D-panthenol-Nizhpharm-plus (Cream) Instructions for Use

Marketing Authorization Holder

Nizhpharm JSC (Russia)

ATC Code

D08AC52 (Chlorhexidine in combination with other drugs)

Active Substances

Dexpanthenol (Rec.INN registered by WHO)

Chlorhexidine (Rec.INN registered by WHO)

Dosage Form

D-panthenol-Nizhpharm-plus

Cream for external use 52.5 mg+8.02 mg/1 g: tubes 25 g, 30 g or 50 g

Dosage Form, Packaging, and Composition

Cream for external use white or almost white in color.

Excipients: propylene glycol – 100 mg, macrogol cetostearyl ether (Eumulgin B2) – 16 mg, cetostearyl alcohol (cetyl alcohol not more than 60%, stearyl alcohol not less than 40%) (Lanette O) – 54 mg, liquid paraffin (medical vaseline oil) – 100 mg, vaseline – 100 mg, sodium hydrogen phosphate dodecahydrate – 0.2 mg, potassium dihydrogen phosphate – 7.8 mg, purified water – up to 1 g.

25 g – aluminum tubes (1) – cardboard packs.
30 g – aluminum tubes (1) – cardboard packs.
50 g – aluminum tubes (1) – cardboard packs.

Clinical-Pharmacological Group

A drug improving trophism and tissue regeneration, with antimicrobial activity for external use

Pharmacotherapeutic Group

Tissue repair stimulant

Pharmacological Action

A combined drug that improves trophism and tissue regeneration, with antimicrobial activity for external use.

Dexpanthenol is a B vitamin, which is metabolized in the body to pantothenic acid, a component of coenzyme A involved in acetylation processes, carbohydrate and fat metabolism, and the synthesis of acetylcholine, corticosteroids, and porphyrins.

It stimulates skin regeneration, normalizes cellular metabolism, accelerates mitosis, and increases the strength of collagen fibers. It has regenerating, vitamin, metabolic, and anti-inflammatory effects.

Chlorhexidine is an antimicrobial drug, an antiseptic.

Active against gram-positive and gram-negative bacteria, including Staphylococcus spp., Enterococcus spp., Pseudomonas aeruginosa, Escherichia coli, Streptococcus spp., as well as yeast-like fungi and dermatophytes.

It retains activity in the presence of blood, pus, various secretions, and organic substances.

The Depantol cream protects the wound surface from infections, suppresses the course of the infectious process, and accelerates healing.

Pharmacokinetics

Pharmacokinetic data for the drug are not provided.

Indications

• Wound treatment when there is a risk of infection (including abrasions, cuts, scratches, cracks, excoriations, insect bites, burns, trophic ulcers);
• Postoperative wound treatment;
• Treatment of infected wounds, burns (including sunburns), bedsores, abrasions, cuts, cracks, trophic ulcers, intertrigo;
• Treatment of infected dermatoses (including eczema and atopic dermatitis).
• Diaper dermatitis, scratches with signs of infection in children;
• Cracks and inflammation of the mammary gland nipples with signs of infection in nursing mothers.

ICD codes

Dosage Regimen

Apply a thin layer of the cream to the affected skin area one to several times daily as indicated by the clinical condition.

For postoperative wounds, burns, and trophic ulcers, apply after standard cleansing and debridement of the wound surface.

For infected dermatoses such as eczema, apply to the inflamed and weeping areas to suppress bacterial growth and promote healing.

In nursing mothers with cracked or inflamed nipples, apply the cream to the nipple surface after each breastfeeding session; cleanse the area prior to the next feeding.

For infants and children with diaper dermatitis or infected scratches, apply to the affected areas after each diaper change or following a gentle cleansing with water.

For sunburns and superficial injuries like abrasions and insect bites, apply gently to cover the entire affected area.

The duration of treatment is determined by the rate of healing and the resolution of infection; discontinue if signs of irritation or hypersensitivity appear.

Adverse Reactions

Possible allergic reactions.

Contraindications

• Hypersensitivity to the components of the drug.

Use in Pregnancy and Lactation

During pregnancy and lactation, the use of the drug on large areas should be avoided.

Pediatric Use

Can be used as indicated.

Special Precautions

Avoid getting the cream into the eyes.

Overdose

Data on drug overdose are not provided.

Drug Interactions

Chlorhexidine is incompatible with soap and other anionic substances.

Storage Conditions

Keep out of reach of children at a temperature not exceeding 25°C (77°F).

Shelf Life

Shelf life – 2 years.

Dispensing Status

The drug is approved for use as an over-the-counter product.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.