Centrum Silver (Tablets) Instructions for Use

Marketing Authorization Holder

Wyeth Canada (Canada)

ATC Code

A11AA (Multivitamins in combination with minerals)

Dosage Form

Centrum Silver

Coated tablets: 25, 50, or 100 pcs.

Dosage Form, Packaging, and Composition

Coated tablets of orange color, oval, with a score line and an engraving “U” on the left and “23” on the right of the line on one side; the other side of the tablet has no score line, with an engraving “WR”.

Excipients: lactose monohydrate, microcrystalline cellulose, crospovidone, magnesium stearate, stearic acid, siloid 244.

Coating composition: light mineral oil, triethyl citrate, polysorbate 80, Opadry orange YS-1-13118 dye (hypromellose, titanium dioxide (E171), sunset yellow (E110)).

25 pcs. – polyethylene bottles (1) – cardboard packs.
50 pcs. – polyethylene bottles (1) – cardboard packs.
100 pcs. – polyethylene bottles (1) – cardboard packs.

Clinical-Pharmacological Group

Multivitamins with macro- and microelements

Pharmacotherapeutic Group

Multivitamin agent + multimineral

Pharmacological Action

The pharmacological properties of the drug Centrum Silver are determined by the properties of the vitamins and minerals included in its composition.

Vitamin A is actively involved in redox processes, the synthesis of mucopolysaccharides, proteins, lipids, and in mineral metabolism. It contributes to the normal condition of skin epithelial cells and mucous membranes.

Vitamin E has antioxidant properties, prevents the formation of free radicals and maintains the stability of cell membranes, promotes the accumulation of glycogen in muscles and normalizes metabolic processes in them, and helps slow down the aging processes of body tissues.

Vitamin D (Colecalciferol) is a regulator of calcium-phosphorus metabolism in the body, preventing the development of osteomalacia and osteoporosis.

Vitamin C (Ascorbic acid) is involved in the synthesis of collagen, which contributes to the formation and maintenance of the structure and functions of blood vessel cells, bone tissue, and skin; it promotes wound healing.

Water-soluble B vitamins are involved in the biosynthesis and conversion of amino acids, fatty acids, energy metabolism, and redox processes.

Vitamin B1 (Thiamine) normalizes the activity of the nervous, cardiovascular, and endocrine systems.

Vitamin B2 (Riboflavin) improves the condition of the skin, mucous membranes, and liver; it protects the retina from the negative effects of ultraviolet rays.

Vitamin B6 (pyridoxine hydrochloride) is actively involved in protein metabolism and has a beneficial effect on the functions of the nervous system and liver.

Vitamin B12 (Cyanocobalamin) is necessary for hematopoiesis, myelin synthesis, and the normal functioning of the nervous system.

Pantothenic acid is an important factor for the metabolism of carbohydrates, fats, and amino acids.

Folic acid plays an important role in the metabolism of nucleic acids and proteins. It is necessary for normal hematopoiesis.

Biotin is an important component of a number of enzymes and is involved in the metabolism of carbohydrates, fats, and proteins.

Iron is involved in erythropoiesis and, as part of hemoglobin, ensures the transport of oxygen to tissues.

Magnesium (magnesium oxide) enhances the body’s defenses.

Iodine is involved in the functioning of the thyroid gland, ensuring the formation of its hormones – thyroxine and triiodothyronine.

Copper (copper oxide) is involved in nitrogen metabolism, the formation of hemoglobin, and the formation of red blood cells.

Phosphorus (calcium phosphate) strengthens bone tissue and teeth.

Calcium (calcium phosphate) is involved in the formation of bones, dentin, and tooth enamel, and reduces vascular wall permeability.

Zinc (zinc oxide) is part of many enzymes and is a component of a number of vital hormones.

Manganese (manganese sulfate) is involved in fat metabolism and is a necessary component for the normal structure of bones.

Molybdenum (sodium molybdate) activates enzymes involved in the metabolic processes of carbohydrates, fats, and iron.

Potassium (Potassium Chloride) is a basic element in every living cell, regulates intracellular metabolism, water and salt balance, activates a number of enzymes, and participates in the most important metabolic processes.

Chromium (Chromium Chloride) is involved in the processes of regulating blood sugar levels.

Selenious acid solution 0.9% in 90% 2,2-dichloropropionic acid (sodium selenate) stimulates immunity and is an antioxidant. It contributes to the normal development of the cell.

Nickel (nickel sulfate) is directly involved in metabolism and is necessary for the normal development of the body.

Tin (tin (II) chloride) is involved in protein synthesis.

Silicon (sodium metasilicate) plays an important role in the formation of bone tissue and promotes the development of skin.

Vanadium regulates cholesterol levels, stimulates glucose utilization, and activates DNA synthesis.

Indications

• Prevention of vitamin and mineral deficiency in men and women over 50 years of age;
• Inadequate and unbalanced nutrition;
• Seasonal prevention of hypovitaminosis.

ICD codes

Dosage Regimen

Take one tablet orally once daily.

Swallow the tablet whole with a full glass of water.

Take with food to improve tolerance and enhance absorption of fat-soluble vitamins.

Do not crush or chew the tablet before swallowing.

For adults 50 years of age and older only.

Adhere strictly to the one tablet per day dosage; do not exceed this recommended intake.

Consistent daily intake is necessary for optimal benefit.

Consult a healthcare professional before use, particularly if you have any pre-existing medical conditions or are taking other medications.

Discontinue use and seek medical advice if any adverse reactions occur.

Store the bottle tightly closed in a cool, dry place to protect the product from moisture and light.

Adverse Reactions

Allergic reactions.

Contraindications

• Hypersensitivity to the components of the drug.

Special Precautions

Urine may turn bright yellow (completely harmless and due to the presence of riboflavin in the preparation). Do not exceed the recommended daily dose.

Drug Interactions

Concomitant use of other multivitamin complexes is not recommended.

Storage Conditions

At a temperature not exceeding 25°C (77°F) in a dry place. Keep out of reach of children.

Shelf Life

Shelf life – 2 years.

Dispensing Status

Over-the-counter.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.