Pantomecol^® Plus (Cream) Instructions for Use

Marketing Authorization Holder

Nizhpharm JSC (Russia)

ATC Code

D08AC52 (Chlorhexidine in combination with other drugs)

Active Substances

Dexpanthenol (Rec.INN registered by WHO)

Chlorhexidine (Rec.INN registered by WHO)

Dosage Form

Pantomecol® Plus

External use cream 5.25%+0.802%: tubes 25 g, 30 g or 50 g

Dosage Form, Packaging, and Composition

Cream for external use white or almost white in color.

Excipients: propylene glycol, macrogol cetostearyl ether, cetostearyl alcohol [cetyl alcohol not more than 60%, stearyl alcohol not less than 40%], liquid paraffin, white soft paraffin, sodium phosphate dibasic dodecahydrate, potassium phosphate monobasic, purified water.

25 g – aluminum tubes (1) – cardboard packs.
30 g – aluminum tubes (1) – cardboard packs.
50 g – aluminum tubes (1) – cardboard packs.
25 g – laminated polyethylene tubes (1) – cardboard packs.
30 g – laminated polyethylene tubes (1) – cardboard packs.
50 g – laminated polyethylene tubes (1) – cardboard packs.

Clinical-Pharmacological Group

A drug improving trophism and tissue regeneration, with antimicrobial activity for external use

Pharmacotherapeutic Group

Antiseptics and disinfectants; biguanides and amidines

Pharmacological Action

A combined drug for external use. It has antimicrobial, anti-inflammatory action: improves tissue regeneration.

Dexpanthenol is rapidly converted in skin cells into pantothenic acid, which plays an important role in both the formation and healing of damaged skin.

Chlorhexidine is an antiseptic, active against vegetative forms of gram-negative and gram-positive bacteria, as well as yeasts, dermatophytes, and lipophilic viruses. It acts on bacterial spores only at elevated temperatures. It cleanses and disinfects the skin without causing damage. When applied to a wound surface, it protects against infection, promoting healing.

Indications

Minor wounds with a risk of infection (abrasions, scratches, minor cuts and scrapes, cracks, mild burns); infected superficial skin lesions; nipple cracks during breastfeeding; chronic wounds (e.g., trophic leg ulcers, bedsores); surgical wounds.

ICD codes

Dosage Regimen

Apply the cream externally to a previously cleansed wound or affected skin area.

Use the cream one to several times daily, depending on the severity of the condition.

For minor wounds like abrasions, scratches, and minor burns, apply a thin layer of cream.

For chronic wounds such as trophic ulcers or bedsores, apply the cream more generously.

Treat nipple cracks after each feeding, ensuring to gently remove any residual cream before the next feeding.

Perform wound treatment using either the open method or by applying an occlusive dressing.

When using a dressing, apply the cream and cover with a suitable sterile bandage; change the dressing as needed.

For surgical wounds, follow the specific instructions provided by the healthcare professional.

Avoid contact with eyes and mucous membranes.

Do not use on the auricle or in severe, heavily contaminated, or deep wounds requiring medical intervention.

If no improvement is seen within 10-14 days, or if symptoms worsen, discontinue use and consult a physician.

Adverse Reactions

Allergic reactions: urticaria, itching are possible.

Contraindications

For treatment of the auricle; in case of severe, deep and heavily contaminated wounds (such injuries require medical intervention); hypersensitivity to dexpanthenol and/or chlorhexidine.

Use in Pregnancy and Lactation

Can be used during pregnancy and breastfeeding, however, application to large skin areas should be avoided.

Geriatric Use

The drug is approved for use in elderly patients.

Special Precautions

Avoid contact with eyes of preparations containing Dexpanthenol/chlorhexidine.

Do not take orally.

Large area lesions, heavily contaminated and deep wounds, as well as bite and puncture wounds require medical intervention (due to the risk of tetanus).

If the wound size remains consistently large over time or the wound does not heal within 10-14 days, a doctor’s consultation is necessary. This is also necessary if the wound edges are severely hyperemic, the wound suddenly swells, severe pain appears, or the injury is accompanied by fever (due to the danger of sepsis development).

Drug Interactions

As a precaution regarding possible interaction (antagonism or inactivation), this combination should not be used simultaneously with other antiseptics.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.