Brusniver (Herbal mixture) Instructions for Use

Marketing Authorization Holder

Krasnogorskleksredstva, JSC (Russia)

ATC Code

G04BX (Other drugs for the treatment of urological diseases)

Dosage Form

Brusniver

Herbal mixture – powder 2 g: filter bags 10 or 20 pcs.

Dosage Form, Packaging, and Composition

2 g – filter bags (10) – carton packs.
2 g – filter bags (20) – carton packs.

Clinical-Pharmacological Group

Herbal preparation with diuretic, antimicrobial, and anti-inflammatory action

Pharmacotherapeutic Group

Herbal diuretic agent

Pharmacological Action

The mixture has antimicrobial activity against staphylococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus, and some other microorganisms. It has an anti-inflammatory and diuretic effect.

Indications

• Use in the complex therapy of inflammatory diseases of the urinary tract, including cystitis, urethritis, pyelonephritis, and prostatitis.
• Use in the complex therapy of inflammatory diseases in gynecology, including salpingitis, oophoritis, endometritis, and cervicitis.
• Use in the complex therapy of inflammatory diseases in proctology, including proctitis.

ICD codes

Dosage Regimen

Prepare the decoction or infusion immediately before use. Place 1 filter bag in an enamel or glass container, pour 200 ml (1 cup) of boiling water, cover, and infuse for 15 minutes, then squeeze the bag.

For oral administration, take the prepared infusion 3-4 times daily. For topical use, apply the prepared infusion or decoction 1-3 times daily, using it for irrigation, lotions, or sitz baths as directed.

The duration of therapy is determined by the physician based on the disease severity and clinical response.

Adverse Reactions

Allergic reactions, including skin rash, itching, urticaria, and redness, may occur.

Discontinue use immediately and consult a physician if any adverse reactions are observed.

Drug Interactions

Concurrent use with other diuretics may potentiate the diuretic effect, requiring possible dose adjustment. Exercise caution with concurrent use of photosensitizing drugs due to the presence of St. John’s Wort.

Monitor for reduced efficacy when used concomitantly with drugs metabolized by cytochrome P450 isoenzymes, as St. John’s Wort is a known inducer.

Contraindications

• Do not use in case of known hypersensitivity to any plants in the mixture: cowberry leaves, St. John’s Wort herb, tripartite beggarticks herb, or rose hips.
• Do not use in patients with a history of photosensitivity reactions.
• Contraindicated in severe renal impairment where diuresis is undesirable.

Overdose

Symptoms of overdose may include severe nausea, vomiting, and dizziness due to excessive diuresis. Discontinue use immediately and initiate symptomatic and supportive treatment.

Ensure adequate hydration and correct electrolyte imbalances if they occur. Seek immediate medical attention for management of severe symptoms.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.