Artishok (Tablets) Instructions for Use

Marketing Authorization Holder

Canonpharma Production, CJS (Russia)

ATC Code

A05AX (Other drugs for the treatment of biliary tract diseases)

Active Substance

Cynara (BAN)

Dosage Form

Artishok

Film-coated tablets, 200 mg: 30, 60, or 180 pcs.

Dosage Form, Packaging, and Composition

Film-coated tablets from brown to dark brown in color, round, biconvex; on the cross-section, the core is from light brown to dark brown in color, with inclusions of a lighter color.

Excipients: corn starch pregelatinized – 22 mg, light magnesium trisilicate – 12 mg, magnesium stearate – 3.75 mg, Prosolv (microcrystalline cellulose type 102 – 98%, colloidal silicon dioxide – 2%) – 59.25 mg, talc – 3 mg.

Coating: IsuPolish^® R brown 385.04 FSC 50 mg, incl.: hypromellose – 12.5 mg, gum arabic – 1.5 mg, sucrose – 22.5 mg, talc – 3 mg, titanium dioxide – 1 mg, iron oxide yellow dye – 3.5 mg, iron oxide red dye – 3.5 mg, iron oxide black dye – 2.5 mg.

10 pcs. – contour cell packs (3) – cardboard packs.
10 pcs. – contour cell packs (6) – cardboard packs.
30 pcs. – contour cell packs (1) – cardboard packs.
30 pcs. – contour cell packs (2) – cardboard packs.
30 pcs. – contour cell packs (6) – cardboard packs.
60 pcs. – jars (1) – cardboard packs.
180 pcs. – jars (1) – cardboard packs.

Clinical-Pharmacological Group

Herbal preparation with choleretic and diuretic effect

Pharmacotherapeutic Group

Choleretic agent of plant origin

Pharmacological Action

Herbal preparation. The phenolic compound cynarin, in combination with phenolic acids (caffeic, chlorogenic, neochlorogenic, cryptochlorogenic), exerts a choleretic and hepatoprotective effect.

It increases the excretion of urea, toxins (including nitro compounds, alkaloids), and heavy metal salts from the body. It helps to reduce the cholesterol content in the blood.

The ascorbic acid, carotene, vitamins B₁ and B₂, rutin, and inulin contained in artichoke contribute to the normalization of metabolic processes.

Indications

As an additional agent for biliary dyskinesia of the hypokinetic type, cholecystitis, chronic hepatitis, anorexia, chronic intoxications (with hepatotoxic substances, nitro compounds, alkaloids, heavy metal salts), chronic renal failure, urolithiasis, uraturia, atherosclerosis, obesity.

ICD codes

Dosage Regimen

Take tablets orally with a sufficient amount of water.

For adults and children over 12 years of age, the standard dose is one 200 mg tablet taken two to three times daily.

Administer the dose before meals to optimize the choleretic effect.

The maximum daily dose for adults is 600 mg, equivalent to three tablets.

The duration of treatment is typically two to four weeks.

Adjust the regimen based on the underlying condition and therapeutic response.

For biliary dyskinesia and cholecystitis, use the standard regimen to stimulate bile secretion.

In chronic hepatitis and toxic liver damage, employ the standard dose for hepatoprotective support.

For chronic renal failure and uraturia, use the standard regimen to support diuresis and urea excretion.

In cases of atherosclerosis and hypercholesterolemia, administer the standard dose to help reduce blood cholesterol levels.

For anorexia, take tablets before meals to stimulate appetite.

In obesity management, use as an adjunct to a comprehensive weight loss program.

Do not exceed the recommended maximum daily dose.

Discontinue use if diarrhea or allergic skin reactions occur.

Consult a physician if symptoms persist or worsen after two weeks of treatment.

Adverse Reactions

Allergic reactions skin manifestations.

From the digestive system with prolonged use in high doses – diarrhea.

Contraindications

Acute diseases of the liver, biliary tract, kidneys, urinary tract, gastrointestinal tract; large stones in the biliary and urinary tracts; biliary dyskinesia of the hyperkinetic type; hypersensitivity to artichoke.

Use in Pregnancy and Lactation

Data on the safety of artichoke use during pregnancy and lactation are not available.

Use in Hepatic Impairment

Contraindicated in acute liver diseases.

Use in Renal Impairment

Contraindicated in acute kidney diseases.

Pediatric Use

Use in dosage forms intended for this category of patients.

Special Precautions

At the beginning of treatment, in some cases, an increase in blood cholesterol levels is possible, then this indicator normalizes and even decreases.

In children, use in dosage forms intended for this category of patients.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.