchospasm.

Contraindications

Tachyarrhythmia; myocarditis; aortic stenosis; decompensated diabetes mellitus; thyrotoxicosis; glaucoma; hepatic and/or renal failure; gastric and duodenal ulcer (in the acute stage); arterial hypertension; gastric bleeding; pregnancy; lactation period; hypersensitivity to the components of the combination.

With caution

Diabetes mellitus, arterial hypertension, gastric and duodenal ulcer (in history); simultaneous use of antitussives, non-selective beta-adrenergic receptor blockers and MAO inhibitors.

Use in Pregnancy and Lactation

Contraindicated for use during pregnancy and during lactation (breastfeeding).

Use in Hepatic Impairment

Contraindication — hepatic failure.

Use in Renal Impairment

Contraindication — renal failure.

Pediatric Use

Use is possible according to the dosing regimen.

Special Precautions

Guaifenesin colors urine pink.

It is not recommended to take alkaline drinks simultaneously with the drug.

Drug Interactions

Theophylline and other xanthines when used concomitantly increase the likelihood of tachyarrhythmias.

MAO inhibitors and tricyclic antidepressants enhance the effect of salbutamol and may lead to a sharp decrease in blood pressure.

Anticholinergic drugs administered by inhalation may cause an increase in intraocular pressure.

The drug is incompatible with non-selective beta-blockers.

Diuretics and corticosteroids enhance the hypokalemic effect of salbutamol.

Concomitant use with drugs containing codeine and other antitussives makes it difficult to discharge liquefied sputum.

Bromhexine, which is part of the drug, promotes the penetration of antibiotics into the lung tissue.

It is not recommended to use simultaneously with non-selective beta-adrenergic receptor blockers.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.