Ringer-Acetate (Solution) Instructions for Use
ATC Code
B05BB01 (Electrolytes)
Clinical-Pharmacological Group
Drug for rehydration and detoxification for parenteral use
Pharmacotherapeutic Group
Blood substitutes and perfusion solutions; solutions for intravenous administration; solutions affecting water-electrolyte balance
Pharmacological Action
A combined drug that eliminates metabolic acidosis and normalizes the acid-base and water-electrolyte composition of the blood.
The therapeutic effect of the drug is due to a temporary increase in the volume of circulating blood, replenishment of the deficiency of sodium, potassium, and calcium, as well as the conversion of the acetate ion into bicarbonate.
Indications
Shock; thermal injury; acute blood loss; hypohydration (isotonic and hypotonic forms); metabolic acidosis; acute diffuse peritonitis; intestinal obstruction (to correct water and salt balance); decompensation of electrolyte disturbances in patients with intestinal fistulas; therapeutic plasmapheresis (dialysis-filtration method).
ICD codes
| ICD-10 code | Indication |
| E86 | Volume depletion (including dehydration, hypovolemia) |
| E87.2 | Acidosis |
| K56.6 | Other and unspecified intestinal obstruction |
| K63.2 | Fistula of intestine |
| K65.0 | Acute peritonitis (including abscess) |
| R57.0 | Cardiogenic shock |
| R57.1 | Hypovolemic shock |
| R57.2 | Septic shock |
| R57.8 | Other types of shock |
| R58 | Hemorrhage, not elsewhere classified |
| T30 | Burns and corrosions of unspecified body region |
| T79.4 | Traumatic shock |
| ICD-11 code | Indication |
| 1G41 | Sepsis with septic shock |
| 5C70.Z | Decrease of volume of fluid [hypovolemia], unspecified |
| 5C73.Z | Acidosis, unspecified |
| DA91.Z | Unspecified obstruction of small intestine |
| DA92.0 | Fistula of small intestine |
| DB30.Z | Unspecified obstruction of large intestine |
| DB31.0 | Fistula of large intestine |
| DC50.0 | Primary peritonitis |
| DC50.2 | Peritoneal abscess |
| DC50.Z | Peritonitis, unspecified |
| DE2Z | Diseases of the digestive system, unspecified |
| ME24.1 | Fistula of digestive system |
| MG27 | Hemorrhage, not elsewhere classified |
| MG40.0 | Cardiogenic shock |
| MG40.1 | Hypovolemic shock |
| MG40.Z | Shock, unspecified |
| NE11 | Burn of unspecified body region |
| NF0A.4 | Traumatic shock, not elsewhere classified |
Dosage Regimen
| The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen. |
Administer the solution by intravenous infusion only.
Determine the dosage and infusion rate individually based on the patient’s condition, degree of fluid and electrolyte deficit, age, and body weight.
For adults, the typical daily dose is 5-20 ml/kg of body weight.
In cases of severe fluid loss or shock, increase the adult dose to 30-40 ml/kg daily.
For pediatric patients, the daily dose is 5-10 ml/kg.
Adjust the infusion rate for children to 30-60 drops per minute; control the rate carefully to avoid circulatory overload.
In severe hypovolemia, use this solution as part of a combined therapy with colloidal solutions or blood products.
When administering large volumes or for prolonged therapy, monitor the patient’s clinical status, electrolyte levels in plasma and urine, acid-base balance, and renal function.
Do not administer if the solution is discolored or contains particulate matter.
Adverse Reactions
Systemic reactions: allergic reactions, when large volumes of solution are administered: hyperhydration, chloride acidosis, hypernatremia, hypokalemia.
Contraindications
Hypersensitivity; alkalosis; extracellular hyperhydration; hypertonic dehydration; hypernatremia; conditions in which the administration of large volumes of fluid is contraindicated: severe chronic heart failure, cerebral edema, pulmonary edema, anuria.
With caution
Heart failure, arterial hypertension, renal and/or hepatic insufficiency, oliguria.
Use in Hepatic Impairment
With caution in hepatic insufficiency.
Use in Renal Impairment
With caution in renal insufficiency.
Pediatric Use
The daily dose for children is 5-10 ml/kg, the rate of administration is 30-60 drops/min.
Special Precautions
When treating severe hypovolemia, simultaneous therapy with colloidal solutions, blood and its components is recommended (due to the short duration of action of the drug).
When administering large doses of the solution for a long time, it is advisable to monitor electrolytes in plasma and urine.
Drug Interactions
Increased sodium retention in the body is possible with simultaneous use of NSAIDs, androgens, estrogens, anabolic hormones, corticotropin, mineralocorticoids, vasodilators or ganglioblockers.
When taken with potassium-sparing diuretics – the development of hyperkalemia.
Calcium in combination with cardiac glycosides increases the likelihood of their toxic effects.
Storage Conditions
Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.
Dispensing Status
Rx Only
Important Safety Information
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.
Medical DisclaimerBrand (or Active Substance), Marketing Authorisation Holder, Dosage Form
Solution for infusion: bot. 250 ml or 500 ml
Marketing Authorization Holder
IST-Pharm, LLC (Russia)
Manufactured By
IST-Pharm, LLC (Russia)
Or
Pharmasintez-Tyumen, LLC (Russia)
Dosage Form
 |
Ringer-Acetate | Solution for infusion: bot. 250 ml or 500 ml |
Dosage Form, Packaging, and Composition
Solution for infusion in the form of a colorless, transparent liquid.
| 1 L | |
| Sodium chloride | 5.91 g |
| Sodium acetate calculated as anhydrous | 2.82 g |
| Potassium chloride | 0.3 g |
| Calcium chloride calculated as anhydrous | 0.22 g |
| Magnesium chloride calculated as anhydrous | 0.095 g |
| Ionic composition | |
| Sodium ion | 135 mmol |
| Potassium ion | 4 mmol |
| Calcium ion | 2 mmol |
| Magnesium ion | 1 mmol |
| Chloride ion | 108 mmol |
| Acetate ion | 34 mmol |
Excipients: water for injection – up to 1 L.
Theoretical osmolarity: 284 mOsmol/L.
250 ml – bottles (1) – cardboard boxes.
500 ml – bottles (1) – cardboard boxes.
250 ml – bottles (1) – sealed bags (1) – cardboard boxes.
500 ml – bottles (1) – sealed bags (1) – cardboard boxes.
Solution for infusion: containers 100 ml, 250 ml, 500 ml or 1000 ml.
Marketing Authorization Holder
KFK Medpolymer, LLC (Russia)
Dosage Form
|
Ringer-Acetate | Solution for infusion: containers 100 ml, 250 ml, 500 ml or 1000 ml. |
Dosage Form, Packaging, and Composition
| Solution for infusion | 1 L |
| Potassium chloride | 300 mg |
| Calcium chloride | 220 mg |
| Magnesium chloride | 95 mg |
| Sodium acetate | 2.82 g |
| Sodium chloride | 5.91 g |
100 ml – polymer containers (1) – polymer bags.
250 ml – polymer containers (1) – polymer bags.
500 ml – polymer containers (1) – polymer bags.
1000 ml – polymer containers (1) – polymer bags.
![Ringer-Acetate [Solution] 1](https://www.medixlife.com/wp-content/uploads/Medixlife_favi_512.png "Ringer-Acetate [Solution] 2")