Thiamine chloride-Echo (Capsules) Instructions for Use

Marketing Authorization Holder

NPC Ekho, CJS (Russia)

Contact Information

NPC Ekho, CJSC (Russia)

ATC Code

A11DA01 (Thiamine)

Active Substance

Thiamine (Rec.INN WHO registered)

Dosage Form

Thiamine chloride-Echo

Capsules 100 mg: 30 pcs.

Dosage Form, Packaging, and Composition

Capsules are hard gelatin, size №0, yellow in color; the capsule contents are a powder white or white with a creamy tint, with a characteristic odor.

Excipients: potato starch, refined sugar.

30 pcs. – polymer bottles.

Clinical-Pharmacological Group

B vitamin

Pharmacotherapeutic Group

Vitamin preparation

Pharmacological Action

Vitamin B.

Vitamin B₁ is a coenzyme of the most important enzymes – transaldolases and transketolases, which mainly catalyze carbohydrate metabolism processes, has a positive effect on the conduction of nerve impulses by influencing polarization in the area of neuromuscular synapses.

It plays an important role in carbohydrate, protein, and fat metabolism, and protects cell membranes from the toxic effects of lipid peroxidation products.

Pharmacokinetics

Absorption

Absorption is high, throughout the entire small intestine. Before absorption, thiamine chloride is released from its bound state by digestive enzymes. The concentration of thiamine chloride in the blood is relatively low.

Distribution

Free thiamine is predominantly found in the plasma, while its phosphate esters are found in erythrocytes and leukocytes. Half of the total amount is contained in striated muscles (including the myocardium) and about 40% is in the internal organs.

Metabolism

Phosphorylation occurs in the liver. The most active phosphate ester is thiamine diphosphate, which has coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, and spleen.

Excretion

It is excreted through the intestines and kidneys.

Indications

• Monotherapy for the treatment of hypovitaminosis and avitaminosis B₁;
• As part of complex therapy for polyneuritis, dystrophic myocardial lesions, chronic liver lesions, Wernicke’s encephalopathy (Korsakoff’s psychosis);
• As part of complex therapy for alcohol and opioid dependence.

ICD codes

Dosage Regimen

Take the drug orally.

For the treatment of mild to moderate thiamine deficiency, administer one 100 mg capsule once daily.

For severe deficiency states, including Wernicke’s encephalopathy, the dosage is one 100 mg capsule two to three times daily.

In cases of alcoholic polyneuropathy and dystrophic myocardial lesions, use one capsule once daily for a duration of two to three weeks.

For the management of alcohol or opioid dependence, prescribe one capsule two to three times daily for three to four weeks.

Adjust the duration of therapy based on clinical response and the underlying condition being treated.

Do not exceed the recommended daily dosage without medical supervision.

Swallow the capsule whole with a sufficient amount of water; do not chew or crush.

Adverse Reactions

Allergic reactions rarely – skin itching, urticaria, angioedema.

Contraindications

• Hypersensitivity to the components of the drug.

Use in Pregnancy and Lactation

Data on the use of the drug during pregnancy and lactation are not provided.

Special Precautions

No special instructions for the drug are provided.

Overdose

Data on drug overdose are not provided.

Drug Interactions

Data on drug interactions are not provided.

Storage Conditions

The drug should be stored out of the reach of children, in a dry, light-protected place at a temperature from 18°C (64.4°F) to 20°C (68°F).

Shelf Life

Shelf life – 3 years.

Dispensing Status

The drug is approved for use as an over-the-counter product.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.