Sementex (Solution, Cream) Instructions for Use

Instructions
Dosage forms

ATC Code

D03AX (Other drugs that promote normal scarring)

Clinical-Pharmacological Group

Drug that activates tissue metabolism, improves trophism and stimulates the regeneration process

Pharmacotherapeutic Group

Tissue regeneration stimulant

Pharmacological Action

Polydeoxyribonucleotide, obtained from trout milt.

It activates DNA synthesis, stimulates A-2 type receptors in the cell, enhances cellular proliferation and tissue metabolism, and activates the pentose phosphate pathway involved in cellular energy metabolism, which ensures the restoration of the structure and trophism of connective tissue, stimulation of collagen synthesis, and the formation of new tissue structure in scars of various etiologies.

It activates the engraftment processes of autografts during skin transplantation.

Pharmacokinetics

After intramuscular administration, T_max is 1 hour. C_max is 6.28 µg/ml.

It does not bind to plasma proteins.

It is metabolized at the plasma level by nonspecific DNases that adhere to the membranes of various cellular structures and break down Polydeoxyribonucleotide into oligo- and mononucleotides.

T_1/2 is 3 hours. T_1/2 of the α-phase is 24 minutes, of the β-phase is 150 minutes.

It is excreted mainly in the urine (65%) and in the feces. It does not accumulate.

Indications

Mechanical injuries with violation of the integrity of the skin; trophic ulcers; thermal burns of II-III degree; anal fissures and fissures of the mammary gland nipples; engraftment of skin grafts.

Aesthetic medicine: rejuvenation of the skin of the face and neck; skin restoration in the post-peeling period; stimulation of collagen synthesis in fine wrinkles; elimination of striae by the method of local infiltration.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
K60	Fissure and fistula of anus and rectum
L90.6	Atrophic striae
L90.9	Unspecified atrophic skin change
L98.4	Chronic skin ulcer, not elsewhere classified
N64.0	Fissure and fistula of nipple
T14	Injuries to unspecified parts of body
T30	Burns and corrosions of unspecified body region
Z94.6	Presence of transplanted bone

ICD-11 code	Indication
DB50.Z	Fissure or fistula of anal region, unspecified
DE2Z	Diseases of the digestive system, unspecified
EA40	Tropical phagedenic ulcer
EE40.1Z	Striae of skin, unspecified
EE40.Z	Atrophy or degeneration of connective tissue of dermis or subcutaneous fat, unspecified
EF60	Ischemic ulceration of the skin
EM0Z	Unspecified skin disorder
GB23.1	Fissure or fistula of nipple
ME60.2	Ulcerative skin lesion of unspecified nature
ND56.Z	Unspecified injury of unspecified part of trunk, limb or body region
NE11	Burn of unspecified body region
QB63.5	Presence of transplanted bone

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Solution, Cream

Intramuscularly, subcutaneously, externally.

Intramuscularly and subcutaneously, 3 ml every other day. The course of treatment is 15-20 days.

When using the local infiltration method: 3 ml once a day. The course is 5-7 procedures.

Externally: apply a thin layer to the affected surface 1-2 times a day. The duration of treatment is determined by the clinical picture.

Adverse Reactions

Allergic reactions.

Contraindications

Hypersensitivity; children under 16 years of age.

Use in Pregnancy and Lactation

Use with caution during pregnancy and lactation (breastfeeding).

Pediatric Use

Contraindicated in children under 16 years of age.

Special Precautions

It is recommended to combine the use of the injectable form of the drug with the external use of the cream. When treating contaminated and infected wounds, the drug should be used in complex therapy with antiseptics and/or antibiotics.

Drug Interactions

It enhances the action of hyaluronic acid.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer