Vectrum^® Calcium (Tablets) Instructions for Use

Marketing Authorization Holder

Akrikhin Chemical and Pharmaceutical Plant, JSC (Russia)

ATC Code

A12AX (Calcium preparations in combination with vitamin D and/or other drugs)

Dosage Form

Vectrum® Calcium

Chewable tablets: 30 pcs.

Dosage Form, Packaging, and Composition

Chewable tablets are flat-cylindrical, with a bevel, from white to white with a yellowish or creamy tint with the presence of gray inclusions, with a characteristic fruity odor.

Excipients: lactose, sorbitol, aspartame, powdered flavoring with fruity odor, magnesium stearate, anhydrous citric acid.

10 pcs. – blister packs (3) – cardboard packs.

Clinical-Pharmacological Group

Drug regulating calcium and phosphorus metabolism

Pharmacotherapeutic Group

Multivitamin agent + multimineral

Pharmacological Action

Combined multivitamin preparation that regulates the metabolism of calcium and phosphorus in the body. It replenishes the deficiency of calcium and vitamin D₃ in the body.

Calcium is involved in the formation of bone tissue, mineralization of teeth, blood clotting, regulation of nerve conduction and muscle contractions, and in maintaining stable cardiac activity.

Colecalciferol (vitamin D₃) regulates the metabolism of calcium and phosphorus in the body and promotes the complete absorption of calcium.

Pharmacokinetics

Data on the pharmacokinetics of Vectrum Calcium are not provided.

Indications

Treatment and prevention of conditions accompanied by a deficiency of calcium and vitamin D₃ in the body

• Prevention and complex therapy of osteoporosis and its complications (bone fractures);
• Replenishment of calcium and vitamin D₃ deficiency in the elderly.

ICD codes

Dosage Regimen

For prophylactic use in adults, administer 1 tablet once daily.

Chew the tablet thoroughly before swallowing.

For the treatment of osteoporosis, the dosing regimen and duration of therapy are set individually by a physician.

Adjust the dose or temporarily discontinue use if serum calcium or creatinine levels increase.

Consider dietary intake and other sources of vitamin D₃ to avoid overdose.

Do not use concurrently with other vitamin-mineral complexes containing Calcium and vitamin D₃.

Be aware that acidic foods may increase, and weakly alkaline foods may decrease, calcium absorption.

With long-term use, monitor calcium levels in urine and calcium and creatinine in blood serum.

Adverse Reactions

From the digestive system: constipation, diarrhea, flatulence, nausea, abdominal pain.

From the metabolism: with long-term use – hypercalcemia, hypercalciuria.

Other: allergic reactions.

Contraindications

• Hypercalcemia;
• Hypercalciuria;
• Nephrolithiasis (formation of calcium stones);
• Renal failure;
• Osteoporosis due to prolonged immobilization;
• Phenylketonuria;
• Hypervitaminosis D₃;
• Children and adolescents under 18 years of age;
• Hypersensitivity to the drug components.

Use in Pregnancy and Lactation

Adequate and strictly controlled studies on the safety of Vectrum Calcium use during pregnancy and lactation have not been conducted.

Use in Renal Impairment

Contraindicated in renal failure.

Pediatric Use

The drug is contraindicated in children and adolescents under 18 years of age.

Special Precautions

If the concentration of calcium and creatinine in the blood serum increases, the dose should be reduced or the drug should be temporarily discontinued.

To avoid overdose, additional intake of vitamin D₃ from other sources should be taken into account. It is not recommended to use simultaneously with vitamin-mineral complexes containing Calcium and vitamin D₃.

When taking the drug, it should be taken into account that the acidic reaction of food products increases, and the weakly alkaline reaction decreases the absorption of calcium.

Control of laboratory parameters

With long-term use of Vectrum Calcium, control of calcium content in urine, calcium and creatinine in blood serum is necessary.

Overdose

Symptoms: nausea, vomiting, polyuria, constipation, pain in the epigastric region, hypercalcemia, hypercalciuria.

Treatment: gastric lavage; if necessary, symptomatic therapy is carried out.

Drug Interactions

The activity of vitamin D₃ may decrease when used simultaneously with phenytoin and barbiturates.

Simultaneous use of Vectrum Calcium and cardiac glycosides enhances the effect of the latter (monitoring of ECG and clinical condition of the patient is necessary).

When prescribing Vectrum Calcium and antibiotics from the tetracycline group simultaneously, the interval between taking the drugs should be at least 3 hours, because Calcium and vitamin D₃ increase the absorption of tetracyclines from the gastrointestinal tract.

Corticosteroids reduce the absorption of calcium.

Concomitant use of Vectrum Calcium and thiazide-like diuretics increases the risk of hypercalcemia by enhancing the reabsorption of calcium from the lumen of the renal tubules. Furosemide and other “loop” diuretics, on the contrary, increase the excretion of calcium by the kidneys.

Storage Conditions

The drug should be stored in a dry, light-protected place at a temperature not exceeding 25°C (77°F).

Shelf Life

Shelf life – 2 years.

Pharmacy supply conditions

The drug is approved for use as an over-the-counter product.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.