Dethreevit (Liquid) Instructions for Use

Marketing Authorization Holder

Active Generation, LLC (Russia)

Manufactured By

Biolux NPO, LLC (Russia)

Dosage Form

Dethreevit

Oral liquid: 10 ml – 30 ml bottle with dropper-dispenser

Dosage Form, Packaging, and Product Composition

Composition per 1 drop (0.025 ml): vitamin D3 (cholecalciferol) 10 mcg (400 IU).

Dosage form and packaging: liquid for oral administration, in bottles of 10-30 ml volume.

Therapeutic Category

Dietary supplement for strengthening bone tissue and preventing osteoporosis

Properties

A preparation that regulates calcium and phosphorus metabolism. It replenishes vitamin D3 deficiency.

It enhances calcium absorption in the intestines and phosphorus reabsorption in the renal tubules. It promotes the formation of the bone skeleton and teeth in children, preserves bone structure, and is an anti-rachitic agent.

Vitamin D is necessary for the normal functioning of the parathyroid glands.

Scope of Application

Of the Dethreevit product

Recommended as a dietary supplement to food – an additional source of vitamin D.

Indications

• Use as a dietary supplement for the additional intake of vitamin D3.
• Employ for the correction of vitamin D deficiency as indicated by the relevant ICD-10 and ICD-11 codes.

ICD codes

Dosage Regimen

Administer orally once daily with meals. For adults and children over 6 years of age, the dose is one drop (10 mcg or 400 IU).

Adhere to a treatment duration of three to four weeks. Do not exceed the recommended daily dosage. This product is a dietary supplement and is not a medicine.

Adverse Reactions

Monitor for signs of hypercalcemia and hypercalciuria. These conditions may manifest as nausea, constipation, anorexia, polyuria, fatigue, and renal calcareous deposits.

Discontinue use immediately if hypersensitivity reactions such as pruritus, rash, or urticaria occur. In cases of prolonged excessive intake, soft tissue calcification and impaired renal function may develop.

Drug Interactions

Exercise caution with concomitant use of thiazide diuretics, as this increases the risk of hypercalcemia.

Avoid concurrent administration with other vitamin D analogs and high-dose calcium supplements. Anticonvulsants, corticosteroids, and cholestyramine may reduce the effects of vitamin D. Monitor for interactions with cardiac glycosides, as hypercalcemia may potentiate their toxic effects.

Contraindications

• Hypersensitivity to cholecalciferol or any excipient.
• Pre-existing hypercalcemia or hypercalciuria.
• Presence of renal stones, sarcoidosis, or prolonged immobilization.
• Contraindicated during pregnancy and lactation.

Consult a physician prior to initiation of therapy.

Overdose

Symptoms of overdose are primarily due to hypervitaminosis D and hypercalcemia. These include gastrointestinal disturbances, weakness, headache, and renal impairment.

In case of suspected overdose, discontinue use immediately and ensure adequate hydration. Seek immediate medical attention. Treatment is symptomatic and includes withdrawal of the supplement, a low-calcium diet, and correction of electrolyte imbalances. In severe cases, loop diuretics and corticosteroids may be administered.

Use During Pregnancy and Lactation

Contraindicated during pregnancy and lactation.

Dispensing Status

Sold to the public through pharmacy networks and specialized departments of the retail network.

Storage Conditions

Store in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C (77°F).

Shelf Life

Shelf life – 3 years. Shelf life of the opened package is no more than 4 months.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.