Konvarelivin^® (Cream) Instructions for Use

Marketing Authorization Holder

Medical Leasing-Consulting, LLC (Russia)

Manufactured By

Dalkhimpharm, JSC (Russia)

ATC Code

M09AX (Other drugs for the treatment of musculoskeletal system diseases)

Active Substance

Glucosamine (Rec.INN registered by WHO)

Dosage Form

Konvarelivin®

Cream for external use 8%: tubes 50 g, 100 g, or 250 g

Dosage Form, Packaging, and Composition

Cream for external use from light yellow to yellow in color, homogeneous, with a faint characteristic odor.

Excipients: purified water, glycerol, butylene glycol, hydroxyethylcellulose, cetyl alcohol, glyceryl monostearate AP40, glyceryl caprylate/caprate, cetyl ethylhexanoate, dimethicone, macrogol 2 stearyl ether, macrogol 20 stearyl ether, dye tartrazine aluminum lake (E102), methylisothiazolinone, methylparaben, menthol oil, dye curcumin, trolamine.

50 g – polyethylene tubes (1) – cardboard packs.
100 g – polyethylene tubes (1) – cardboard packs.
250 g – polyethylene tubes (1) – cardboard packs.

Clinical-Pharmacological Group

Drug with cartilage tissue regeneration improving and anti-inflammatory action for external use

Pharmacotherapeutic Group

Tissue regeneration stimulant

Pharmacological Action

An agent affecting metabolism in cartilage tissue.

It has anti-inflammatory and analgesic effects, replenishes endogenous glucosamine deficiency, stimulates the synthesis of proteoglycans and hyaluronic acid in the synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage.

It promotes sulfur fixation in the process of chondroitin sulfuric acid synthesis, facilitates normal calcium deposition in bone tissue, inhibits the development of degenerative processes in the joints, restores their function, and reduces joint pain.

Pharmacokinetics

The bioavailability of glucosamine after oral administration is 25% due to the first-pass effect through the liver.

The highest concentrations of glucosamine are found in the liver, kidneys, and articular cartilage.

It is excreted mainly unchanged in the urine; partially in the feces.

T_1/2 is 68 hours.

Indications

Adults for the relief of symptoms of mild to moderate osteoarthritis of the knee; scapulohumeral periarthritis.

ICD codes

Dosage Regimen

Apply externally only. Do not administer orally or intramuscularly.

Apply a thin layer of cream to the affected skin area three to four times daily.

Gently massage the cream into the skin until fully absorbed.

Use the minimum amount necessary to cover the treatment area.

Wash hands thoroughly with soap and water after each application.

Avoid contact with eyes, mucous membranes, and open wounds.

Do not apply to damaged or irritated skin.

The standard treatment duration is typically 2 to 6 weeks.

If no symptomatic improvement occurs within 2-3 weeks, discontinue use and consult a physician.

For osteoarthritis of the knee, apply to the front and sides of the affected knee joint.

For scapulohumeral periarthritis, apply to the skin over the affected shoulder joint.

Do not use occlusive dressings unless specifically directed by a physician.

Adverse Reactions

Possible pain in the epigastric region, nausea, flatulence, diarrhea, constipation, allergic reactions.

Contraindications

Hypersensitivity to glucosamine, phenylketonuria (if the drug contains aspartame), severe chronic renal failure, children under 12 years of age, pregnancy, breastfeeding period.

With caution

Bronchial asthma, diabetes mellitus, intolerance to seafood (shrimp, shellfish).

Use in Pregnancy and Lactation

Contraindicated for use during pregnancy and lactation (breastfeeding).

Use in Renal Impairment

Contraindicated for use in severe chronic renal failure.

Pediatric Use

Contraindicated for use in children under 12 years of age.

Special Precautions

When used in patients with impaired glucose tolerance, with severe hepatic and renal insufficiency, medical supervision is necessary.

The risk of allergic reactions increases with seafood intolerance.

Drug Interactions

When used in combination, Glucosamine enhances the absorption of tetracyclines from the gastrointestinal tract and reduces the absorption of penicillins and chloramphenicol.

Glucosamine is compatible with NSAIDs and corticosteroids.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.