Carbopekt (Capsules) Instructions for Use

Marketing Authorization Holder

Medisorb, JSC (Russia)

ATC Code

A07BA01 (Activated charcoal)

Active Substance

Activated charcoal (BP British Pharmacopoeia)

Dosage Form

Carbopekt

Capsules 110 mg: 20 and 50 pcs.

Dosage Form, Packaging, and Composition

10 pcs. – blister packs (2) – cardboard packs.
10 pcs. – blister packs (5) – cardboard packs.

Clinical-Pharmacological Group

Enterosorbent

Pharmacotherapeutic Group

Enterosorbent agent

Pharmacological Action

Adsorbent agent. It has enterosorbing, detoxifying, and antidiarrheal effects. It belongs to the group of polyvalent physicochemical antidotes and has high surface activity.

It adsorbs poisons and toxins from the gastrointestinal tract before their absorption, including alkaloids, glycosides, barbiturates and other hypnotic and narcotic drugs, salts of heavy metals, toxins of bacterial, plant, and animal origin, phenol derivatives, hydrocyanic acid, sulfonamides, and gases.

It also adsorbs excess of some metabolic products – bilirubin, urea, cholesterol, endogenous metabolites responsible for the development of endogenous toxicosis. It poorly adsorbs acids and alkalis (including iron salts, cyanides, methanol, ethylene glycol). It does not irritate the gastrointestinal mucosa.

Pharmacokinetics

Not absorbed, not broken down, completely excreted through the gastrointestinal tract within 24 hours.

Indications

Exogenous and endogenous intoxications of various origins (as a detoxifying agent). Foodborne toxic infections, dysentery, salmonellosis (as part of complex treatment). Poisoning by drugs (psychotropic, hypnotic, narcotic drugs, etc.), alkaloids, salts of heavy metals, and other poisons.

Gastrointestinal diseases accompanied by dyspepsia and flatulence. Food and drug allergy. Hyperbilirubinemia, hyperazotemia. To reduce gas formation in the intestine before ultrasound and X-ray examinations. For the prevention of chronic intoxications in hazardous production.

ICD codes

Dosage Regimen

Administer orally.

For adults, use 3-6 capsules three to four times daily.

For acute intoxications and poisonings, initiate with a loading dose of 20-30 grams (approximately 180-270 capsules).

For gastric decontamination, administer after gastric lavage.

For pediatric patients aged 3 to 7 years, prescribe 1-2 capsules three to four times daily.

For pediatric patients aged 7 to 14 years, prescribe 2-3 capsules three to four times daily.

Adjust the total daily dose and duration based on the severity of the condition and clinical response.

For reducing gas before diagnostic procedures, use the standard adult dose on the day preceding the examination.

Take at least 1 hour before or 2 hours after meals and administration of other medications.

Swallow capsules whole with a full glass of water.

Adverse Reactions

Possible dyspepsia, constipation, diarrhea, dark coloration of feces; with long-term use – hypovitaminosis, impaired absorption of nutrients from the gastrointestinal tract.

Contraindications

Hypersensitivity to activated charcoal, ulcerative lesions of the gastrointestinal tract (including gastric and duodenal ulcer, ulcerative colitis), gastrointestinal bleeding, simultaneous administration of antitoxic drugs whose effect develops after absorption (including methionine), intestinal atony; children under 3 years of age.

With caution

In patients with diabetes mellitus and persons on a low-carbohydrate diet.

Use in Pregnancy and Lactation

Can be used during pregnancy and breastfeeding as prescribed by a doctor.

Pediatric Use

Contraindicated for use in children under 3 years of age.

Special Precautions

When treating intoxications, it is necessary to create an excess of activated charcoal in the stomach (before its lavage) and in the intestine (after gastric lavage).

A decrease in the concentration of activated charcoal in the medium promotes desorption of the bound substance and its absorption (to prevent resorption of the released substance, repeated gastric lavage and administration of activated charcoal are recommended).

The presence of food masses in the gastrointestinal tract requires the administration of charcoal in high doses, as the contents of the gastrointestinal tract are adsorbed by charcoal and its activity decreases.

If poisoning is caused by substances involved in enterohepatic circulation (cardiac glycosides, indomethacin, morphine and other opiates), activated charcoal should be used for several days.

Drug Interactions

Activated charcoal has adsorbing properties and, when taken simultaneously with other drugs, can significantly reduce their absorption from the gastrointestinal tract, which leads to a decrease in the effectiveness of other drugs.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.