Azitral, 500 mg capsules, 3 pcs.

Composition

1 capsule contains azithromycin 500 mg

Pharmacological action

Azitral is a broad-spectrum antibiotic. It is a representative of the subgroup of macrolide antibiotics-azalides. When creating high concentrations in the focus of inflammation, it has a bactericidal effect.

Gram-positive cocci are susceptible to azithromycin: Streptococcus pneumoniae, St. pyogenes, St. agalactiae, CF and G group streptococci, Staphylococcus aureus, St. viridans; gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, B. parapertussis, Legionella pneumophila, H. ducrei, Campylobacter jejuni, Helicobacter Pylori, Neisseria gonorrhoeae and Gardnerella vaginalis; some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp; and Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Azithromycin is inactive against gram-positive bacteria resistant to erythromycin.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• Infections of the upper respiratory tract and ENT organs (sore throat, sinusitis, tonsillitis, pharyngitis, otitis media);
• Scarlet fever;
• Lower respiratory tract infections (bacterial and atypical pneumonia, bronchitis);
• Infections of the skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses);
• Infections of the urogenital tract (gonorrheal and non-gonorrheal urethritis and / or cervicitis);
• Lyme disease (borreliosis), for the treatment of the initial stage (erythema migrans);
• Stomach and duodenal diseases associated with Helicobacter Pylori (as part of combination therapy).

Contraindications

Hypersensitivity (including to other macrolides), hepatic and / or renal failure, lactation period.

With caution-pregnancy (can be used in cases where the benefit of its use significantly exceeds the risk that always exists when using any drug during pregnancy), arrhythmia (possible ventricular arrhythmias and prolongation of the QT interval), children under 16 years of age, children with severe liver or kidney dysfunction.

Side effects

From the digestive system: when taken orally – diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less – dyspepsia, flatulence, vomiting, melena, cholestatic jaundice, increased activity of “liver” transaminases; in addition, in children – constipation, anorexia, gastritis; candidiasis of the oral mucosa (with intravenous administration).

From the cardiovascular system: palpitations, chest pain (1% or less).

Nervous system disorders: dizziness, headache, vertigo, drowsiness; in children-headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disorders (1% or less).

From the genitourinary system: vaginal candidiasis, nephritis (1% or less).

Allergic reactions: rash, photosensitivity, quincke’s edema

Interaction

Antacids (aluminum and magnesium-containing ones), ethanol, and food slow and reduce absorption. When warfarin and azithromycin were co-administered (in normal doses), no changes in prothrombin time were detected, however, given that the interaction of macrolides and warfarin may increase the anticoagulation effect, patients should carefully monitor prothrombin time. Digoxin: increased digoxin concentration.

Ergotamine and dihydroergotamine: increased toxic effects (vasospasm, dysesthesia). Triazolam: reduced clearance and increased pharmacological action of triazolan. Slows down the elimination and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, as well as drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine phenytoin, phenytoin, oral hypoglycemic agents, theophylline and other xanthine derivatives) – due to the inhibition of microsomal oxidation in hepatocytes by azithromycin).

Lincosamines weaken the effectiveness, tetracycline and chloramphenicol-increase. Pharmacologically incompatible with heparin.

How to take, course of administration and dosage

Inside,1 hour before or 2 hours after meals 1 time a day.

Adults with upper and lower respiratory tract infections – 0.5 g / day for 1 dose for 3 days (course dose-1.5 g). For infections of the skin and soft tissues – 1 g / day on the first day for 1 reception, then 0.5 g / day daily from day 2 to day 5 (the course dose is 3 g). Acute infections of the genitourinary organs (uncomplicated urethritis or cervicitis) – once 1 g.

In Lyme disease (borreliosis) for the treatment of stage I (erythema migrans) – 1 g on the first day and 0.5 g daily from day 2 to 5 (course dose – 3 g). In gastric and duodenal ulcers associated with Helicobacter pylori – 1 g / day for 3 days as part of combined anti-helicobacter therapy.

Children are prescribed at the rate of 10 mg / kg once a day for 3 days or on the first day – 10 mg / kg, then 4 days-5-10 mg / kg / day for 3 days (the course dose is 30 mg/kg).

In the treatment of erythema migrans in children, the dose is 20 mg / kg on the first day and 10 mg / kg from day 2 to day 5. IV, in the treatment of pneumonia-0.5 g once, for at least 2 days, then-inside,2 capsules (0.25 g each); the course is 7-10 days.

Overdose

Symptoms: severe nausea, temporary hearing loss, vomiting, diarrhea.

Special instructions

It is necessary to observe a break of 2 hours with simultaneous use of antacids.

After discontinuation of treatment, hypersensitivity reactions may persist in some patients, which requires specific therapy under the supervision of a doctor.

Composition

Capsule Form of production

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25°C. The drug should be stored out of the reach of children.

Active ingredient

Azithromycin

Conditions of release from pharmacies

By prescription

Dosage form

of the capsule

Description

Children over 12 years of age, Pregnant women as prescribed by a doctor, Children as prescribed by a doctor, Adults as prescribed by a doctor

Indications

Gastrointestinal infections caused by Helicobacter Pylori, Pharyngitis, Skin Infections, Respiratory Tract Infections, Pneumonia, Urethritis, Sinusitis, Tonsillitis, Infectious Diseases, Sore Throat, Otitis Media, Bronchitis

Weight

Weight: 9 gr.