B-Vitacaps (Capsules) Instructions for Use

Marketing Authorization Holder

Minskintercaps Up (Republic Of Belarus)

ATC Code

A11JA (Vitamins in combination)

Dosage Form

B-Vitacaps

Capsules: 20 pcs.

Dosage Form, Packaging, and Composition

10 pcs. – blister packs (2) – cardboard packs.

Clinical-Pharmacological Group

Multivitamins

Pharmacotherapeutic Group

Multivitamin

Pharmacological Action

Thiamine mononitrate (vitamin B₁)

In the body, as a result of phosphorylation processes, it is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions.

It plays an important role in carbohydrate, protein, and fat metabolism, as well as in the processes of nerve impulse transmission at synapses. It protects cell membranes from the toxic effects of lipid peroxidation products.

Riboflavin (vitamin B₂)

It has a metabolic effect, interacts with ATP, forming coenzymes of flavoproteins – flavin adenine mononucleotide and flavin adenine dinucleotide, which are components of enzymes such as succinate dehydrogenase, cytochrome reductase, diaphorase, amino acid oxidases, etc. By regulating redox processes, it participates in H^– transfer, tissue respiration, carbohydrate, protein, and fat metabolism, in maintaining normal visual function of the eye, and in the synthesis of Hb and erythropoietin.

Riboflavin-activated pyridoxal kinase converts pyridoxine (vitamin B₆) into the active form pyridoxal phosphate. It promotes the conversion of tryptophan to niacin and the preservation of erythrocyte integrity.

It is part of glutathione reductase and xanthine oxidase.

It is synthesized by the normal intestinal microflora and is itself necessary for its maintenance.

Nicotinamide (vitamin B₃, vitamin PP)

It is structurally similar to nicotinic acid. It is an important component of codehydrogenase I (NAD) and codehydrase II (NADP), which are involved in redox processes in the cell. It participates in the metabolism of fats, proteins, amino acids, purines, tissue respiration, and glycogenolysis.

Pyridoxine (vitamin B₆)

It participates in metabolism and is necessary for the normal functioning of the central and peripheral nervous system. Upon entering the body, it is phosphorylated, converted into pyridoxal-5-phosphate, and becomes part of enzymes that carry out the decarboxylation and transamination of amino acids. It participates in the metabolism of tryptophan, methionine, cysteine, glutamic acid, and other amino acids. It plays an important role in histamine metabolism. It helps normalize lipid metabolism. Isolated pyridoxine deficiency is very rare, mainly in children on special artificial nutrition (manifested by diarrhea, convulsions, anemia, and peripheral neuropathy may develop).

Calcium pantothenate

A pantothenic acid preparation with metabolic action. Pantothenic acid is part of coenzyme A, playing an important role in acetylation and oxidation processes, and participates in carbohydrate and fat metabolism, and in the synthesis of acetylcholine and steroid hormones. It improves the energy supply of the myocardial contractile function and accelerates regeneration processes.

Colecalciferol

A means of replenishing vitamin D₃ deficiency. It participates in the regulation of calcium-phosphorus metabolism, enhances the absorption of Ca^2- and phosphates in the intestine (by increasing the permeability of cellular and mitochondrial membranes of the intestinal epithelium) and their reabsorption in the renal tubules of the kidneys; promotes bone mineralization, the formation of the bone skeleton and teeth in children, enhances the ossification process, and is necessary for the normal functioning of the parathyroid glands.

Indications

• Prevention and treatment of vitamin deficiency (including during periods of intense mental and physical demands; in conditions accompanied by an increased need for vitamins).

ICD codes

Dosage Regimen

Take this medication orally.

Swallow one capsule daily.

Administer the dose after a meal to improve tolerability and absorption.

Take with a full glass of water (approximately 100 ml).

Do not exceed the recommended daily dosage.

For long-term use, maintain a consistent daily schedule.

If a dose is missed, take it as soon as remembered; do not double the dose to catch up.

This regimen is for the prevention and treatment of vitamin deficiencies.

It is also indicated during periods of increased physical or mental stress.

Consult a physician for use beyond continuous long-term supplementation.

Adverse Reactions

Thiamine allergic reactions (urticaria, skin itching, angioedema, rarely – anaphylactic shock), increased sweating, tachycardia.

Nicotinamide peptic ulcer of the stomach and duodenum (in the acute stage).

Calcium pantothenate nausea, vomiting, heartburn.

Caution should be exercised when prescribing large doses of the drug (contains pyridoxine) to patients with coronary heart disease.

With long-term use of large doses of nicotinamide, glucose tolerance may decrease.

Contraindications

Hypersensitivity to the components of the drug.

Special Precautions

To enhance the effect of the vitamins contained in the drug, methionine or methionine-containing products (cottage cheese, buckwheat porridge, walnuts, etc.) should be consumed when taking it.

Drug Interactions

Thiamine

It is unstable in alkaline and neutral solutions; co-administration with carbonates, citrates, barbiturates, and Cu²⁺ is not recommended. Ethanol slows down the rate of thiamine absorption after oral administration.

Riboflavin

It reduces the activity of doxycycline, tetracycline, oxytetracycline, erythromycin, and lincomycin. It is incompatible with streptomycin.

Chlorpromazine, imipramine, amitriptyline, by blocking flavokinase, impair the incorporation of riboflavin into flavin adenine mononucleotide and flavin adenine dinucleotide and increase its excretion in the urine.

Ethanol, tricyclic antidepressants, phenothiazines, and drugs that block tubular secretion reduce absorption (require an increase in the dose of riboflavin).

M-cholinoblockers increase absorption and bioavailability (reduce intestinal motility).

Thyroid hormones accelerate metabolism.

It reduces and prevents the side effects of chloramphenicol (impaired hematopoiesis, optic neuritis).

It is compatible with drugs that stimulate hematopoiesis, antihypoxants, and anabolic steroids.

Pyridoxine

It enhances the effect of diuretics; weakens the activity of levodopa.

Isonicotinic acid hydrazide, penicillamine, cycloserine, and estrogen-containing oral contraceptives weaken the effect of pyridoxine.

It combines well with cardiac glycosides (pyridoxine promotes increased synthesis of contractile proteins in the myocardium), with glutamic acid and asparkam (increases resistance to hypoxia).

It is pharmaceutically incompatible with vitamins B₁ and B12, and in powder form with ascorbic and nicotinic acids.

Calcium pantothenate

It increases the cardiotonic effect of cardiac glycosides and reduces the toxic effect of streptomycin and other anti-tuberculosis drugs.

Colecalciferol

The toxic effect is weakened by vitamin A, tocopherol, ascorbic acid, pantothenic acid, thiamine, Riboflavin, pyridoxine. In hypervitaminosis D, the effect of cardiac glycosides may be enhanced and the risk of arrhythmia may increase due to the development of hypercalcemia (adjustment of the cardiac glycoside dose is advisable).

Under the influence of barbiturates (including phenobarbital), phenytoin, and primidone, the need for colecalciferol may significantly increase (they increase the metabolic rate).

Long-term therapy with simultaneous use of AL^3- and Mg²⁺-containing antacids increases their concentration in the blood and the risk of intoxication (especially in the presence of chronic renal failure).

Calcitonin, derivatives of etidronic and pamidronic acids, plicamycin, gallium nitrate, and corticosteroids reduce the effect.

Cholestyramine, colestipol, and mineral oils reduce the absorption of fat-soluble vitamins in the gastrointestinal tract and require an increase in their dosage.

It increases the absorption of phosphorus-containing drugs and the risk of hyperphosphatemia. When used simultaneously with sodium fluoride, the interval between doses should be at least 2 hours; with oral forms of tetracyclines – at least 3 hours.

Concomitant use with other analogues of vitamin D increases the risk of hypervitaminosis.

Storage Conditions

The drug should be stored in a light-protected place at a temperature of (15-25)°C.

Keep out of reach of children.

Shelf Life

Shelf life 2 years.

Do not use after the expiration date printed on the packaging.

Dispensing Status

The drug is approved for use as an over-the-counter product.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.