Alyufost^® (Gel) Instructions for Use

Marketing Authorization Holder

Iris, LLC (Russia)

Manufactured By

Avva Rus, JSC (Russia)

ATC Code

A02AB03 (Aluminium phosphate)

Active Substance

Aluminium phosphate (DCF adopted for use in France)

Dosage Form

Alyufost®

Gel for oral administration: sachets 16 g 6 or 20 pcs.

Dosage Form, Packaging, and Composition

Gel for oral administration homogeneous from white to light yellow with a characteristic odor.

Excipients : liquid non-crystallizing sorbitol, pectin, orange flavor, agar-agar 800, potassium sorbate, calcium sulfate dihydrate, purified water.

16 g – sachets (6) – cardboard packs.
16 g – sachets (20) – cardboard packs.

Clinical-Pharmacological Group

Antacid drug

Pharmacotherapeutic Group

Acid-related disorder treatment agents; antacids; aluminum compounds

Pharmacological Action

Antacid agent. It neutralizes hydrochloric acid of gastric juice and reduces the proteolytic activity of pepsin.

It is practically not absorbed from the gastrointestinal tract and does not cause alkalosis.

By adsorbing on the gastric mucosa in the form of hydrophilic colloidal micelles, Aluminium phosphate creates a protective mucoid layer that protects the mucosa from the effects of hydrochloric acid, pepsin, and endogenous and exogenous toxic substances.

It does not cause phosphate deficiency in the body.

Pharmacokinetics

When taken orally, it has low absorption.

Most of the aluminum phosphate is insoluble; a small part is precipitated in the intestine in the form of oxides and insoluble carbonates.

Indications

Peptic ulcer of the stomach and duodenum in the acute phase, chronic gastritis with increased and normal secretory function of the stomach in the acute phase, acute gastritis, acute duodenitis, symptomatic ulcer of various origins, erosion of the gastrointestinal mucosa, reflux esophagitis, hiatal hernia, enterocolitis, sigmoiditis, proctitis, diverticulitis, diarrhea in patients after gastrectomy, dyspeptic phenomena (including those of neurotic origin, after dietary errors, taking medications, chemotherapy), acute pancreatitis, chronic pancreatitis in the acute phase, poisoning and intoxication.

For the purpose of prevention to reduce the absorption of radioactive elements.

ICD codes

Dosage Regimen

Administer orally. For adults and children over 6 years, use 1-2 sachets, 2-4 times daily.

Take the gel between meals and at bedtime. For gastro-esophageal reflux disease, take after meals.

For acute gastritis or heartburn, use a single dose of 1-2 sachets as needed.

For peptic ulcer disease, follow the regimen prescribed by your physician, typically for 1-2 months.

Open the sachet immediately before use. Squeeze the entire contents directly into the mouth and swallow.

Do not chew the gel. Follow with a small amount of water if necessary.

For children under 6 years, determine the dose individually based on body weight and medical condition.

The maximum daily dose for adults is 8 sachets. Do not exceed this limit.

For long-term therapy exceeding two weeks, ensure adequate dietary phosphate intake and monitor for constipation.

Adjust the dosing interval to at least 2-3 hours when taking other oral medications to avoid interactions.

Adverse Reactions

From the digestive system constipation (especially in elderly and bedridden patients), nausea, vomiting, change in taste sensations.

From laboratory parameters with long-term use in high doses – hypophosphatemia, hypocalcemia, increased aluminum content in the blood.

From the musculoskeletal system osteomalacia, osteoporosis.

From the CNS encephalopathy.

From the urinary system hypercalciuria, nephrocalcinosis, renal failure.

Contraindications

Renal failure, Alzheimer’s disease, hypophosphatemia, hypersensitivity to aluminum phosphate.

Use in Pregnancy and Lactation

If necessary, it can be used during pregnancy and lactation (breastfeeding).

Use in Renal Impairment

Use with caution in high doses in patients with impaired renal function (due to the possible risk of accumulation of aluminum phosphate, leading to constipation). In patients with concomitant renal failure, thirst, decreased blood pressure, and decreased reflexes are possible.

Geriatric Use

Use with caution in high doses in elderly patients (due to the possible risk of accumulation of aluminum phosphate, leading to constipation).

Special Precautions

Use with caution in high doses in elderly patients and in patients with impaired renal function (due to the possible risk of accumulation of aluminum phosphate, leading to constipation).

In patients with concomitant renal failure, thirst, decreased blood pressure, and decreased reflexes are possible.

Drug Interactions

Aluminum preparations used as antacids interact with most oral medications both by changing the pH of gastric juice and rapid gastric emptying, and by adsorption with the formation of complexes that are not absorbed.

With simultaneous use, citrates and ascorbic acid increase the absorption of aluminum from the gastrointestinal tract.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.