Troxerutin (Capsules, Gel) Instructions for Use

Instructions
Dosage forms

ATC Code

C05CA04 (Troxerutin)

Active Substance

Troxerutin (Rec.INN registered by WHO)

Clinical-Pharmacological Group

Drug used for disorders of venous circulation. Angioprotector

Pharmacotherapeutic Group

Angioprotectors; capillary stabilizing agents; bioflavonoids

Pharmacological Action

A treatment for chronic venous insufficiency, a semi-synthetic bioflavonoid (a derivative of rutin) of the benzopyran class, possesses P-vitamin activity, and has a venotonic, angioprotective, anti-inflammatory, and anti-edematous effect, reducing capillary permeability and fragility.

Its pharmacodynamic properties are associated with the participation of the bioflavonoids of troxerutin in redox processes and the inhibition of hyaluronidase. By suppressing hyaluronidase, Troxerutin stabilizes hyaluronic acid in cell membranes, reducing their permeability. It possesses antioxidant activity, thereby preventing the oxidation of ascorbic acid, adrenaline, and lipids. Furthermore, it reduces capillary permeability and fragility, preventing damage to the basement membrane of endothelial cells when exposed to various factors. Troxerutin increases the density of the vascular wall, reduces the exudation of the liquid part of plasma and the diapedesis of blood cells. It reduces exudative inflammation in the vascular wall by decreasing platelet adhesion to its surface. It inhibits aggregation and increases the degree of erythrocyte deformation.

The use of troxerutin is possible both in the initial and late stages of treatment for chronic venous insufficiency, and it can be used as one of the components of complex therapy. Troxerutin reduces swelling and the feeling of heaviness in the legs, decreases the intensity of pain and cramps, and improves tissue trophism.

Troxerutin alleviates symptoms associated with hemorrhoids (pain, exudation, itching, bleeding).

Due to its effect on the permeability and resistance of capillary walls, Troxerutin helps slow the progression of diabetic retinopathy.

The influence of troxerutin on the rheological properties of blood contributes to the prevention of the development of microthrombosis of retinal vessels.

Pharmacokinetics

Troxerutin is rapidly absorbed when the drug is taken orally. The C_max of troxerutin in blood plasma is reached on average 1.75±0.46 hours after oral administration. Absorption is approximately 10-15%. Bioavailability increases with increasing dose. T_1/2 is 6.77±2.37 hours. The therapeutic concentration of the drug in blood plasma is maintained for 8 hours. A second peak in the plasma concentration of the drug is observed 30 hours after troxerutin administration, due to enterohepatic recirculation. It is partially metabolized in the liver to form glucuronide and trihydroxyethylquercetin. It is excreted mainly through the intestines (up to 65-70%), a smaller part (up to 25%) of the drug is excreted unchanged by the kidneys.

Indications

As part of complex therapy for the following diseases: chronic venous insufficiency; trophic disorders in chronic venous insufficiency and trophic ulcers; varicose veins; superficial thrombophlebitis, periphlebitis; post-thrombotic syndrome; post-traumatic edema and hematomas of soft tissues; as an auxiliary treatment after sclerotherapy and/or removal of varicose veins of the lower extremities; hemorrhoids (to alleviate symptoms); diabetic angiopathy, retinopathy.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
H36.0	Diabetic retinopathy
I79.2	Peripheral angiopathy in diseases classified elsewhere (including diabetic angiopathy)
I80.0	Phlebitis and thrombophlebitis of superficial vessels of lower extremities
I83	Varicose veins of lower extremities
I83.2	Varicose veins of lower extremities with ulcer and inflammation
I87.0	Postthrombotic syndrome
I87.2	Venous insufficiency (chronic) (peripheral)
K64	Hemorrhoids and perianal venous thrombosis
L98.4	Chronic skin ulcer, not elsewhere classified
T14.0	Superficial injury of unspecified body region (including abrasion, bruise, contusion, hematoma, bite of nonvenomous insect)
T14.3	Dislocation, sprain and strain of joint and ligament of unspecified body region

ICD-11 code	Indication
9B71.0Z	Diabetic retinopathy, unspecified
BD53.Y	Other specified secondary involvement of arteries and arterioles
BD70.0	Superficial thrombophlebitis of lower extremities
BD74.1Z	Varicose veins of lower extremities, unspecified
BD74.Z	Chronic venous insufficiency of lower extremities, unspecified
DB6Z	Hemorrhoids or perianal venous diseases, unspecified
EA40	Tropical phagedenic ulcer
EF60	Ischemic ulceration of the skin
EH92	Dermatoses provoked by friction or mechanical impact
EH92.1	Blister due to friction
EM0Z	Unspecified skin disorder
ME60.2	Ulcerative skin lesion of unspecified nature
ND56.0	Superficial injury of unspecified body region
ND56.3	Dislocation, sprain or strain of unspecified body region

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Gel

For external use: apply the gel in a thin, even layer in the morning and evening to the skin over the affected area and massage gently until completely absorbed. The dose of the drug depends on the area of the damaged surface but should not exceed 3-4 cm of gel (1.5-2 g). The gel can be applied under an occlusive dressing.

Capsules

For oral administration, the daily dose is 600-900 mg for 2-4 weeks.

Adverse Reactions

From the immune system hypersensitivity reactions.

From the nervous system headache.

From the vascular system flushing.

From the digestive system nausea, vomiting, stomach pain, flatulence, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract.

From the skin and subcutaneous tissues erythema, skin itching, skin rash.

Contraindications

Hypersensitivity to troxerutin; peptic ulcer of the stomach, duodenum, chronic gastritis in the acute phase; first trimester of pregnancy; breastfeeding period; children under 18 years of age.

With caution

In patients with chronic renal failure (with long-term use).

Use in Pregnancy and Lactation

Use in the first trimester of pregnancy is contraindicated. The possibility of use in the second and third trimesters of pregnancy is determined by the doctor and is only possible if the intended benefit to the mother outweighs the potential risk to the fetus.

Data on the penetration of troxerutin into breast milk are not available. Use during breastfeeding is contraindicated.

Use in Renal Impairment

In patients with chronic renal failure (with long-term use).

Pediatric Use

The drug is contraindicated for use in children and adolescents under 18 years of age.

Geriatric Use

The drug is approved for use in elderly patients.

Special Precautions

When treating superficial thrombophlebitis or deep vein thrombosis, the use of troxerutin does not exclude the need for anti-inflammatory and antithrombotic therapy.

Troxerutin is not effective for edema caused by concomitant diseases of the liver, kidneys, and heart.

Drug Interactions

With simultaneous use, it enhances the effect of ascorbic acid on the resistance and permeability of the vascular wall.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Troxerutin [Atoll LLC (Russia)]
Gel for external use 2%: tube 20 g, 30 g, 40 g, 50 g, or 100 g

Marketing Authorization Holder

Atoll LLC (Russia)

Manufactured By

Ozon, LLC (Russia)

Dosage Form

Troxerutin

Gel for external use 2%: tube 20 g, 30 g, 40 g, 50 g, or 100 g

Dosage Form, Packaging, and Composition

Gel for external use	1 g
Troxerutin	20 mg

20 g – aluminum tubes (1) – cardboard packs.
30 g – aluminum tubes (1) – cardboard packs.
40 g – aluminum tubes (1) – cardboard packs.
50 g – aluminum tubes (1) – cardboard packs.
100 g – aluminum tubes (1) – cardboard packs.

Troxerutin [Atoll LLC (Russia)]
Capsules 300 mg: 10, 20, 30, 50, 60, 90, 100, 150, 180 or 300 pcs.

Marketing Authorization Holder

Atoll LLC (Russia)

Manufactured By

Ozon, LLC (Russia)

Dosage Form

Troxerutin

Capsules 300 mg: 10, 20, 30, 50, 60, 90, 100, 150, 180 or 300 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin size 0, light yellow body, light purple cap, opaque. The capsule contents are from yellow to yellow-green or yellow-brown in the form of a powder with particles of various sizes and granules or a powder compressed into cylinders that disintegrate when pressed.

	1 caps.
Troxerutin	300 mg

Excipients : lactose monohydrate (milk sugar) – 39.5 mg, sodium carboxymethyl starch – 7 mg, magnesium stearate – 3.5 mg.

Capsule body composition iron oxide red dye – 0.0071%, iron oxide yellow dye – 0.1227%, titanium dioxide – 2%, gelatin – up to 100%.

Capsule cap composition brilliant blue dye – 0.019%, allura red dye – 0.045%, titanium dioxide – 3%, gelatin – up to 100%.

10 pcs. – contour cell packs (1) – cardboard packs.
10 pcs. – contour cell packs (2) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
10 pcs. – contour cell packs (10) – cardboard packs.
30 pcs. – contour cell packs (1) – cardboard packs.
30 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (3) – cardboard packs.
30 pcs. – contour cell packs (5) – cardboard packs.
30 pcs. – contour cell packs (6) – cardboard packs.
30 pcs. – contour cell packs (10) – cardboard packs.
10 pcs. – jars (1) with first-opening control – cardboard packs.
20 pcs. – jars (1) with first-opening control – cardboard packs.
30 pcs. – jars (1) with first-opening control – cardboard packs.
50 pcs. – jars (1) with first-opening control – cardboard packs.
60 pcs. – jars (1) with first-opening control – cardboard packs.
100 pcs. – jars (1) with first-opening control – cardboard packs.

Troxerutin [Biokhimik, JSC (Russia)]
Capsules 300 mg: 30 or 50 pcs.

Marketing Authorization Holder

Biokhimik, JSC (Russia)

Dosage Form

Troxerutin

Capsules 300 mg: 30 or 50 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin, size 0, yellow body, yellow cap, cylindrical in shape with hemispherical ends; capsule contents – granules or powder from yellow to greenish-yellow; compaction of the capsule contents into a cylindrical shape is allowed.

	1 caps.
Troxerutin	300 mg

Excipients : lactose monohydrate – 22 mg, macrogol (polyethylene glycol) – 21 mg, colloidal silicon dioxide – 4 mg, magnesium stearate – 3 mg.

Capsule body composition: titanium dioxide (E171) – 1%, iron oxide yellow dye (E172) – 0.5%, gelatin – up to 100%.
Capsule cap composition: titanium dioxide (E171) – 1%, iron oxide yellow dye (E172) – 0.5%, gelatin – up to 100%.
Or
Capsule body composition: titanium dioxide (E171) – 2%, iron oxide yellow dye (E172) – 0.629%, gelatin – up to 100%.
Capsule cap composition: titanium dioxide (E171) – 2%, iron oxide yellow dye (E172) – 0.629%, gelatin – up to 100%.

10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.

Troxerutin [Vifitech, CJSC (Russia)]
Capsules 300 mg: 30, 60, or 90 pcs.

Marketing Authorization Holder

Vifitech, CJSC (Russia)

Dosage Form

Troxerutin

Capsules 300 mg: 30, 60, or 90 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin size 1, yellow; capsule contents – a mixture of granules and powder or a compacted mass from light yellow with a grayish, greenish, or brownish tint.

	1 caps.
Troxerutin	300 mg

Excipients : macrogol 6000 – 12 mg, magnesium stearate – 3.12 mg.

Hard gelatin capsules size 1:
Body sunset yellow dye – 0.002%, quinoline yellow dye – 0.25%, titanium dioxide – 0.99%, gelatin – up to 100%.
cap sunset yellow dye – 0.002%, quinoline yellow dye – 0.25%, titanium dioxide – 0.99%, gelatin – up to 100%.

10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
10 pcs. – contour cell packs (9) – cardboard packs.

Troxerutin [Dominanta-Service, JSC (Russia)]
Gel for external use 2%: tube 30 g, 40 g, or 50 g

Marketing Authorization Holder

Dominanta-Service, JSC (Russia)

Manufactured By

Vetprom, AD (Bulgaria)

Dosage Form

Troxerutin

Gel for external use 2%: tube 30 g, 40 g, or 50 g

Dosage Form, Packaging, and Composition

Gel for external use from yellow to yellow-green, homogeneous, transparent.

	100 g
Troxerutin	2 g

Excipients : carbomer (carbopol 940) – 0.6 g, trolamine – 0.7 g, disodium edetate – 0.05 g, benzalkonium chloride, 50% solution – 0.2 g, purified water – 96.45 g.

30 g – tubes (1) – cardboard packs.
40 g – tubes (1) – cardboard packs.
50 g – tubes (1) – cardboard packs.

Troxerutin [Zelenaya Dubrava, CJSC (Russia)]
Gel for external use 2%: tubes 30 g, 40 g, or 50 g

Marketing Authorization Holder

Zelenaya Dubrava, CJSC (Russia)

Dosage Form

Troxerutin

Gel for external use 2%: tubes 30 g, 40 g, or 50 g

Dosage Form, Packaging, and Composition

Gel for external use homogeneous, transparent, from yellow to light brown or yellow-green.

	100 g
Troxerutin	2 g

Excipients : carbomer – 0.6 g, sodium hydroxide – 0.132 g, benzalkonium chloride – 0.0575 g, disodium edetate dihydrate – 0.05 g, purified water – up to 100 g.

30 g – aluminum tubes (1) – cardboard packs.
40 g – aluminum tubes (1) – cardboard packs.
50 g – aluminum tubes (1) – cardboard packs.

Troxerutin [Pranapharm, LLC (Russia)]
Capsules 300 mg: 10, 20, 30, 40 or 50 pcs.

Marketing Authorization Holder

Pranapharm, LLC (Russia)

Dosage Form

Troxerutin

Capsules 300 mg: 10, 20, 30, 40 or 50 pcs.

Dosage Form, Packaging, and Composition

Capsules hard, gelatin, size No. 0, white; the contents are a granulated powder or a mixture of powder and granules, or a compressed mass taking the shape of the capsule, greenish-yellow in color.

	1 caps.
Troxerutin	300 mg

Excipients: macrogol 6000, colloidal silicon dioxide, magnesium stearate, lactose monohydrate – to obtain capsule contents weighing 335 mg.

Excipients of the capsule shell: titanium dioxide, gelatin.

Troxerutin [Promomed Rus LLC (Russia)]
Gel for external use 2%: tube 25 g 1 pc., jars 25 g 1 or 20 pcs.

Marketing Authorization Holder

Promomed Rus LLC (Russia)

Dosage Form

Troxerutin

Gel for external use 2%: tube 25 g 1 pc., jars 25 g 1 or 20 pcs.

Dosage Form, Packaging, and Composition

Gel for external use	100 g
Troxerutin	2 g

Excipients: carbomer 940 0.6 g, disodium edetate 0.05 g, benzalkonium chloride 0.1 g, sodium hydroxide solution 30% 0.7 g, purified water 96.55 g.

25 g – aluminum tubes (1) – cardboard packs.
25 g – orange glass jars (1) – cardboard packs.
25 g – orange glass jars (20) – cardboard boxes.

Troxerutin [Sintez PJSC (Russia)]
Capsules 300 mg: 30, 50, 60, 90, or 100 pcs.

Marketing Authorization Holder

Sintez PJSC (Russia)

Dosage Form

Troxerutin

Capsules 300 mg: 30, 50, 60, 90, or 100 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin No. 0, yellow; the capsule contents are from greenish-yellow to yellow-green or yellow-brown in the form of a powder with various particle sizes and granules or powder compressed into cylinders that disintegrate upon pressure.

	1 caps.
Troxerutin	300 mg

Excipients: calcium stearate – 3.7 mg, talc – 9.25 mg, povidone (Kollidon 90F, Plasdone K 90) – 3.7 mg, sodium starch glycolate – 9.25 mg, microcrystalline cellulose – 44.1 mg.

Composition of the gelatin capsule: yellow iron oxide – 0.629%, titanium dioxide – 2%, gelatin – up to 100%.

10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
15 pcs. – contour cell packs (2) – cardboard packs.
15 pcs. – contour cell packs (4) – cardboard packs.
15 pcs. – contour cell packs (6) – cardboard packs.
20 pcs. – contour cell packs (3) – cardboard packs.
20 pcs. – contour cell packs (5) – cardboard packs.
30 pcs. – polymer jars (1) – cardboard packs.
50 pcs. – polymer jars (1) – cardboard packs.
60 pcs. – polymer jars (1) – cardboard packs.
90 pcs. – polymer jars (1) – cardboard packs.
100 pcs. – polymer jars (1) – cardboard packs.

Troxerutin [Stmfarm LLC (Russia)]
Gel for external use 2%: tubes 40 g

Marketing Authorization Holder

Stmfarm LLC (Russia)

Manufactured By

Zelenaya Dubrava, CJSC (Russia)

Dosage Form

Troxerutin

Gel for external use 2%: tubes 40 g

Dosage Form, Packaging, and Composition

Gel for external use homogeneous, transparent, from yellow to light brown or yellow-green in color.

	100 g
Troxerutin	2 g

Excipients: carbomer – 0.6 g, sodium hydroxide – 0.132 g, benzalkonium chloride – 0.0575 g, disodium edetate – 0.05 g, purified water – up to 100 g.

40 g – aluminum tubes (1) – cardboard packs.

Troxerutin [Tula Pharmaceutical Factory, LLC (Russia)]
Gel for external use 2%: jars or tubes 20 g, 25 g, 30 g, 40 g, 50 g, 60 g, 70 g, 80 g, or 100 g

Marketing Authorization Holder

Tula Pharmaceutical Factory, LLC (Russia)

Dosage Form

Troxerutin

Gel for external use 2%: jars or tubes 20 g, 25 g, 30 g, 40 g, 50 g, 60 g, 70 g, 80 g, or 100 g

Dosage Form, Packaging, and Composition

Gel for external use from yellow to light brown or yellow-green in color, transparent, homogeneous.

	100 g
Troxerutin (calculated as 100% substance)	2 g

Excipients: carbomer 940 – 0.6 g, disodium edetate – 0.05 g, benzalkonium chloride – 0.0575 g, sodium hydroxide 30% – 0.7 g, purified water – up to 100 g.

20 g – jars (1) – cardboard packs.
25 g – jars (1) – cardboard packs.
30 g – jars (1) – cardboard packs.
40 g – jars (1) – cardboard packs.
50 g – jars (1) – cardboard packs.
60 g – jars (1) – cardboard packs.
70 g – jars (1) – cardboard packs.
80 g – jars (1) – cardboard packs.
100 g – jars (1) – cardboard packs.
20 g – tubes (1) – cardboard packs.
25 g – tubes (1) – cardboard packs.
30 g – tubes (1) – cardboard packs.
40 g – tubes (1) – cardboard packs.
50 g – tubes (1) – cardboard packs.
60 g – tubes (1) – cardboard packs.
70 g – tubes (1) – cardboard packs.
80 g – tubes (1) – cardboard packs.
100 g – tubes (1) – cardboard packs.

Troxerutin [Formula-FR, LLC (Russia)]
Gel for external use 2%: tubes or jars 20, 25, 30, 40, 50, 60, 70, 80, or 100 g

Marketing Authorization Holder

Formula-FR, LLC (Russia)

Manufactured By

Tula Pharmaceutical Factory, LLC (Russia)

Dosage Form

Troxerutin

Gel for external use 2%: tubes or jars 20, 25, 30, 40, 50, 60, 70, 80, or 100 g

Dosage Form, Packaging, and Composition

Gel for external use homogeneous, transparent, yellow or greenish-yellow in color.

	100 g
Troxerutin (calculated as 100% substance)	2 g

Excipients: carbomer 940 – 0.6 g, disodium edetate dihydrate – 0.05 g, benzalkonium chloride – 0.0575 g, sodium hydroxide solution 30% – 0.7 g, purified water – up to 100 g.

20 g – aluminum tubes (1) – cardboard packs.
20 g – jars (1) – cardboard packs (complete with lids or closure means).
25 g – aluminum tubes (1) – cardboard packs.
25 g – jars (1) – cardboard packs (complete with lids or closure means).
30 g – aluminum tubes (1) – cardboard packs.
30 g – jars (1) – cardboard packs (complete with lids or closure means).
40 g – aluminum tubes (1) – cardboard packs.
40 g – jars (1) – cardboard packs (complete with lids or closure means).
50 g – aluminum tubes (1) – cardboard packs.
50 g – jars (1) – cardboard packs (complete with lids or closure means).
60 g – aluminum tubes (1) – cardboard packs.
60 g – jars (1) – cardboard packs (complete with lids or closure means).
70 g – aluminum tubes (1) – cardboard packs.
70 g – jars (1) – cardboard packs (complete with lids or closure means).
80 g – aluminum tubes (1) – cardboard packs.
80 g – jars (1) – cardboard packs (complete with lids or closure means).
100 g – aluminum tubes (1) – cardboard packs.
100 g – jars (1) – cardboard packs (complete with lids or closure means).

Troxerutin [Elius, LLC (Russia)]
Gel for external use 2%: tubes 50 g or 100 g

Marketing Authorization Holder

Elius, LLC (Russia)

Manufactured By

Vertex, JSC (Russia)

Dosage Form

Troxerutin

Gel for external use 2%: tubes 50 g or 100 g

Dosage Form, Packaging, and Composition

Gel for external use from yellow or greenish-yellow to light brown in color, homogeneous, transparent.

	1 g
Troxerutin	20 mg

Excipients: trolamine (triethanolamine) – 7 mg, carbomer – 6 mg, benzalkonium chloride solution 50% – 1 mg (calculated as 100% substance), disodium edetate – 0.5 mg, purified water – up to 1 g.

50 g – aluminum tubes (1) – cardboard packs.
100 g – aluminum tubes (1) – cardboard packs.

Troxerutin Velpharm [Velpharm, LLC (Russia)]
Capsules 300 mg: 10, 20, 30, 40, 50 or 60 pcs.

Marketing Authorization Holder

Velpharm, LLC (Russia)

Dosage Form

Troxerutin Velpharm

Capsules 300 mg: 10, 20, 30, 40, 50 or 60 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin, No. 1, with a white body and a yellow cap; the capsule contents are from greenish-yellow or yellow to yellow-green or yellow-brown in the form of a powder with various particle sizes and granules or powder compressed into cylinders that disintegrate upon pressure.

	1 caps.
Troxerutin	300 mg

Excipients: macrogol 6000 (polyethylene glycol 6000, polyethylene oxide 6000), magnesium stearate.

Composition of the gelatin capsule body titanium dioxide, gelatin.
Composition of the gelatin capsule cap sunset yellow FCF, quinoline yellow, titanium dioxide, gelatin.

Troxerutin Vertex [Vertex, JSC (Russia)]
Capsules 300 mg: 30, 50, 60, 90, or 100 pcs.

Marketing Authorization Holder

Vertex, JSC (Russia)

Dosage Form

Troxerutin Vertex

Capsules 300 mg: 30, 50, 60, 90, or 100 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin No. 0, yellow, the capsule contents are a mixture of granules and powder or a compacted mass from yellow to greenish-yellow or brownish-yellow in color.

	1 caps.
Troxerutin	300 mg

Excipients: lactose monohydrate – 39 mg, talc – 10.8 mg, colloidal silicon dioxide – 7.2 mg, magnesium stearate – 3 mg.

Composition of the gelatin capsule: titanium dioxide – 2%, yellow iron oxide (iron oxide) – 0.6286%, gelatin – up to 100%.

6 pcs. – contour cell packs (5) – cardboard packs.
10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (5) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
15 pcs. – contour cell packs (6) – cardboard packs.
20 pcs. – contour cell packs (3) – cardboard packs.
20 pcs. – contour cell packs (5) – cardboard packs.
50 pcs. – jars (1) – cardboard packs.

Troxerutin Vramed [Sopharma, JSC (Bulgaria)]
Capsules 300 mg: 30, 50, or 100 pcs.

Marketing Authorization Holder

Sopharma, JSC (Bulgaria)

Dosage Form

Troxerutin Vramed

Capsules 300 mg: 30, 50, or 100 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin, No. 1, yellow; the capsule contents are granules or a compressed mass taking the shape of the capsule, from light yellow to dark yellow in color.

	1 caps.
Troxerutin	300 mg

Excipients: lactose monohydrate – 5 mg, colloidal silicon dioxide – 8 mg, macrogol 6000 – 15 mg, magnesium stearate – 7 mg.

Composition of the capsule shell titanium dioxide – 2%, quinoline yellow – 0.75%, sunset yellow FCF – 0.0059%, gelatin – up to 100%.

10 pcs. – blisters (3) – cardboard packs.
10 pcs. – blisters (5) – cardboard packs.
10 pcs. – blisters (10) – cardboard packs.

Troxerutin-AKOS [Sintez PJSC (Russia)]
Capsules 300 mg: 30, 50, 60, 90, or 100 pcs.

Marketing Authorization Holder

Sintez PJSC (Russia)

Dosage Form

Troxerutin-AKOS

Capsules 300 mg: 30, 50, 60, 90, or 100 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin No. 0 yellow; the capsule contents are from greenish-yellow or yellow to yellow-green or yellow-brown in color, in the form of a powder with various particle sizes and granules or powder compressed into cylinders that disintegrate upon pressure.

	1 caps.
Troxerutin	300 mg

Excipients: calcium stearate, talc, povidone (grade 90), sodium starch glycolate (sodium starch glycolate (type A), Primojel), microcrystalline cellulose M102.

Composition of gelatin capsule No. 0: yellow iron oxide, titanium dioxide, gelatin.

Troxerutin-BV [Bright Way, LLC (Russia)]
Capsules 300 mg: 10, 15, 20, 30, 40, 45, 50, 60, 75, 80, 90, 100, or 120 pcs.

Marketing Authorization Holder

Bright Way, LLC (Russia)

Manufactured By

Velpharm, LLC (Russia)

Dosage Form

Troxerutin-BV

Capsules 300 mg: 10, 15, 20, 30, 40, 45, 50, 60, 75, 80, 90, 100, or 120 pcs.

Dosage Form, Packaging, and Composition

Capsules hard gelatin size №1, with a white body and a yellow cap; the capsule contents are a powder ranging from greenish-yellow or yellow to yellow-green or yellow-brown in color, the presence of conglomerates or powder compressed into cylinders that disintegrate upon pressure is allowed.

	1 caps.
Troxerutin	300 mg

Excipients: macrogol 6000 (polyethylene glycol 6000, polyethylene oxide 6000), magnesium stearate.

Composition of the gelatin capsule: body: titanium dioxide, gelatin; cap: dye sunset yellow, dye quinoline yellow, titanium dioxide, gelatin.

10 pcs. – jars – cardboard packs.
10 pcs. – contour cell blisters – cardboard packs.
10 pcs. – contour cell blisters (2) – cardboard packs.
10 pcs. – contour cell blisters (3) – cardboard packs.
10 pcs. – contour cell blisters (4) – cardboard packs.
10 pcs. – contour cell blisters (5) – cardboard packs.
10 pcs. – contour cell blisters (6) – cardboard packs.
15 pcs. – contour cell blisters – cardboard packs.
15 pcs. – contour cell blisters (2) – cardboard packs.
15 pcs. – contour cell blisters (3) – cardboard packs.
15 pcs. – contour cell blisters (4) – cardboard packs.
15 pcs. – contour cell blisters (5) – cardboard packs.
15 pcs. – contour cell blisters (6) – cardboard packs.
20 pcs. – jars – cardboard packs.
20 pcs. – contour cell blisters – cardboard packs.
20 pcs. – contour cell blisters (2) – cardboard packs.
20 pcs. – contour cell blisters (3) – cardboard packs.
20 pcs. – contour cell blisters (4) – cardboard packs.
20 pcs. – contour cell blisters (5) – cardboard packs.
20 pcs. – contour cell blisters (6) – cardboard packs.
30 pcs. – jars – cardboard packs.
40 pcs. – jars – cardboard packs.
50 pcs. – jars – cardboard packs.
60 pcs. – jars – cardboard packs.
70 pcs. – jars – cardboard packs.
80 pcs. – jars – cardboard packs.
90 pcs. – jars – cardboard packs.