Snupoxy (Spray) Instructions for Use

Marketing Authorization Holder

Nizhpharm JSC (Russia)

ATC Code

R01AA05 (Oxymetazoline)

Active Substance

Oxymetazoline (Rec.INN registered by WHO)

Dosage Forms

	Snupoxy	Metered nasal spray 11.25 mcg/dose
		Metered nasal spray 22.5 mcg/dose

Dosage Form, Packaging, and Composition

Metered nasal spray

10 ml (164 doses) – bottles – cardboard packs – Over-the-Counter

Metered nasal spray

10 ml (164 doses) – bottles – cardboard packs – Over-the-Counter

Clinical-Pharmacological Group

Vasoconstrictor drug for topical use in ENT practice

Pharmacotherapeutic Group

Drugs for the treatment of nasal diseases; decongestants and other drugs for topical use; sympathomimetics

Pharmacological Action

Adrenomimetic agent for topical use. It has a vasoconstrictive effect. When applied intranasally, it reduces swelling of the mucous membrane of the upper respiratory tract.

Pharmacokinetics

When applied intranasally, T_1/2 is 35 hours.

Indications

Nasal congestion in colds, sinusitis, eustachitis, hay fever, allergic rhinitis.

To relieve swelling before diagnostic procedures in the nasal passages.

ICD codes

Dosage Regimen

Administer intranasally after clearing the nasal passages.

For adults and children aged 6 years and older, use one injection of the 11.25 mcg/dose or 22.5 mcg/dose strength into each nostril.

Apply the spray no more than two to three times per day as needed for congestion relief.

The maximum duration of continuous use is 3 to 5 days.

Do not exceed the recommended dosage or duration of treatment to avoid rebound congestion (medication-induced rhinitis).

For children under 6 years of age, use only as directed by a physician and with an appropriate pediatric dosage form.

Prior to first use, prime the pump by pressing the actuator several times until a fine spray is produced.

To administer, keep the head upright, insert the tip into the nostril, and spray while breathing in gently through the nose.

Adverse Reactions

Local reactions possibly – burning, dryness of the nasal mucosa, sneezing; rarely – after the effect of the application wears off, the development of a strong feeling of nasal congestion (reactive hyperemia).

Systemic reactions multiple overdoses with topical application may lead to tachycardia and increased blood pressure; very rarely – anxiety, insomnia, fatigue, headaches, nausea.

Contraindications

Atrophic rhinitis, angle-closure glaucoma, hypersensitivity to oxymetazoline.

With caution

Use of MAO inhibitors and the period up to 10 days after their administration; use of drugs that promote an increase in blood pressure and the period up to 10 days after their administration; increased intraocular pressure; severe forms of cardiovascular diseases (arterial hypertension, coronary artery disease), thyrotoxicosis, diabetes mellitus, pregnancy, breastfeeding period.

Use in Pregnancy and Lactation

Use with caution during pregnancy and lactation (breastfeeding).

Pediatric Use

Used in children according to indications in appropriate dosage forms.

Geriatric Use

Use with caution in elderly patients to avoid exacerbation of chronic diseases.

Special Precautions

Avoid prolonged use and overdose, especially in children.

Effect on the ability to drive vehicles and mechanisms

When used in doses exceeding the recommended ones, a general effect on the cardiovascular system and central nervous system cannot be excluded. In such cases, a decrease in the ability to drive vehicles and engage in other potentially hazardous activities is possible.

Drug Interactions

With simultaneous use of MAO inhibitors and tricyclic antidepressants, an increase in blood pressure is possible.

Oxymetazoline slows down the absorption of local anesthetics and prolongs their action.

Concomitant use of other vasoconstrictor drugs increases the risk of side effects.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.