Nonoxinol (Suppositories) Instructions for Use

ATC Code

G02BB (Intravaginal contraceptives)

Active Substance

Nonoxinol (Rec.INN registered by WHO)

Clinical-Pharmacological Group

Vaginal contraceptive with spermicidal action

Pharmacotherapeutic Group

Other agents used in gynecology; contraceptives for topical use; intravaginal contraceptives

Pharmacological Action

A contraceptive agent. It has a pronounced spermicidal effect.

It causes fragmentation, reduced motility, and death of spermatozoa.

It also has antimicrobial, antifungal, antiviral, and antiparasitic effects against a number of pathogens that cause sexually transmitted diseases.

Indications

• Local contraception for women of reproductive age.
• Use in the presence of contraindications to hormonal or intrauterine contraception.
• Employ for irregular sexual contacts.
• Apply when using medications that reduce the effectiveness of hormonal contraception.
• Utilize following a missed or delayed dose of regularly used oral contraceptives.

ICD codes

Dosage Regimen

Insert one suppository deeply into the vagina 10 to 15 minutes before each sexual intercourse to allow for complete dissolution and distribution.

For repeated intercourse, insert a new suppository each time. The protective effect is limited to approximately one hour after insertion. Do not douche for at least 6 hours after the last intercourse.

Suppositories

Apply intravaginally.

Adverse Reactions

Local reactions are possible, including increased vaginal discharge, itching, and burning in the vagina and/or on the partner’s penis. Vaginal dryness and painful urination may occur.

Allergic reactions, such as skin rash and urticaria, are also possible. Discontinue use if severe irritation or signs of hypersensitivity develop.

Contraindications

• Hypersensitivity to nonoxinol or any component of the suppository.
• Presence of vaginal bleeding of unknown origin.
• Anomalies in the development of the genital organs.
• Active vaginal infections, including vaginitis, cervicitis, or endometritis.
• Ulceration, irritation, or erosion of the vaginal mucosa or cervix.

Use in Pregnancy and Lactation

Nonoxinol is a contraceptive and is not used during pregnancy. During breastfeeding, it can be used as indicated in cases where the expected benefit to the mother outweighs the potential risk to the infant.

Geriatric Use

Not intended for use in the elderly.

Special Precautions

The product can be used for a long time.

The product can be used in combination with a condom.

Drug Interactions

Any other intravaginally administered medication may physically interfere with the distribution of the suppository and reduce its spermicidal effect.

Concurrent use of soaps or detergent-based solutions for vaginal douching can inactivate nonoxinol and compromise contraceptive efficacy. Avoid douching for at least 6 hours post-coitus.

Overdose

No specific antidote exists. Accidental ingestion is unlikely to cause systemic effects due to low absorption. In case of significant local irritation from excessive use, discontinue treatment and consult a physician. Treatment is supportive and symptomatic.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.