Voltaren solution 25 mg/ml 3 ml ampoules 5 pcs, 5 pcs.

Composition

Active ingredient:

diclofenac (in the form of sodium salt) – 25 mg (1 ampoule-75 mg);

Auxiliary substances:

mannitol,

sodium disulfite,

benzyl alcohol,

propylene glycol,

d/i water,

sodium hydroxide.

Pharmacological action

Voltaren is a nonsteroidal anti-inflammatory drug (NSAID). It has a pronounced analgesic, anti-inflammatory and antipyretic effect.

The main mechanism of action of diclofenac, established in the experimental conditions, is considered to be inhibition of prostaglandin biosynthesis. Prostaglandins play an important role in the genesis of inflammation, pain, and fever.

In vitro, diclofenac sodium in concentrations equivalent to those achieved in the treatment of patients does not inhibit the biosynthesis of cartilage proteoglycans.

In rheumatic diseases, the anti-inflammatory and analgesic properties of Voltaren provide a clinical effect characterized by a significant reduction in the severity of such manifestations of diseases as pain at rest and during movement, morning stiffness and joint swelling, as well as an improvement in functional condition.

With post-traumatic and postoperative inflammatory phenomena, Voltaren quickly relieves pain (occurring both at rest and during movement), reduces inflammatory edema and swelling of the postoperative wound.

When using Voltaren in tablets and suppositories, a pronounced analgesic effect of the drug was noted in moderate and severe pain of non-rheumatic origin. Voltaren has also been shown to reduce pain and reduce blood loss in primary dysmenorrhea.

Indications

• elevated body temperature in various infectious and inflammatory diseases
• mild to moderate pain
• arthritis
• joint inflammation in gout.

Use during pregnancy and lactation

Voltaren should not be used during pregnancy, breast-feeding, children under 6 years of age and with a body weight of less than 7 kg.

Contraindications

• peptic ulcer of the stomach and duodenum
• bronchial asthma
• hypersensitivity to the drug Voltaren.

Side effects

From the digestive system:

Sometimes-epigastric pain, nausea, vomiting, diarrhea, abdominal cramps, dyspepsia, flatulence, Anorexia, increased activity of aminotransferases in the blood serum.

Rarely – gastrointestinal bleeding (vomiting of blood, melena, diarrhea mixed with blood), ulcers of the stomach and intestines, accompanied or not accompanied by bleeding or perforation, hepatitis, accompanied or not accompanied by jaundice.

In some cases – aphthous stomatitis, glossitis, damage to the esophagus, the occurrence of diaphragm-like strictures in the intestine, disorders of the distal colon, such as non-specific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn’s disease, constipation, pancreatitis, lightning hepatitis.

From the central nervous system and peripheral nervous system:

Sometimes-headache, Dizziness

Rarely-drowsiness.

In some cases – sensory disturbances, including Paresthesia, memory disorders, disorientation, Insomnia, irritability, convulsions, Depression, anxiety, nightmares, tremors, psychotic reactions, Aseptic meningitis.

From the side of the senses:

In some cases-visual disturbances (blurred vision, diplopia), hearing disorders, tinnitus, taste disorders.

From the cardiovascular system:

In some cases-palpitations, chest pain, increased blood pressure, worsening congestive heart failure.

Dermatological reactions:

Sometimes-skin rashes.

Rarely – urticaria.

In some cases – bullous rashes, eczema, erythema multiforme, Stevens-Johnson syndrome, Lyell’s syndrome (acute toxic epidermal necrolysis), erythroderma (exfoliative dermatitis), hair loss, photosensitivity reactions, purpura (including allergic).

From the urinary system:

Rarely-edema.

In some cases-acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.

From the hematopoietic system:

In some cases – thrombocytopenia, leukopenia, hemolytic anemia, aplastic anemia, agranulocytosis.

Hypersensitivity reactions:

Rarely-bronchospasm, systemic anaphylactic / anaphylactoid reactions, including hypotension.

In some cases-vasculitis, pneumonitis.

Local reactions:

Compaction, pain.

In some cases – abscesses, necrosis.

The listed side effects were observed, including when using doses of the drug and the duration of treatment that differ from the recommended ones.

Interaction

Voltaren may increase the concentration of lithium and digoxin in plasma when used concomitantly with these drugs.

Voltaren, like other NSAIDs, may reduce the effect of diuretics. Concomitant use of Voltaren with potassium-sparing diuretics may lead to an increase in blood potassium levels (in the case of such a combination of drugs, this indicator should be monitored frequently).

Concomitant use of Voltaren with other NSAIDs may increase the risk of side effects.

Although clinical studies have not established the effect of Voltaren on the action of anticoagulants, there are isolated reports of an increased risk of bleeding in cases of their combined use. Careful monitoring of patients receiving these medications at the same time is recommended.

Voltaren can be administered together with oral hypoglycemic drugs and the effectiveness of the latter does not change. However, there are separate reports of the development of both hypoglycemia and hyperglycemia in such cases, which made it necessary to change the dose of hypoglycemic drugs against the background of Voltaren use.

Caution should be exercised when using NSAIDs less than 24 hours before the start of use or after the end of methotrexate therapy, as its level in the blood (and, consequently, toxicity) may increase.

The effect of NSAIDs on the activity of prostaglandins in the kidneys may increase the nephrotoxicity of cyclosporine.

There have been isolated reports of seizures in patients taking concomitant NSAIDs and quinolone antibacterial drugs.

Do not mix the Voltaren solution contained in ampoules with solutions of other drugs for injection.

How to take, course of administration and dosage

Intramuscularly,75 mg of the drug is administered intramuscularly, then further treatment is carried out using tablets or suppositories.

For children over 6 years of age and adolescents, only tablets of the usual duration of action of 25 mg and, if necessary, a solution for injections are used.

The daily dose of Voltaren is 2 mg / kg of the child’s body weight.

Overdose

Symptoms: decreased blood pressure, renal failure, convulsions, gastrointestinal disorders and respiratory depression.

Treatment: supportive and symptomatic. It is unlikely that forced diuresis, hemodialysis or hemoperfusion will be useful for the elimination of NSAIDs, since the active substances of these drugs are largely bound to plasma proteins and undergo intensive metabolism.

Special instructions

Concomitant administration of Voltaren with other painkillers and anti-inflammatory drugs may increase the risk of side effects.

Simultaneous use of alcohol is not recommended.

Form of production

Solution for intramuscular administration.

Storage conditions

Store in a dark place at a temperature not exceeding 30°C.

Shelf

life is 2 years.

Active ingredient

Diclofenac

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults as directed by your doctor

Indications

Osteoarthritis, Gout, Periarthritis, Sciatica, Swelling after injuries and operations, Adnexitis, Bursitis, Osteoarthritis and Arthritis, Rheumatoid Arthritis, Migraine, Lumbago, Tendon Inflammation

Weight

Weight: 44 gr.