Acyzol (Capsules, Solution) Instructions for Use

ATC Code

V03AB (Antidotes)

Active Substance

Zinc bisvinylimidazole diacetate (Grouping name)

Clinical-Pharmacological Group

Antidote

Pharmacotherapeutic Group

Antidote

Pharmacological Action

Acyzol is a highly effective antidote against acute poisoning with lethal doses of carbon monoxide, as well as an effective antihypoxant in oxygen deficiency.

The administration of Acyzol to victims in mass casualty areas increases their chances of survival in severe forms of intoxication, accelerates the elimination of carbon monoxide, and contributes to the success of subsequent medical measures.

Acyzol is an original domestic drug that has no analogues abroad in terms of structure and action. There have been no medicinal or prophylactic agents used for carbon monoxide poisoning until now.

The use of Acyzol opens a fundamentally new way to combat anoxia by changing the affinity of hemoglobin for blood gases and increasing tolerance to high concentrations of carboxyhemoglobin.

Acyzol prevents the formation of carboxyhemoglobin by influencing the cooperative interaction of hemoglobin subunits, resulting in a decrease in the relative affinity of hemoglobin for carbon monoxide and an improvement in the oxygen-binding and gas-transport properties of blood.

Acyzol reduces the severity of intoxication in carbon monoxide poisoning according to the severity of metabolic acidosis and accelerates the elimination of carbon monoxide (CO) from the body.

The protective index of Acyzol with parenteral use is 1.40-1.45. Oral administration of Acyzol enhances the prophylactic and therapeutic effect against carbon monoxide, and the protective index increases to 1.6-1.8.

Acyzol reduces the body’s oxygen demand and promotes increased resistance to hypoxia in organs most sensitive to oxygen deficiency: the brain, myocardium, and liver.

Acyzol is a complex zinc-organic compound and replenishes zinc deficiency in the body.

Pharmacokinetics

When taken orally, it is rapidly absorbed from the gastrointestinal tract. C_max after a dose of 120 mg is reached in 1-1.5 hours. T_1/2 is 1-1.5 hours; trace amounts of the drug are recorded after 8-10 hours. It is mainly metabolized in the liver.

With intramuscular administration of Acyzol, C_max is reached 20-30 minutes after administration of a 60 mg (1 ml) dose and remains in the plasma for 4-5 hours. T_1/2 is 1-1.5 hours.

Indications

• Prophylactic agent in case of threat of poisoning;
• Therapeutic agent for poisoning of varying severity by carbon monoxide (CO) and other products of thermal oxidative degradation;
• For emergency medical care in emergencies when people are affected by carbon monoxide and combustion products of organic substances in the foci of large-scale disasters and chemical accidents; mine and mine rescue operations, various fires (at industrial sites, in forests), ailments caused by automobile exhausts (traffic controllers, traffic police workers) – areas of application of Acyzol.

As an antihypoxic agent, Acyzol can be used for many diseases accompanied by ischemia and hypoxia of internal organs: in therapeutic and surgical practice, in urology, gynecology, dermatology, as well as for the treatment of functional impotence.

Due to its antihypoxic and antioxidant action, Acyzol can find application in resuscitation, emergency therapy, and surgery for the correction of metabolic acidosis and protection of cell membranes from the effects of lipid peroxidation products.

Acyzol can be recommended for implementation in obstetric practice as an effective agent for fetal hypoxia.

In sports medicine, the use of Acyzol will increase performance and endurance in training processes by replenishing zinc in enzymatic systems, optimizing tissue respiration, and improving the oxygen-binding properties of blood.

Due to the presence of ionized zinc in the Acyzol dosage form, the drug can be used in the treatment of zinc-deficient conditions: Prasad’s disease, immunodeficiencies, alopecia, allergic dermatoses, prostate dysfunction, and delayed mental and physical development in children.

ICD codes

Dosage Regimen

Capsules

For prophylactic purposes, Acyzol is prescribed at a dose of 1 ml intramuscularly 20-30 minutes before or 1 capsule (120 mg) 30-40 minutes before entering a smoke-filled (gassed) area, when there is a high risk of CO inhalation, during work to eliminate the consequences of accidents and disasters accompanied by fires, or when extinguishing the fires themselves and rescuing victims.

The protective effect of Acyzol lasts for 1.5-2 hours when using the drug solution, and repeated administration is allowed 1 hour after the 1st administration. When using capsules, the protective effect lasts for 2-2.5 hours, and repeated administration of the drug is allowed after 1.5-2 hours.

Solution

For prophylactic purposes, 1 ml of Acyzol solution is administered intramuscularly when there is a threat of poisoning 20 – 30 minutes before the expected exposure to CO and thermal degradation products. Repeated administration is allowed 1 hour after the first administration.

As a therapeutic agent, Acyzol is recommended to be used as early as possible after poisoning, regardless of the severity of the lesion. The drug is administered at a dose of 1 ml intramuscularly immediately after the victim is removed from the fire area (gassed room). Subsequently, Acyzol is administered intramuscularly at 1 ml 2 – 4 times a day.

The maximum daily dose for an adult is 240 mg (4 ml).

The course of treatment averages 7 – 10 days.

Adverse Reactions

Acyzol does not exhibit side effects; in some cases, moderate pain at the injection site is possible.

Contraindications

• Hypersensitivity to the components of the drug Acyzol.

Special Precautions

The administration of Acyzol does not exclude the need for other therapeutic measures aimed at maintaining the vital functions of the body: oxygen therapy, infusion therapy.

Overdose

In case of an overdose of Acyzol, a metallic taste in the mouth, headache, and nausea are noted, which may occur during course treatment and disappear after discontinuation of the drug.

Storage Conditions

The drug should be stored in a place protected from light, at a temperature not exceeding 25°C (77°F).

Shelf Life

Shelf life – 2 years.

Dispensing Status

The drug is approved for use as an over-the-counter product.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.