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Caripazym (Lyophilisate) Instructions for Use

ATC Code

D03BA (Proteolytic enzymes)

Clinical-Pharmacological Group

Drug with proteolytic activity for external use

Pharmacotherapeutic Group

Topical proteolytic agent

Pharmacological Action

A proteolytic agent for external use that breaks down necrotized tissues, liquefies viscous secretions, exudate, and blood clots. Its action is similar to chymotrypsin and trypsin.

Pharmacokinetics

When applied externally, the drug is not absorbed and does not have a systemic effect on the body. The enzymes that are part of Caripazym are destroyed and completely biotransformed in the liver.

Indications

  • Third-degree IIIa burns (to accelerate the rejection of scabs and cleanse granulating wounds from remnants of purulent-necrotic tissues).

ICD codes

ICD-10 code Indication
T30 Burns and corrosions of unspecified body region
ICD-11 code Indication
NE11 Burn of unspecified body region

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Lyophilisate

Externally, in the form of solutions with concentrations of 17.5 IU/ml, 35 IU/ml, or 70 IU/ml, depending on the thickness of the scab. The solutions are prepared in a 0.5% novocaine solution or a 0.9% isotonic sodium chloride solution. A napkin moistened with the preparation is applied to the burn surface and covered with a waterproof bandage. No more than 30% of the total body surface area is treated simultaneously. The bandage is changed once a day or once every 2 days, removing the detached necrotic tissues. The course of treatment is 4-12 days.

Adverse Reactions

Allergic reactions.

Contraindications

  • Pregnancy, lactation period;
  • Increased individual sensitivity to the drug.

Use in Pregnancy and Lactation

Contraindicated during pregnancy and lactation.

Special Precautions

Influence on the ability to drive vehicles and mechanisms

The drug does not have a negative effect on the ability to drive a car or work with mechanisms.

Overdose

Cases of overdose have not been described.

Drug Interactions

No clinically significant interactions of caripazim with other drugs have been established.

Storage Conditions

In a dry place, protected from light, at a temperature from 2°C (35.6°F) to 8°C (46.4°F). Keep out of reach of children.

Shelf Life

Shelf life is 2 years.

Dispensing Status

By prescription.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Marketing Authorization Holder

Vifitech, CJSC (Russia)

Dosage Form

Bottle Rx Icon Caripazym Lyophilizate for preparation of solution for external use 350 IU: vial 1 pc.

Dosage Form, Packaging, and Composition

Lyophilizate for preparation of solution for external use in the form of a white with a yellowish tint lyophilized powder or porous mass with a faint characteristic odor.

1 vial
Papaya milk juice extract (procaripazim dry extract) 350 IU

350 IU – glass vials with a capacity of 10 ml (1) – cardboard packs.
350 IU – glass vials with a capacity of 10 ml (5) – contour cell packs (1) – cardboard packs.
350 IU – glass vials with a capacity of 10 ml (5) – contour cell packs (2) – cardboard packs.

Marketing Authorization Holder

I.G. Kutateladze Institute of Pharmacochemistry of the Academy of Sciences of Georgia (Georgia)

Dosage Form

Bottle Rx Icon Caripazym Lyophilizate for preparation of solution for external use 350 IU: vial 1 pc.

Dosage Form, Packaging, and Composition

Lyophilizate for preparation of solution for external use in the form of a powder or porous mass of white color with a yellowish tint, odorless.

1 vial
Enzymes from dried papaya milk juice (papain, chymopapain A, chymopapain B, peptidase A and B, lysozyme – a mucolytic enzyme), with total proteolytic activity 350 IU

350 IU – vials (1) – cardboard packs.

Marketing Authorization Holder

Medflorina, LLC (Russia)

Dosage Form

Bottle Rx Icon Caripazym Lyophilizate for preparation of solution for external use 350 IU: vial 1 or 10 pcs.

Dosage Form, Packaging, and Composition

Lyophilizate for preparation of solution for external use (dry porous mass, in the form of a tablet, whole or crumbled) white or white with a slightly yellowish tint.

1 vial
Papain 350 IU

350 IU – glass vials with a capacity of 10 ml (1) – cardboard packs.
350 IU – glass vials with a capacity of 10 ml (10) – cardboard packs.

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