Memoplant^® (Tablets) Instructions for Use

Instructions
Dosage forms

ATC Code

N06DX02 (Ginkgo biloba leaves)

Active Substance

Ginkgo biloba (BP British Pharmacopoeia)

Clinical-Pharmacological Group

Herbal preparation improving cerebral and peripheral circulation

Pharmacotherapeutic Group

Angioprotective agent of plant origin

Pharmacological Action

A herbal preparation. Its action is determined by the nature of its influence on metabolic processes in cells, the rheological properties of blood and microcirculation, as well as on the vasomotor reactions of large blood vessels.

It improves cerebral circulation and the supply of oxygen and glucose to the brain.

It has a vasodilating effect and prevents platelet aggregation.

It normalizes metabolic processes and has an antihypoxic effect on tissues.

It prevents lipid peroxidation and the formation of free radicals of cell membranes.

It has a pronounced anti-edematous effect at the level of the brain and in peripheral tissues.

In various pathological conditions, it prevents an increase in the proteolytic activity of serum.

Indications

Use for the symptomatic management of cerebrovascular insufficiency in geriatric patients.

Manage cognitive deficits including disturbances of memory, concentration, and mental performance.
Alleviate associated neuro-sensory symptoms such as dizziness and tinnitus.
Address concomitant conditions including feelings of fear, sleep disorders, and general malaise of vascular origin.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
F07	Personality and behavioral disorders due to disease, damage or dysfunction of the brain
F51.2	Nonorganic disorders of the sleep-wake schedule
I69	Sequelae of cerebrovascular diseases
R42	Dizziness and giddiness

ICD-11 code	Indication
6E68	Secondary emotionally labile personality disorder
6E6Z	Unspecified secondary mental or behavioral syndromes
7B2Z	Sleep-wake cycle disorders, unspecified
8B25.Z	Sequelae of cerebrovascular disease, unspecified
MB48.Z	Dizziness and giddiness, unspecified

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Administer orally. The standard therapeutic dose for adults is 40 mg taken three times daily.

Adhere strictly to this regimen unless otherwise directed by a physician. Swallow the tablet whole with a sufficient amount of liquid, preferably with meals to improve gastrointestinal tolerance.

Adverse Reactions

Monitor for generally mild and infrequent adverse effects. Gastrointestinal disturbances such as dyspepsia are possible.

Be aware of potential headaches and allergic skin reactions, including rash and pruritus. Discontinue use immediately and seek medical attention if signs of a serious allergic reaction occur.

Contraindications

Do not use under the following conditions:

Hypersensitivity to Ginkgo biloba or any excipient.
Pre-existing conditions with increased bleeding risk: reduced blood clotting, hereditary bleeding diatheses.
Active gastrointestinal erosions or ulcers.
Acute medical events: cerebrovascular accident, myocardial infarction.
Significant arterial hypotension.
Pregnancy and lactation.
Children and adolescents under 18 years of age.

Drug Interactions

Exercise extreme caution with concurrent use of drugs affecting hemostasis.

The combination with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., clopidogrel), and NSAIDs (including acetylsalicylic acid) may potentiate the bleeding risk.

Avoid concomitant use with thrombolytic therapy due to a documented increased risk of intracranial hemorrhage.

Overdose

In case of suspected overdose, discontinue use immediately and institute supportive measures.

Based on the pharmacological profile, monitor for severe gastrointestinal complaints and an increased risk of bleeding. There is no specific antidote; treatment should be symptomatic.

Use in Pregnancy and Lactation

Ginkgo biloba is contraindicated for use during pregnancy and during lactation (breastfeeding).

Pediatric Use

Contraindicated in children and adolescents under 18 years of age.

Special Precautions

The use of Ginkgo biloba preparations should be avoided in the presence of risk factors for the development of intracranial hemorrhage.

Storage Conditions

Store at 2°C (36°F) to 30°C (86°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Memoplant^® [Dr. Willmar Schwabe GmbH & Co. KG (Germany)]
Film-coated tablets, 40 mg: 10, 15, 20, 30, 40, 45, 50, 60, 75, or 100 pcs.

Marketing Authorization Holder

Dr. Willmar Schwabe GmbH & Co. KG (Germany)

Dosage Form

Memoplant^®

Film-coated tablets, 40 mg: 10, 15, 20, 30, 40, 45, 50, 60, 75, or 100 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets brownish-yellow in color, smooth, round.

	1 tab.
Dry extract of Ginkgo biloba leaves* (EGb 761^®**) (35-67:1)	40 mg,
Standardized by content
Flavone glycosides	9.6 mg
Terpene lactones	2.4 mg
(1.12-1.36 mg ginkgolides A, B, C and 1.04-1.28 mg bilobalides)

Extraction solvent acetone 60%.

Excipients : lactose monohydrate – 115 mg, colloidal silicon dioxide – 2.5 mg, microcrystalline cellulose – 60 mg, corn starch – 25 mg, croscarmellose sodium – 5 mg, magnesium stearate – 2.5 mg.

Shell composition: hypromellose – 9.25 mg, macrogol 1500 – 4.625 mg, antifoam emulsion SE2 – 0.008 mg***, titanium dioxide (E171) – 0.38 mg, iron hydroxide (E172) – 1.16 mg, talc – 0.576 mg.

10 pcs. – blisters (1) – cardboard packs.
10 pcs. – blisters (2) – cardboard packs.
10 pcs. – blisters (3) – cardboard packs.
10 pcs. – blisters (5) – cardboard packs.
15 pcs. – blisters (1) – cardboard packs.
15 pcs. – blisters (2) – cardboard packs.
15 pcs. – blisters (3) – cardboard packs.
15 pcs. – blisters (5) – cardboard packs.
20 pcs. – blisters (1) – cardboard packs.
20 pcs. – blisters (2) – cardboard packs.
20 pcs. – blisters (3) – cardboard packs.
20 pcs. – blisters (5) – cardboard packs.

* dry extract obtained from Ginkgo biloba L. leaves, family: Ginkgoaceae;
** Ginkgo biloba extract (manufacturer Schwabe Extracta GmbH & Co.KG, Germany or Wallingstown Company Ltd. / Cara Partners, Ireland) EGb 761^® (number assigned to the extract by the manufacturer);
*** Eur.Ph. monographs for individual components of antifoam emulsion SE2.

Memoplant^® [Dr. Willmar Schwabe GmbH & Co. KG (Germany)]
Film-coated tablets, 80 mg: 10, 15, 20, 30, 40, 45, 50, 60, 75, or 100 pcs.

Marketing Authorization Holder

Dr. Willmar Schwabe GmbH & Co. KG (Germany)

Dosage Form

Memoplant^®

Film-coated tablets, 80 mg: 10, 15, 20, 30, 40, 45, 50, 60, 75, or 100 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets brownish-red in color, round, biconvex; the fracture view is from light yellow to brownish-yellow.

	1 tab.
Dry extract of Ginkgo biloba leaves* (EGb 761^®**) (35-67:1)	80 mg,
Standardized by content
Ginkgo flavone glycosides	19.2 mg
Terpene lactones	4.8 mg
(2.24-2.72 mg ginkgolides A, B, C and 2.08-2.56 mg bilobalides)

Extraction solvent acetone 60%.

Excipients : lactose monohydrate – 45.5 mg, colloidal silicon dioxide – 2 mg, microcrystalline cellulose – 109 mg, corn starch – 10 mg, croscarmellose sodium – 10 mg, magnesium stearate – 3.5 mg.

Shell composition hypromellose – 9.25 mg, macrogol 1500 – 4.625 mg, antifoam emulsion SE2 – 0.008 mg***, titanium dioxide (E171) – 0.892 mg, red iron oxide (E172) – 0.503 mg, talc – 0.576 mg, brown iron oxide (E172) – 0.146 mg.

Memoplant^® [Dr. Willmar Schwabe GmbH & Co. KG (Germany)]
Film-coated tablets, 120 mg: 10, 15, 20, 30, 40, 45, 50, 60, 75, or 100 pcs.

Marketing Authorization Holder

Dr. Willmar Schwabe GmbH & Co. KG (Germany)

Dosage Form

Memoplant^®

Film-coated tablets, 120 mg: 10, 15, 20, 30, 40, 45, 50, 60, 75, or 100 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets brownish-red in color, round, biconvex in shape; the fracture view is from light yellow to brownish-yellow.

	1 tab.
Ginkgo biloba leaves dry extract* (EGb 761^®**) (35-67:1)^#	120 mg,
Standardized by content
Ginkgo flavone glycosides	29.4 mg
Terpene lactones	7.2 mg
(3.36-4.08 mg ginkgolides A, B, C and 3.12-3.84 mg bilobalides)

^#Extraction solvent acetone 60%.

Excipients : lactose monohydrate – 68.25 mg, colloidal silicon dioxide – 3 mg, microcrystalline cellulose – 163.5 mg, corn starch – 15 mg, croscarmellose sodium – 15 mg, magnesium stearate – 5.25 mg.

Shell composition hypromellose – 11.5728 mg, macrogol 1500 – 5.7812 mg, antifoam emulsion SE2 – 0.015 mg***, titanium dioxide (E171) – 1.626 mg, red iron oxide (E172) – 1.3 mg, talc – 0.72 mg.

* dry extract obtained from Ginkgo biloba L. leaves, family: Ginkgoaceae.
** Ginkgo biloba extract (manufacturer Schwabe Extracta GmbH & Co.KG, Germany or Wallingstown Company Ltd. / Cara Partners, Ireland) EGb 761^® (number assigned to the extract by the manufacturer).
*** Eur.Ph. monographs for individual components of antifoam emulsion SE2.