Moxonidine (Tablets) Instructions for Use

Instructions
Dosage forms

ATC Code

C02AC05 (Moxonidine)

Active Substance

Moxonidine (Rec.INN registered by WHO)

Clinical-Pharmacological Group

Selective imidazoline receptor agonist. Antihypertensive drug

Pharmacotherapeutic Group

Antihypertensive agents; centrally-acting antiadrenergic agents; imidazoline receptor agonists; moxonidine

Pharmacological Action

Antihypertensive agent. The mechanism of action of moxonidine is primarily associated with its effect on the central regulation of blood pressure. Moxonidine is predominantly an agonist of imidazoline receptors.

By stimulating these receptors on neurons of the solitary tract, Moxonidine, via a system of inhibitory interneurons, contributes to the suppression of the vasomotor center activity and thus to a reduction in descending sympathetic influences on the cardiovascular system. Blood pressure (systolic and diastolic) decreases gradually. Moxonidine differs from other sympatholytic antihypertensive drugs by its lower affinity for α₂-adrenoceptors, which explains the lower likelihood of developing sedative effects and dry mouth.

Moxonidine increases the insulin sensitivity index (compared to placebo) by 21% in patients with obesity, insulin resistance, and moderate arterial hypertension.

Pharmacokinetics

After oral administration, Moxonidine is rapidly and almost completely absorbed in the upper gastrointestinal tract. The absolute bioavailability is approximately 88%. The time to reach C_max is about 1 hour. Food intake does not affect the pharmacokinetics of moxonidine. Plasma protein binding is 7.2%. The main metabolite of moxonidine is dehydrogenated Moxonidine and guanidine derivatives. The pharmacodynamic activity of dehydrogenated moxonidine is about 10% compared to moxonidine.

The T_1/2 of moxonidine and the metabolite is 2.5 and 5 hours, respectively. Within 24 hours, more than 90% of moxonidine is excreted by the kidneys (about 78% unchanged and 13% as dehydrogenated moxonidine; other metabolites in urine do not exceed 8% of the administered dose). Less than 1% of the dose is excreted via the intestines.

Compared to healthy volunteers, no changes in the pharmacokinetics of moxonidine were noted in patients with arterial hypertension.

Clinically insignificant changes in the pharmacokinetic parameters of moxonidine were noted in elderly patients, probably due to a decrease in the intensity of its metabolism and/or a slightly higher bioavailability.

The excretion of moxonidine largely correlates with CrCl. In patients with moderate renal impairment (CrCl 30-60 ml/min), C_ss in plasma and the terminal T_1/2 are approximately 2 and 1.5 times higher, respectively, than in individuals with normal renal function (CrCl greater than 90 ml/min). In patients with severe renal impairment (CrCl less than 30 ml/min), C_ss in plasma and the terminal T_1/2 are 3 times higher than in patients with normal renal function. Administration of moxonidine in multiple doses leads to predictable accumulation in the body in patients with moderate and severe renal impairment. In patients with end-stage renal disease (CrCl less than 10 ml/min) on hemodialysis, C_ss in plasma and the terminal T_1/2 are 6 and 4 times higher, respectively, than in patients with normal renal function. In all groups, the C_max of moxonidine in plasma is 1.5-2 times higher. In patients with impaired renal function, the dose should be adjusted individually. Moxonidine is removed to a minor extent during hemodialysis.

Indications

Arterial hypertension.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
I10	Essential [primary] hypertension

ICD-11 code	Indication
BA00.Z	Essential hypertension, unspecified

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Tablets

Take orally. The initial dose is on average 200 mcg orally once a day. Maximum single dose – 400 mcg. Individual adjustment of the daily dose is necessary depending on therapy tolerance. Maximum daily dose – 600 mcg in 2 divided doses.

For patients with moderate and severe renal impairment, as well as those on hemodialysis, the initial dose is 200 mcg/day. If necessary and well tolerated, the daily dose can be increased to a maximum of 400 mcg.

Adverse Reactions

From the central nervous system: frequent – headache, dizziness (vertigo), drowsiness; infrequent – fainting.

From the cardiovascular system infrequent – pronounced decrease in blood pressure, orthostatic hypotension, bradycardia.

From the digestive system very frequent – dry mouth; frequent – diarrhea, nausea, vomiting, dyspepsia.

From the skin and subcutaneous tissues: frequent – skin rash, itching; infrequent – angioedema.

From the psyche: frequent – insomnia; infrequent – nervousness.

From the hearing organ and labyrinthine disorders: infrequent – ringing in the ears.

From the musculoskeletal system: frequent – back pain; infrequent – neck pain.

General disorders frequent – asthenia; infrequent – peripheral edema.

Contraindications

Severe bradycardia (less than 50 beats/min), sick sinus syndrome, second and third degree AV block, acute and chronic heart failure, lactation period (breastfeeding), children and adolescents under 18 years of age, hypersensitivity to moxonidine.

Use in Pregnancy and Lactation

Adequate and strictly controlled studies on the safety of moxonidine during pregnancy have not been conducted, so it should not be used in this category of patients.

Should not be used during lactation, as Moxonidine is excreted in breast milk. If it is necessary to use moxonidine during lactation, breastfeeding should be discontinued.

During experimental studies in animals, an embryotoxic effect of the drug was established.

Use in Hepatic Impairment

Contraindicated in severe liver dysfunction.

Use in Renal Impairment

Contraindicated in severe renal dysfunction.

Moxonidine should be used with caution in patients with impaired renal function; in such cases, adjustment of the dosage regimen is required, taking into account CrCl values.

During treatment of patients with impaired renal function, careful monitoring of their condition is necessary.

Pediatric Use

Due to the lack of clinical experience, Moxonidine should not be used in children and adolescents under 16 years of age.

Special Precautions

Particular caution should be exercised when using moxonidine in patients with first-degree AV block (risk of bradycardia); severe coronary artery disease and unstable angina (insufficient experience of use); renal failure.

If it is necessary to discontinue concurrently taken beta-blockers and moxonidine, the beta-blockers should be discontinued first and only after a few days – Moxonidine.

Currently, there is no confirmation that discontinuation of moxonidine leads to an increase in blood pressure. However, abrupt discontinuation of moxonidine is not recommended; the dose should be reduced gradually over 2 weeks.

Effect on the ability to drive vehicles and operate machinery

During treatment, patients should exercise caution when engaging in potentially hazardous activities that require concentration and high speed of psychomotor reactions.

Drug Interactions

Concomitant use of moxonidine with other antihypertensive agents leads to an additive effect.

Tricyclic antidepressants may reduce the effectiveness of centrally acting antihypertensive agents, so their use concomitantly with moxonidine is not recommended.

Moxonidine may enhance the effect of tricyclic antidepressants, tranquilizers, ethanol, sedatives, and hypnotics.

Moxonidine is capable of moderately improving impaired cognitive functions in patients receiving lorazepam.

Moxonidine may enhance the sedative effect of benzodiazepine derivatives when co-administered.

Moxonidine is excreted by tubular secretion. Therefore, interaction with other drugs excreted by tubular secretion cannot be excluded.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Moxonidine [Atoll LLC (Russia)]
Film-coated tablets, 0.2 mg: from 7 to 140 pcs.

Marketing Authorization Holder

Atoll LLC (Russia)

Manufactured By

Ozon, LLC (Russia)

Dosage Form

Moxonidine

Film-coated tablets, 0.2 mg: from 7 to 140 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets white or almost white, round, biconvex; on cross-section, two layers are visible – a core of white or almost white color and a film coating.

	1 tab.
Moxonidine	0.2 mg

Excipients : lactose monohydrate (milk sugar) – 92.8 mg, croscarmellose sodium – 4 mg, povidone K25 – 2 mg, magnesium stearate – 1 mg.

Coating composition hypromellose – 1.71 mg, titanium dioxide – 0.84 mg, macrogol-4000 – 0.45 mg.

From 7 to 14 pcs. – contour cell packaging (from 1 to 10 pcs.) – cardboard packs.
From 10 to 100 pcs. – jars (1) – cardboard packs.

Moxonidine [Atoll LLC (Russia)]
Film-coated tablets, 0.4 mg: from 7 to 140 pcs.

Marketing Authorization Holder

Atoll LLC (Russia)

Manufactured By

Ozon, LLC (Russia)

Dosage Form

Moxonidine

Film-coated tablets, 0.4 mg: from 7 to 140 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets white or almost white, round, biconvex; on cross-section, two layers are visible – a core of white or almost white color and a film coating.

	1 tab.
Moxonidine	0.4 mg

Excipients : lactose monohydrate (milk sugar) – 185.6 mg, croscarmellose sodium – 8 mg, povidone K25 – 4 mg, magnesium stearate – 2 mg.

Coating composition hypromellose – 3.42 mg, titanium dioxide – 1.68 mg, macrogol-4000 – 0.9 mg.

From 7 to 14 pcs. – contour cell packaging (from 1 to 10 pcs.) – cardboard packs.
From 10 to 100 pcs. – jars (1) – cardboard packs.

Moxonidine [Belmedpreparaty RUP (Republic of Belarus)]
Film-coated tablets 0.2 mg: 10, 15, 20, 30, 40 or 60 pcs.
Film-coated tablets 0.4 mg: 10, 15, 20, 30, 40 or 60 pcs.

Marketing Authorization Holder

Belmedpreparaty RUP (Republic of Belarus)

Dosage Forms

	Moxonidine	Film-coated tablets 0.2 mg: 10, 15, 20, 30, 40 or 60 pcs.
		Film-coated tablets 0.4 mg: 10, 15, 20, 30, 40 or 60 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets round, biconvex, coated with a white or almost white coating.

	1 tab.
Moxonidine	0.2 mg

Excipients : povidone K-25, crospovidone, magnesium stearate, lactose monohydrate.

Film coating composition Opadry II white: polyvinyl alcohol, macrogol (polyethylene glycol), talc, titanium dioxide (E-171).

10 pcs. – contour cell packaging (1) – cardboard packs (1).
10 pcs. – contour cell packaging (3) – cardboard packs (1).
15 pcs. – contour cell packaging (1) – cardboard packs (1).
15 pcs. – contour cell packaging (2) – cardboard packs (1).
20 pcs. – contour cell packaging (1) – cardboard packs (1).
20 pcs. – contour cell packaging (2) – cardboard packs (1).
20 pcs. – contour cell packaging (3) – cardboard packs (1).

Film-coated tablets round, biconvex, coated with an orange to red-orange coating.

	1 tab.
Moxonidine	0.4 mg

Excipients : povidone K-25, crospovidone, magnesium stearate, lactose monohydrate.

Film coating composition Opadry II orange: polyvinyl alcohol, macrogol (polyethylene glycol), talc, titanium dioxide (E-171), sunset yellow FCF aluminum lake (FD&C Yellow No. 6) (E-110), iron oxide red (E-172).

Moxonidine [Irbit Chemical Pharmaceutical Plant, JSC (Russia)]
Film-coated tablets, 0.2 mg: 10, 20, 30, 50, 60 or 100 pcs.
Film-coated tablets, 0.3 mg: 10, 20, 30, 50, 60 or 100 pcs.

Marketing Authorization Holder

Irbit Chemical Pharmaceutical Plant, JSC (Russia)

Dosage Forms

	Moxonidine	Film-coated tablets, 0.2 mg: 10, 20, 30, 50, 60 or 100 pcs.
		Film-coated tablets, 0.3 mg: 10, 20, 30, 50, 60 or 100 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets pale pink, round, biconvex; on cross-section – white or almost white.

	1 tab.
Moxonidine	0.2 mg

Excipients : lactose monohydrate, crospovidone, magnesium stearate.

Film coating composition hypromellose, macrogol 6000, talc, iron oxide red, titanium dioxide.

10 pcs. – contour cell packaging (1) – cardboard packs.
10 pcs. – contour cell packaging (2) – cardboard packs.
10 pcs. – contour cell packaging (3) – cardboard packs.
10 pcs. – contour cell packaging (5) – cardboard packs.
10 pcs. – contour cell packaging (6) – cardboard packs.
10 pcs. – contour cell packaging (10) – cardboard packs.
10 pcs. – jars (1) – cardboard packs.
20 pcs. – jars (1) – cardboard packs.
30 pcs. – jars (1) – cardboard packs.
60 pcs. – jars (1) – cardboard packs.

Film-coated tablets pink, round, biconvex; on cross-section – white or almost white.

	1 tab.
Moxonidine	0.3 mg

Excipients : lactose monohydrate, crospovidone, magnesium stearate.

Film coating composition hypromellose, macrogol 6000, talc, iron oxide red, titanium dioxide.

Moxonidine [Pharmazashchita SPC, FSUE FMBA of Russia (Russia)]
Film-coated tablets, 200 mcg: 10, 14, 20, 28, 30, 40, 42, 56, 60 or 98 pcs.

Marketing Authorization Holder

Pharmazashchita SPC, FSUE FMBA of Russia (Russia)

Dosage Form

Moxonidine

Film-coated tablets, 200 mcg: 10, 14, 20, 28, 30, 40, 42, 56, 60 or 98 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets almost white, round, biconvex.

	1 tab.
Moxonidine	200 mcg

Excipients : microcrystalline cellulose – 91.8 mg, povidone K25 – 4 mg, colloidal silicon dioxide – 2.5 mg, magnesium stearate – 0.1 mg.

Film coating composition Opadry^® II 85F19250 Clear [macrogol (polyethylene glycol) – 0.21 mg, polyvinyl alcohol – 0.73 mg, polysorbate 80 – 0.04 mg, talc – 0.42 mg] – 1.4 mg.

10 pcs. – contour cell blisters (1) – cardboard packs.
10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.
10 pcs. – contour cell blisters (4) – cardboard packs.
14 pcs. – contour cell blisters (1) – cardboard packs.
14 pcs. – contour cell blisters (2) – cardboard packs.
14 pcs. – contour cell blisters (3) – cardboard packs.
14 pcs. – contour cell blisters (4) – cardboard packs.
14 pcs. – contour cell blisters (5) – cardboard packs.
14 pcs. – contour cell blisters (7) – cardboard packs.

Moxonidine [Pharmazashchita SPC, FSUE FMBA of Russia (Russia)]
Film-coated tablets, 0.4 mg: 7, 10, 14, 20, 21, 28, 30, 35, 40, 42, 49, 50, 56, 60, 70, 84 or 98 pcs.

Marketing Authorization Holder

Pharmazashchita SPC, FSUE FMBA of Russia (Russia)

Dosage Form

Moxonidine

Film-coated tablets, 0.4 mg: 7, 10, 14, 20, 21, 28, 30, 35, 40, 42, 49, 50, 56, 60, 70, 84 or 98 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets almost white, round, biconvex; engraved with “4” on one side.

	1 tab.
Moxonidine (calculated on the dry substance)	0.4 mg

Excipients: microcrystalline cellulose – 91.6 mg, povidone K25 – 4 mg, colloidal silicon dioxide – 2.5 mg, magnesium stearate – 0.1 mg.

Coating composition hypromellose – 1 mg, castor oil – 0.2 mg, magnesium stearate – 0.1 mg.

7 pcs. – contour cell blisters (1) – cardboard packs.
7 pcs. – contour cell blisters (2) – cardboard packs.
7 pcs. – contour cell blisters (3) – cardboard packs.
7 pcs. – contour cell blisters (4) – cardboard packs.
7 pcs. – contour cell blisters (5) – cardboard packs.
7 pcs. – contour cell blisters (6) – cardboard packs.
7 pcs. – contour cell blisters (7) – cardboard packs.
10 pcs. – contour cell blisters (1) – cardboard packs.
10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.
10 pcs. – contour cell blisters (4) – cardboard packs.
10 pcs. – contour cell blisters (5) – cardboard packs.
10 pcs. – contour cell blisters (6) – cardboard packs.
10 pcs. – contour cell blisters (7) – cardboard packs.
14 pcs. – contour cell blisters (1) – cardboard packs.
14 pcs. – contour cell blisters (2) – cardboard packs.
14 pcs. – contour cell blisters (3) – cardboard packs.
14 pcs. – contour cell blisters (4) – cardboard packs.
14 pcs. – contour cell blisters (5) – cardboard packs.
14 pcs. – contour cell blisters (6) – cardboard packs.
14 pcs. – contour cell blisters (7) – cardboard packs.
60 pcs. – jars (1) – cardboard packs.
60 pcs. – bottles (1) – cardboard packs.

Moxonidine [Pranapharm, LLC (Russia)]
Film-coated tablets, 0.2 mg: 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 pcs.
Film-coated tablets, 0.3 mg: 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 pcs.
Film-coated tablets, 0.4 mg: 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 pcs.

Marketing Authorization Holder

Pranapharm, LLC (Russia)

Dosage Forms

	Moxonidine	Film-coated tablets, 0.2 mg: 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 pcs.
		Film-coated tablets, 0.3 mg: 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 pcs.
		Film-coated tablets, 0.4 mg: 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets white, round, biconvex, without a score; on the cross-section, the tablet is white or almost white.

	1 tab.
Moxonidine	0.2 mg

Excipients: lactose monohydrate, microcrystalline cellulose (type 102), povidone K25, crospovidone, magnesium stearate.

Film coating composition: hypromellose, titanium dioxide (E171), macrogol 400, dimethicone 100.

10 pcs. – contour cell blisters (1) – cardboard packs.
10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.
10 pcs. – contour cell blisters (4) – cardboard packs.
10 pcs. – contour cell blisters (5) – cardboard packs.
10 pcs. – contour cell blisters (6) – cardboard packs.
10 pcs. – contour cell blisters (7) – cardboard packs.
10 pcs. – contour cell blisters (8) – cardboard packs.
10 pcs. – contour cell blisters (9) – cardboard packs.
10 pcs. – contour cell blisters (10) – cardboard packs.

Film-coated tablets yellow, round, biconvex, without a score; on the cross-section, two layers are visible, the inner layer is white or almost white.

	1 tab.
Moxonidine	0.3 mg

Excipients: lactose monohydrate, microcrystalline cellulose (type 102), povidone K25, crospovidone, magnesium stearate.

Film coating composition: hypromellose, titanium dioxide (E171), macrogol 400, dimethicone 100, iron oxide yellow dye (E172).

10 pcs. – contour cell blisters (1) – cardboard packs.
10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.
10 pcs. – contour cell blisters (4) – cardboard packs.
10 pcs. – contour cell blisters (5) – cardboard packs.
10 pcs. – contour cell blisters (6) – cardboard packs.
10 pcs. – contour cell blisters (7) – cardboard packs.
10 pcs. – contour cell blisters (8) – cardboard packs.
10 pcs. – contour cell blisters (9) – cardboard packs.
10 pcs. – contour cell blisters (10) – cardboard packs.

Film-coated tablets white, round, biconvex, without a score; on the cross-section, the tablet is white or almost white.

	1 tab.
Moxonidine	0.4 mg

Excipients: lactose monohydrate, microcrystalline cellulose (type 102), povidone K25, crospovidone, magnesium stearate.

Film coating composition: hypromellose, titanium dioxide (E171), macrogol 400, dimethicone 100.

10 pcs. – contour cell blisters (1) – cardboard packs.
10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.
10 pcs. – contour cell blisters (4) – cardboard packs.
10 pcs. – contour cell blisters (5) – cardboard packs.
10 pcs. – contour cell blisters (6) – cardboard packs.
10 pcs. – contour cell blisters (7) – cardboard packs.
10 pcs. – contour cell blisters (8) – cardboard packs.
10 pcs. – contour cell blisters (9) – cardboard packs.
10 pcs. – contour cell blisters (10) – cardboard packs.

Moxonidine [Pharmtekhnologiya LLC (Republic of Belarus)]
Film-coated tablets, 0.2 mg: 20 or 30 pcs.
Film-coated tablets, 0.3 mg: 20 or 30 pcs.
Film-coated tablets, 0.4 mg: 20 or 30 pcs.

Marketing Authorization Holder

Pharmtekhnologiya LLC (Republic of Belarus)

Dosage Forms

	Moxonidine	Film-coated tablets, 0.2 mg: 20 or 30 pcs.
		Film-coated tablets, 0.3 mg: 20 or 30 pcs.
		Film-coated tablets, 0.4 mg: 20 or 30 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets white, round, biconvex, without a score.

	1 tab.
Moxonidine	0.2 mg

Excipients: povidone (K-30), crospovidone, corn starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate.

Film coating composition hypromellose, macrogol 400, titanium dioxide.

10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.

Film-coated tablets pink, round, biconvex, without a score.

	1 tab.
Moxonidine	0.3 mg

Excipients: povidone (K-30), crospovidone, corn starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate.

Film coating composition hypromellose, macrogol 400, iron oxide red dye, titanium dioxide.

10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.

Film-coated tablets white, round, biconvex, with a score on one side.

	1 tab.
Moxonidine	0.4 mg

Excipients: povidone (K-30), crospovidone, corn starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate.

Film coating composition hypromellose, macrogol 400, titanium dioxide.

10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.

Moxonidine Alfactiv [Rif LLC (Russia)]
Film-coated tablets 0.2 mg
Film-coated tablets 0.4 mg

Marketing Authorization Holder

Rif LLC (Russia)

Manufactured By

Ozon, LLC (Russia)

Dosage Forms

	Moxonidine Alfactiv	Film-coated tablets 0.2 mg
		Film-coated tablets 0.4 mg

Dosage Form, Packaging, and Composition

Film-coated tablets

	1 tab.
Moxonidine	0.2 mg

10 pcs. – contour cell blisters – cardboard packs (10 pcs.) – Prescription only
10 pcs. – contour cell blisters (10 pcs.) – cardboard packs (100 pcs.) – Prescription only
10 pcs. – contour cell blisters (2 pcs.) – cardboard packs (20 pcs.) – Prescription only
10 pcs. – contour cell blisters (3 pcs.) – cardboard packs (30 pcs.) – Prescription only
10 pcs. – contour cell blisters (4 pcs.) – cardboard packs (40 pcs.) – Prescription only
10 pcs. – contour cell blisters (5 pcs.) – cardboard packs (50 pcs.) – Prescription only
10 pcs. – contour cell blisters (6 pcs.) – cardboard packs (60 pcs.) – Prescription only
10 pcs. – contour cell blisters (7 pcs.) – cardboard packs (70 pcs.) – Prescription only
10 pcs. – contour cell blisters (8 pcs.) – cardboard packs (80 pcs.) – Prescription only
10 pcs. – contour cell blisters (9 pcs.) – cardboard packs (90 pcs.) – Prescription only
14 pcs. – contour cell blisters – cardboard packs (14 pcs.) – Prescription only
14 pcs. – contour cell blisters (10 pcs.) – cardboard packs (140 pcs.) – Prescription only
14 pcs. – contour cell blisters (2 pcs.) – cardboard packs (28 pcs.) – Prescription only
14 pcs. – contour cell blisters (3 pcs.) – cardboard packs (42 pcs.) – Prescription only
14 pcs. – contour cell blisters (4 pcs.) – cardboard packs (56 pcs.) – Prescription only
14 pcs. – contour cell blisters (5 pcs.) – cardboard packs (70 pcs.) – Prescription only
14 pcs. – contour cell blisters (6 pcs.) – cardboard packs (84 pcs.) – Prescription only
14 pcs. – contour cell blisters (7 pcs.) – cardboard packs (98 pcs.) – Prescription only
14 pcs. – contour cell blisters (8 pcs.) – cardboard packs (112 pcs.) – Prescription only
14 pcs. – contour cell blisters (9 pcs.) – cardboard packs (126 pcs.) – Prescription only
30 pcs. – contour cell blisters – cardboard packs (30 pcs.) – Prescription only
30 pcs. – contour cell blisters (10 pcs.) – cardboard packs (300 pcs.) – Prescription only
30 pcs. – contour cell blisters (2 pcs.) – cardboard packs (60 pcs.) – Prescription only
30 pcs. – contour cell blisters (3 pcs.) – cardboard packs (90 pcs.) – Prescription only
30 pcs. – contour cell blisters (4 pcs.) – cardboard packs (120 pcs.) – Prescription only
30 pcs. – contour cell blisters (5 pcs.) – cardboard packs (150 pcs.) – Prescription only
30 pcs. – contour cell blisters (6 pcs.) – cardboard packs (180 pcs.) – Prescription only
30 pcs. – contour cell blisters (7 pcs.) – cardboard packs (210 pcs.) – Prescription only
30 pcs. – contour cell blisters (8 pcs.) – cardboard packs (240 pcs.) – Prescription only
30 pcs. – contour cell blisters (9 pcs.) – cardboard packs (270 pcs.) – Prescription only
7 pcs. – contour cell blisters – cardboard packs (7 pcs.) – Prescription only
7 pcs. – contour cell blisters (10 pcs.) – cardboard packs (70 pcs.) – Prescription only
7 pcs. – contour cell blisters (2 pcs.) – cardboard packs (14 pcs.) – Prescription only
7 pcs. – contour cell blisters (3 pcs.) – cardboard packs (21 pcs.) – Prescription only
7 pcs. – contour cell blisters (4 pcs.) – cardboard packs (28 pcs.) – Prescription only
7 pcs. – contour cell blisters (5 pcs.) – cardboard packs (35 pcs.) – Prescription only
7 pcs. – contour cell blisters (6 pcs.) – cardboard packs (42 pcs.) – Prescription only
7 pcs. – contour cell blisters (7 pcs.) – cardboard packs (49 pcs.) – Prescription only
7 pcs. – contour cell blisters (8 pcs.) – cardboard packs (56 pcs.) – Prescription only
7 pcs. – contour cell blisters (9 pcs.) – cardboard packs (63 pcs.) – Prescription only

Film-coated tablets

	1 tab.
Moxonidine	0.4 mg

Moxonidine Avexima [Avexima JSC (Russia)]
Film-coated tablets, 0.2 mg: 10, 20, 30, 50, 60 or 100 pcs.
Film-coated tablets, 0.3 mg: 10, 20, 30, 50, 60 or 100 pcs.
Film-coated tablets, 0.4 mg: 10, 20, 30, 50, 60 or 100 pcs.

Marketing Authorization Holder

Avexima JSC (Russia)

Manufactured By

Irbit Chemical Pharmaceutical Plant, JSC (Russia)

Dosage Forms

	Moxonidine Avexima	Film-coated tablets, 0.2 mg: 10, 20, 30, 50, 60 or 100 pcs.
		Film-coated tablets, 0.3 mg: 10, 20, 30, 50, 60 or 100 pcs.
		Film-coated tablets, 0.4 mg: 10, 20, 30, 50, 60 or 100 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets pale pink in color, round, biconvex in shape; the cross-section is white or almost white.

	1 tab.
Moxonidine	0.2 mg

Excipients: lactose monohydrate – 95.8 mg, povidone K-30 – 0.7 mg, crospovidone – 3 mg, magnesium stearate – 0.3 mg.

Film coating composition: hypromellose – 2.5 mg, macrogol 6000 – 0.25 mg, talc – 0.9975 mg, iron oxide red dye – 0.0025 mg, titanium dioxide – 1.25 mg.

10 pcs. – contour cell packs (1) – cardboard packs.
10 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
10 pcs. – contour cell packs (10) – cardboard packs.
10 pcs. – jars (1) – cardboard packs.
20 pcs. – jars (1) – cardboard packs.
30 pcs. – jars (1) – cardboard packs.
60 pcs. – jars (1) – cardboard packs.

Film-coated tablets pink in color, round, biconvex in shape; the cross-section is white or almost white.

	1 tab.
Moxonidine	0.3 mg

Excipients: lactose monohydrate – 95.7 mg, povidone K-30 – 0.7 mg, crospovidone – 3 mg, magnesium stearate – 0.3 mg.

Film coating composition: hypromellose – 2.5 mg, macrogol 6000 – 0.25 mg, talc – 0.975 mg, iron oxide red dye – 0.025 mg, titanium dioxide – 1.25 mg.

Film-coated tablets brownish-pink in color, round, biconvex in shape; the cross-section is white or almost white.

	1 tab.
Moxonidine	0.4 mg

Excipients: lactose monohydrate – 95.6 mg, povidone K-30 – 0.7 mg, crospovidone – 3 mg, magnesium stearate – 0.3 mg.

Film coating composition: hypromellose – 2.5 mg, macrogol 6000 – 0.25 mg, talc – 0.875 mg, iron oxide red dye – 0.125 mg, titanium dioxide – 1.25 mg.

Moxonidine Canon [Canonpharma Production, CJS (Russia)]
Film-coated tablets, 0.2 mg: 14, 28, 30, 40, 56, 60 or 90 pcs.
Film-coated tablets, 0.3 mg: 14, 28, 30, 40, 56, 60 or 90 pcs.
Film-coated tablets, 0.4 mg: 14, 28, 30, 40, 56, 60 or 90 pcs.

Marketing Authorization Holder

Canonpharma Production, CJS (Russia)

Dosage Forms

	Moxonidine Canon	Film-coated tablets, 0.2 mg: 14, 28, 30, 40, 56, 60 or 90 pcs.
		Film-coated tablets, 0.3 mg: 14, 28, 30, 40, 56, 60 or 90 pcs.
		Film-coated tablets, 0.4 mg: 14, 28, 30, 40, 56, 60 or 90 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets pink in color, round, biconvex; the cross-section is almost white; slight roughness is allowed.

	1 tab.
Moxonidine	0.2 mg

Excipients: hypromellose (low-substituted hydroxypropyl cellulose) – 3 mg, mannitol – 68 mg, croscarmellose sodium – 3.3 mg, magnesium stearate – 0.5 mg, microcrystalline cellulose – 25 mg.

Film coating composition: Opadry II 85F240021 pink – 3 mg, incl.: polyvinyl alcohol – 1.2 mg, macrogol (polyethylene glycol) – 0.606 mg, talc – 0.444 mg, titanium dioxide – 0.7206 mg, sunset yellow FCF dye – 0.0003 mg, indigo carmine dye – 0.0045 mg, ponceau 4R dye – 0.0246 mg.

7 pcs. – contour cell packs (2) – cardboard packs.
7 pcs. – contour cell packs (4) – cardboard packs.
7 pcs. – contour cell packs (8) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (4) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
30 pcs. – contour cell packs (1) – cardboard packs.
30 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (3) – cardboard packs.
30 pcs. – polymer jars (1) – cardboard packs.
60 pcs. – polymer jars (1) – cardboard packs.
90 pcs. – polymer jars (1) – cardboard packs.

Film-coated tablets dark pink in color, round, biconvex; the cross-section is almost white; slight roughness is allowed.

	1 tab.
Moxonidine	0.3 mg

Excipients: hypromellose (low-substituted hydroxypropyl cellulose) – 3.6 mg, mannitol – 81.5 mg, croscarmellose sodium – 4 mg, magnesium stearate – 0.6 mg, microcrystalline cellulose – 30 mg.

Film coating composition: Opadry II 85F240065 pink – 3.5 mg, incl.: polyvinyl alcohol – 1.4 mg, macrogol (polyethylene glycol) – 0.707 mg, talc – 0.518 mg, titanium dioxide – 0.6626 mg, sunset yellow FCF dye – 0.0889 mg, indigo carmine dye – 0.0507 mg, ponceau 4R dye – 0.0728 mg.

Film-coated tablets pink in color, round, biconvex; the cross-section is almost white; slight roughness is allowed.

	1 tab.
Moxonidine	0.4 mg

Excipients: hypromellose (low-substituted hydroxypropyl cellulose) – 4.2 mg, mannitol – 95 mg, croscarmellose sodium – 4.7 mg, magnesium stearate – 0.7 mg, microcrystalline cellulose – 35 mg.

Film coating composition: Opadry II 85F240021 pink – 4 mg, incl.: polyvinyl alcohol – 1.6 mg, macrogol (polyethylene glycol) – 0.808 mg, talc – 0.592 mg, titanium dioxide – 0.9608 mg, sunset yellow FCF dye – 0.0004 mg, indigo carmine dye – 0.006 mg, ponceau 4R dye – 0.0328 mg.

Moxonidine FT [Pharmtekhnologiya LLC (Republic of Belarus)]
Film-coated tablets 0.2 mg: 20 or 30 pcs.
Film-coated tablets 0.3 mg: 20 or 30 pcs.
Film-coated tablets 0.4 mg: 20 or 30 pcs.

Marketing Authorization Holder

Pharmtekhnologiya LLC (Republic of Belarus)

Dosage Forms

	Moxonidine FT	Film-coated tablets 0.2 mg: 20 or 30 pcs.
		Film-coated tablets 0.3 mg: 20 or 30 pcs.
		Film-coated tablets 0.4 mg: 20 or 30 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets white in color, round, biconvex.

	1 tab.
Moxonidine	0.2 mg

Excipients: povidone K30, crospovidone, corn starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate.
Tablet coating: hypromellose, macrogol 400, titanium dioxide (E171).

10 pcs. – contour cell pack (2) – cardboard packs with leaflet.
10 pcs. – contour cell pack (3) – cardboard packs with leaflet.

Film-coated tablets pink in color, round, biconvex.

	1 tab.
Moxonidine	0.3 mg

Excipients: povidone K30, crospovidone, corn starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate.
Tablet coating: hypromellose, macrogol 400, iron oxide red (E172), titanium dioxide (E171).

10 pcs. – contour cell pack (2) – cardboard packs with leaflet.
10 pcs. – contour cell pack (3) – cardboard packs with leaflet.

Film-coated tablets white in color, round, biconvex with a score on one side.

	1 tab.
Moxonidine	0.4 mg

Excipients: povidone K30, crospovidone, corn starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate.
Tablet coating: hypromellose, macrogol 400, titanium dioxide (E171).

10 pcs. – contour cell pack (2) – cardboard packs with leaflet.
10 pcs. – contour cell pack (3) – cardboard packs with leaflet.

Moxonidine Hexal [Hexal AG (Germany)]
Coated tablets, 200 mcg: 14, 28, or 30 pcs.

Marketing Authorization Holder

Hexal AG (Germany)

Manufactured By

Salutas Pharma, GmbH (Germany)

Dosage Form

Moxonidine Hexal

Coated tablets, 200 mcg: 14, 28, or 30 pcs.

Dosage Form, Packaging, and Composition

Coated tablets	1 tab.
Moxonidine	200 mcg

14 pcs. – contour cell packs (1) – cardboard packs.
14 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.

Moxonidine Hexal [Hexal AG (Germany)]
Coated tablets, 300 mcg: 14, 28, or 30 pcs.

Marketing Authorization Holder

Hexal AG (Germany)

Manufactured By

Salutas Pharma, GmbH (Germany)

Dosage Form

Moxonidine Hexal

Coated tablets, 300 mcg: 14, 28, or 30 pcs.

Dosage Form, Packaging, and Composition

Coated tablets	1 tab.
Moxonidine	300 mcg

14 pcs. – contour cell packs (1) – cardboard packs.
14 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.

Moxonidine Hexal [Hexal AG (Germany)]
Film-coated tablets, 400 mcg: 14, 28, or 30 pcs.

Marketing Authorization Holder

Hexal AG (Germany)

Manufactured By

Salutas Pharma, GmbH (Germany)

Dosage Form

Moxonidine Hexal

Film-coated tablets, 400 mcg: 14, 28, or 30 pcs.

Dosage Form, Packaging, and Composition

Coated tablets	1 tab.
Moxonidine	400 mcg

14 pcs. – contour cell packs (1) – cardboard packs.
14 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.

Moxonidine Renewal [Obnovlenie Pfc, JSC (Russia)]
Film-coated tablets, 0.2 mg: 14, 28, 30, 56, 60 or 90 pcs.
Film-coated tablets, 0.4 mg: 14, 28, 30, 56, 60 or 90 pcs.

Marketing Authorization Holder

Obnovlenie Pfc, JSC (Russia)

Dosage Forms

	Moxonidine Renewal	Film-coated tablets, 0.2 mg: 14, 28, 30, 56, 60 or 90 pcs.
		Film-coated tablets, 0.4 mg: 14, 28, 30, 56, 60 or 90 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets from pale pink to pink in color, round, biconvex; surface roughness is allowed; the cross-section shows a core of white or almost white color.

	1 tab.
Moxonidine	0.2 mg

Excipients: lactose monohydrate, croscarmellose sodium, povidone K30, magnesium stearate.

Film coating composition: OPADRY^® COMPLETE FILM COATING SYSTEM 13F240000 PINK[hypromellose, talc, titanium dioxide, macrogol 6000, polysorbate 80 (tween 80), ponceau 4R dye (E124), quinoline yellow dye (E104)].

10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
10 pcs. – contour cell pack (9) – cardboard pack.
14 pcs. – contour cell pack (1) – cardboard pack.
14 pcs. – contour cell pack (2) – cardboard pack.
14 pcs. – contour cell pack (4) – cardboard pack.
15 pcs. – contour cell pack (2) – cardboard pack.
15 pcs. – contour cell pack (4) – cardboard pack.
15 pcs. – contour cell pack (6) – cardboard pack.

Film-coated tablets from pale pink to pink in color, round, biconvex; surface roughness is allowed; the cross-section shows a core of white or almost white color.

	1 tab.
Moxonidine	0.4 mg

Excipients: lactose monohydrate, croscarmellose sodium, povidone K30, magnesium stearate.

Moxonidine solopharm [Grotex, LLC (Russia)]
Film-coated tablets, 0.2 mg
Film-coated tablets, 0.3 mg
Film-coated tablets, 0.4 mg

Marketing Authorization Holder

Grotex, LLC (Russia)

Dosage Forms

	Moxonidine solopharm	Film-coated tablets, 0.2 mg
		Film-coated tablets, 0.3 mg
		Film-coated tablets, 0.4 mg

Dosage Form, Packaging, and Composition

Film-coated tablets

Moxonidine

0.2 mg

10 pcs. – contour cell packs – cardboard packs (10 pcs.) – By prescription
10 pcs. – contour cell packs (10 pcs.) – cardboard packs (100 pcs.) – By prescription
10 pcs. – contour cell packs (2 pcs.) – cardboard packs (20 pcs.) – By prescription
10 pcs. – contour cell packs (3 pcs.) – cardboard packs (30 pcs.) – By prescription
10 pcs. – contour cell packs (4 pcs.) – cardboard packs (40 pcs.) – By prescription
10 pcs. – contour cell packs (5 pcs.) – cardboard packs (50 pcs.) – By prescription
10 pcs. – contour cell packs (6 pcs.) – cardboard packs (60 pcs.) – By prescription
10 pcs. – contour cell packs (7 pcs.) – cardboard packs (70 pcs.) – By prescription
10 pcs. – contour cell packs (8 pcs.) – cardboard packs (80 pcs.) – By prescription
10 pcs. – contour cell packs (9 pcs.) – cardboard packs (90 pcs.) – By prescription
7 pcs. – contour cell packs – cardboard packs (7 pcs.) – By prescription
7 pcs. – contour cell packs (10 pcs.) – cardboard packs (70 pcs.) – By prescription
7 pcs. – contour cell packs (2 pcs.) – cardboard packs (14 pcs.) – By prescription
7 pcs. – contour cell packs (3 pcs.) – cardboard packs (21 pcs.) – By prescription
7 pcs. – contour cell packs (4 pcs.) – cardboard packs (28 pcs.) – By prescription
7 pcs. – contour cell packs (5 pcs.) – cardboard packs (35 pcs.) – By prescription
7 pcs. – contour cell packs (6 pcs.) – cardboard packs (42 pcs.) – By prescription
7 pcs. – contour cell packs (7 pcs.) – cardboard packs (49 pcs.) – By prescription
7 pcs. – contour cell packs (8 pcs.) – cardboard packs (56 pcs.) – By prescription
7 pcs. – contour cell packs (9 pcs.) – cardboard packs (63 pcs.) – By prescription

Film-coated tablets

Moxonidine

0.3 mg

Film-coated tablets

Moxonidine

0.4 mg

Moxonidine Velpharm [Elzapharm, LLC (Russia)]
Film-coated tablets 0.2 mg
Film-coated tablets 0.3 mg
Film-coated tablets 0.4 mg

Marketing Authorization Holder

Elzapharm, LLC (Russia)

Manufactured By

Velpharm, LLC (Russia)

Dosage Forms

	Moxonidine Velpharm	Film-coated tablets 0.2 mg
		Film-coated tablets 0.3 mg
		Film-coated tablets 0.4 mg

Dosage Form, Packaging, and Composition

Film-coated tablets

	1 tab.
Moxonidine	0.2 mg

10 pcs. – jars – cardboard packs (10 pcs.) – By prescription
10 pcs. – contour cell packs – cardboard packs (10 pcs.) – By prescription
10 pcs. – contour cell packs (10 pcs.) – cardboard packs (100 pcs.) – By prescription
10 pcs. – contour cell packs (2 pcs.) – cardboard packs (20 pcs.) – By prescription
10 pcs. – contour cell packs (3 pcs.) – cardboard packs (30 pcs.) – By prescription
10 pcs. – contour cell packs (4 pcs.) – cardboard packs (40 pcs.) – By prescription
10 pcs. – contour cell packs (5 pcs.) – cardboard packs (50 pcs.) – By prescription
10 pcs. – contour cell packs (6 pcs.) – cardboard packs (60 pcs.) – By prescription
10 pcs. – contour cell packs (7 pcs.) – cardboard packs (70 pcs.) – By prescription
10 pcs. – contour cell packs (8 pcs.) – cardboard packs (80 pcs.) – By prescription
10 pcs. – contour cell packs (9 pcs.) – cardboard packs (90 pcs.) – By prescription
100 pcs. – jars – cardboard packs (100 pcs.) – By prescription
112 pcs. – jars – cardboard packs (112 pcs.) – By prescription
126 pcs. – jars – cardboard packs (126 pcs.) – By prescription
14 pcs. – jars – cardboard packs (14 pcs.) – By prescription
14 pcs. – contour cell packs – cardboard packs (14 pcs.) – By prescription
14 pcs. – contour cell packs (10 pcs.) – cardboard packs (140 pcs.) – By prescription
14 pcs. – contour cell packs (2 pcs.) – cardboard packs (28 pcs.) – By prescription
14 pcs. – contour cell packs (3 pcs.) – cardboard packs (42 pcs.) – By prescription
14 pcs. – contour cell packs (4 pcs.) – cardboard packs (56 pcs.) – By prescription
14 pcs. – contour cell packs (5 pcs.) – cardboard packs (70 pcs.) – By prescription
14 pcs. – contour cell packs (6 pcs.) – cardboard packs (84 pcs.) – By prescription
14 pcs. – contour cell packs (7 pcs.) – cardboard packs (98 pcs.) – By prescription
14 pcs. – contour cell packs (8 pcs.) – cardboard packs (112 pcs.) – By prescription
14 pcs. – contour cell packs (9 pcs.) – cardboard packs (126 pcs.) – By prescription
140 pcs. – jars – cardboard packs (140 pcs.) – By prescription
20 pcs. – jars – cardboard packs (20 pcs.) – By prescription
21 pcs. – jars – cardboard packs (21 pcs.) – By prescription
28 pcs. – jars – cardboard packs (28 pcs.) – By prescription
30 pcs. – jars – cardboard packs (30 pcs.) – By prescription
35 pcs. – jars – cardboard packs (35 pcs.) – By prescription
40 pcs. – jars – cardboard packs (40 pcs.) – By prescription
42 pcs. – jars – cardboard packs (42 pcs.) – By prescription
49 pcs. – jars – cardboard packs (49 pcs.) – By prescription
50 pcs. – jars – cardboard packs (50 pcs.) – By prescription
56 pcs. – jars – cardboard packs (56 pcs.) – By prescription
60 pcs. – jars – cardboard packs (60 pcs.) – By prescription
63 pcs. – jars – cardboard packs (63 pcs.) – By prescription
7 pcs. – jars – cardboard packs (7 pcs.) – By prescription
7 pcs. – contour cell packs – cardboard packs (7 pcs.) – By prescription
7 pcs. – contour cell packs (10 pcs.) – cardboard packs (70 pcs.) – By prescription
7 pcs. – contour cell packs (2 pcs.) – cardboard packs (14 pcs.) – By prescription
7 pcs. – contour cell packs (3 pcs.) – cardboard packs (21 pcs.) – By prescription
7 pcs. – contour cell packs (4 pcs.) – cardboard packs (28 pcs.) – By prescription
7 pcs. – contour cell packs (5 pcs.) – cardboard packs (35 pcs.) – By prescription
7 pcs. – contour cell packs (6 pcs.) – cardboard packs (42 pcs.) – By prescription
7 pcs. – contour cell packs (7 pcs.) – cardboard packs (49 pcs.) – By prescription
7 pcs. – contour cell packs (8 pcs.) – cardboard packs (56 pcs.) – By prescription
7 pcs. – contour cell packs (9 pcs.) – cardboard packs (63 pcs.) – By prescription
70 pcs. – jars – cardboard packs (70 pcs.) – By prescription
80 pcs. – jars – cardboard packs (80 pcs.) – By prescription
84 pcs. – jars – cardboard packs (84 pcs.) – By prescription
90 pcs. – jars – cardboard packs (90 pcs.) – By prescription
98 pcs. – jars – cardboard packs (98 pcs.) – By prescription

Film-coated tablets

	1 tab.
Moxonidine	0.3 mg

Film-coated tablets

	1 tab.
Moxonidine	0.4 mg

Moxonidine-Akrikhin [Akrikhin Chemical and Pharmaceutical Plant, JSC (Russia)]
Film-coated tablets, 0.2 mg: 10, 20, 30, 50, or 60 pcs.
Film-coated tablets, 0.4 mg: 10, 20, 30, 50, or 60 pcs.

Marketing Authorization Holder

Akrikhin Chemical and Pharmaceutical Plant, JSC (Russia)

Dosage Forms

	Moxonidine-Akrikhin	Film-coated tablets, 0.2 mg: 10, 20, 30, 50, or 60 pcs.
		Film-coated tablets, 0.4 mg: 10, 20, 30, 50, or 60 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets from light pink to pink in color, round, biconvex; on the cross-section, the core is from white to white with a grayish or yellowish tint.

	1 tab.
Moxonidine	0.2 mg

Excipients: lactose monohydrate, povidone (type K90), crospovidone, magnesium stearate.

Film coating composition: ethylcellulose as a 30% aqueous dispersion, ready-made pink film coating [hypromellose, titanium dioxide, talc, macrogol 6000, iron oxide red].

Film-coated tablets from pink to pink with a brownish tint in color, round, biconvex; on the cross-section, the core is from white to white with a grayish or yellowish tint.

	1 tab.
Moxonidine	0.4 mg

Excipients: lactose monohydrate, povidone (type K90), crospovidone, magnesium stearate.

Film coating composition: ethylcellulose as a 30% aqueous dispersion, ready-made pink film coating [hypromellose, titanium dioxide, talc, macrogol 6000, iron oxide red].

Moxonidine-Alium [Aliym, JSC (Russia)]
Film-coated tablets, 200 mcg: 10, 14, 20, 28, 30, 40, 50, 60, or 90 pcs.
Film-coated tablets, 300 mcg: 10, 14, 20, 28, 30, 40, 50, 60, or 90 pcs.
Film-coated tablets, 400 mcg: 10, 14, 20, 28, 30, 40, 50, 60, or 90 pcs.

Marketing Authorization Holder

Aliym, JSC (Russia)

Dosage Forms

	Moxonidine-Alium	Film-coated tablets, 200 mcg: 10, 14, 20, 28, 30, 40, 50, 60, or 90 pcs.
		Film-coated tablets, 300 mcg: 10, 14, 20, 28, 30, 40, 50, 60, or 90 pcs.
		Film-coated tablets, 400 mcg: 10, 14, 20, 28, 30, 40, 50, 60, or 90 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets white or almost white in color, round, biconvex; on the fracture, the tablets are white or almost white in color; surface roughness of the tablets is allowed.

	1 tab.
Moxonidine	200 mcg

Excipients: lactose monohydrate, povidone, crospovidone, magnesium stearate, polyvinyl alcohol, macrogol, talc, titanium dioxide.

10 pcs. – contour cell packs (1) – cardboard packs.
10 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (4) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
14 pcs. – contour cell packs (1) – cardboard packs.
14 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (3) – cardboard packs.

Film-coated tablets yellow in color, round, biconvex; on the fracture, the tablets are white or almost white in color; surface roughness of the tablets is allowed.

	1 tab.
Moxonidine	300 mcg

Excipients: lactose monohydrate, povidone, crospovidone, magnesium stearate, polyvinyl alcohol, macrogol, titanium dioxide, talc, dye iron oxide yellow.

10 pcs. – contour cell packs (1) – cardboard packs.
10 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (4) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
14 pcs. – contour cell packs (1) – cardboard packs.
14 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (3) – cardboard packs.

Film-coated tablets pink in color, round, biconvex; on the fracture, the tablets are white or almost white in color; surface roughness of the tablets is allowed.

	1 tab.
Moxonidine	400 mcg

Excipients: lactose monohydrate, povidone, crospovidone, magnesium stearate, polyvinyl alcohol, macrogol, titanium dioxide, talc, dye iron oxide yellow, dye iron oxide red.

10 pcs. – contour cell packs (1) – cardboard packs.
10 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (4) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
14 pcs. – contour cell packs (1) – cardboard packs.
14 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (3) – cardboard packs.

Moxonidine-ALSI [Alsi Pharma, JSC (Russia)]
Film-coated tablets, 0.2 mg: 30 or 60 pcs.
Film-coated tablets, 0.4 mg: 30 or 60 pcs.

Marketing Authorization Holder

Alsi Pharma, JSC (Russia)

Dosage Forms

	Moxonidine-ALSI	Film-coated tablets, 0.2 mg: 30 or 60 pcs.
		Film-coated tablets, 0.4 mg: 30 or 60 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets from light pink to pink in color, round, biconvex; on the cross-section – the inner layer is white or almost white in color.

	1 tab.
Moxonidine	0.2 mg

Excipients: lactose monohydrate – 67.7 mg, crospovidone – 1.4 mg, magnesium stearate – 0.7 mg.

Coating composition Opadry II (85F240181) pink – 2.8 mg (polyvinyl alcohol – 1.12 mg, titanium dioxide – 0.683 mg, macrogol (polyethylene glycol) – 0.566 mg, talc – 0.414 mg, dye carmine red (E120) – 0.017 mg).

10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.

Film-coated tablets from light pink to pink in color, round, biconvex; on the cross-section – the inner layer is white or almost white in color.

	1 tab.
Moxonidine	0.4 mg

Excipients: lactose monohydrate – 135.4 mg, crospovidone – 2.8 mg, magnesium stearate – 1.4 mg.

Coating composition Opadry II (85F240181) pink – 5.6 mg (polyvinyl alcohol – 2.24 mg, titanium dioxide – 1.365 mg, macrogol (polyethylene glycol) – 1.131 mg, talc – 0.829 mg, dye carmine red (E120) – 0.035 mg).

10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.

Moxonidine-Citomed [MBNPK Cytomed, JSC (Russia)]
Film-coated tablets 0.2 mg
Film-coated tablets 0.3 mg
Film-coated tablets 0.4 mg

Marketing Authorization Holder

MBNPK Cytomed, JSC (Russia)

Manufactured By

Tatkhimpharmpreparaty, JSC (Russia)

Dosage Forms

	Moxonidine-Citomed	Film-coated tablets 0.2 mg
		Film-coated tablets 0.3 mg
		Film-coated tablets 0.4 mg

Dosage Form, Packaging, and Composition

Film-coated tablets

	1 tab.
Moxonidine	0.2 mg

14 pcs. – contour cell packs (2 pcs.) – cardboard packs (28 pcs.) – By prescription
15 pcs. – contour cell packs (2 pcs.) – cardboard packs (30 pcs.) – By prescription
15 pcs. – contour cell packs (4 pcs.) – cardboard packs (60 pcs.) – By prescription
15 pcs. – contour cell packs (6 pcs.) – cardboard packs (90 pcs.) – By prescription

Film-coated tablets

	1 tab.
Moxonidine	0.3 mg

Film-coated tablets

	1 tab.
Moxonidine	0.4 mg

Moxonidine-LF [Lekpharm, SOOO (Republic of Belarus)]
Film-coated tablets, 0.2 mg: 30 pcs.
Film-coated tablets, 0.4 mg: 30 pcs.

Marketing Authorization Holder

Lekpharm, SOOO (Republic of Belarus)

Dosage Forms

	Moxonidine-LF	Film-coated tablets, 0.2 mg: 30 pcs.
		Film-coated tablets, 0.4 mg: 30 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets light pink in color, round, biconvex in shape.

	1 tab.
Moxonidine	0.2 mg

Excipients: crospovidone (type B) – 3 mg, magnesium stearate – 0.5 mg, lactose monohydrate – 96.3 mg.

Film coating composition Opadry II pink (85F240029) – 3 mg, consisting of: partially hydrolyzed polyvinyl alcohol – 40%, titanium dioxide (E171) – 22.77%, macrogol 4000 – 20.2%, talc – 14.8%, dye iron oxide red (E172) – 0.16%, dye iron oxide yellow (E172) – 0.07%.

10 pcs. – contour cell packs (3) – cardboard packs.

Film-coated tablets reddish-brown in color, round, biconvex in shape.

	1 tab.
Moxonidine	0.4 mg

Excipients: crospovidone (type B) – 3 mg, magnesium stearate – 0.5 mg, lactose monohydrate – 96.1 mg.

Film coating composition Opadry II red (85F35222) – 3 mg, consisting of: partially hydrolyzed polyvinyl alcohol – 40%, titanium dioxide (E171) – 10.35%, macrogol 4000 – 20.2%, talc – 14.8%, dye iron oxide red (E172) – 8.15%, dye iron oxide yellow (E172) – 6.2%, dye iron oxide black (E172) – 0.3%.

10 pcs. – contour cell packs (3) – cardboard packs.

Moxonidine-Teva [Teva, LLC (Russia)]
Film-coated tablets 0.2 mg: 10, 20, 30, 40, 50, 60, 70, 80, or 90 pcs.
Film-coated tablets 0.4 mg: 10, 20, 30, 40, 50, 60, 70, 80, or 90 pcs.

Marketing Authorization Holder

Teva, LLC (Russia)

Manufactured By

Rubicon, LLC (Republic of Belarus)

Dosage Forms

	Moxonidine-Teva	Film-coated tablets 0.2 mg: 10, 20, 30, 40, 50, 60, 70, 80, or 90 pcs.
		Film-coated tablets 0.4 mg: 10, 20, 30, 40, 50, 60, 70, 80, or 90 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets white in color, cylindrical, biconvex.

	1 tab.
Moxonidine	0.2 mg

Excipients: microcrystalline cellulose, povidone K30, sodium starch glycolate (type A), magnesium stearate, lactose monohydrate, film coating Opadry II white 85F18422 (polyvinyl alcohol, macrogol, talc, titanium dioxide (E171)).

10 pcs. – contour cell pack (1) – cardboard packs.
10 pcs. – contour cell pack (2) – cardboard packs.
10 pcs. – contour cell pack (3) – cardboard packs.
10 pcs. – contour cell pack (4) – cardboard packs.
10 pcs. – contour cell pack (5) – cardboard packs.
10 pcs. – contour cell pack (6) – cardboard packs.
10 pcs. – contour cell pack (7) – cardboard packs.
10 pcs. – contour cell pack (8) – cardboard packs.
10 pcs. – contour cell pack (9) – cardboard packs.

Film-coated tablets white in color, cylindrical, biconvex.

	1 tab.
Moxonidine	0.4 mg

Medixlife (Author)

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