Dexpanthenol (Ointment, Foam) Instructions for Use

Instructions
Dosage forms

ATC Code

D03AX03 (Dexpanthenol)

Active Substance

Dexpanthenol (Rec.INN registered by WHO)

Clinical-Pharmacological Group

A drug improving trophism and tissue regeneration, for external use

Pharmacotherapeutic Group

Tissue repair stimulant

Pharmacological Action

Dexpanthenol is a derivative of pantothenic acid. Pantothenic acid is a water-soluble B-group vitamin and is a component of coenzyme A.

It stimulates skin regeneration, normalizes cell metabolism, and increases the strength of collagen fibers.

An increased need for pantothenic acid is observed when the skin or tissues are damaged, and its deficiency can be compensated for by the topical application of dexpanthenol.

Its optimal molecular weight, hydrophilicity, and low polarity enable it to penetrate all layers of the skin.

It has a regenerating and weak anti-inflammatory effect.

Pharmacokinetics

When applied topically, it is rapidly absorbed and converted into pantothenic acid, binding to plasma proteins (mainly beta-globulin and albumin).

Indications

Violations of skin integrity caused by mechanical, chemical, temperature factors, or after surgical interventions (burns of various origins (including sunburns); scratches, abrasions, wounds; bedsores; poorly healing skin grafts; aseptic postoperative wounds);
Inflammatory processes on the skin; dermatitis; boils; trophic ulcers of the lower extremities; care for the skin around tracheostomies, gastrostomies, and colostomies;
Treatment and prevention of the consequences of adverse environmental effects on the skin (cold, wind, dampness);
In children – diaper dermatitis, scratches and minor irritation after exposure to the sun, ultraviolet and X-ray radiation; treatment and prevention of diaper rash;
Cracks and inflammation of the nipples of the mammary glands in nursing mothers;
For the treatment and protection of dry skin as a source of neutral fats and dexpanthenol.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
L02	Cutaneous abscess, furuncle and carbuncle
L20.8	Other atopic dermatitis (neurodermatitis, eczema)
L22	Diaper dermatitis
L30.4	Erythematous intertrigo
L30.9	Dermatitis, unspecified
L55	Sunburn
L56.2	Photocontact dermatitis [berloque dermatitis]
L89	Decubitus ulcer and pressure area
L98.4	Chronic skin ulcer, not elsewhere classified
N64.0	Fissure and fistula of nipple
T14.0	Superficial injury of unspecified body region (including abrasion, bruise, contusion, hematoma, bite of nonvenomous insect)
T14.1	Open wound of unspecified body region
T30	Burns and corrosions of unspecified body region
Z58.8	Other problems related to physical environmental factors
Z93.0	Tracheostomy status
Z93.1	Gastrostomy status
Z93.3	Colostomy status
Z94.6	Presence of transplanted bone

ICD-11 code	Indication
1B75.0	Furuncle
1B75.1	Carbuncle
1B75.2	Furunculosis
1B75.3	Pyogenic skin abscess
9A06.70	Atopic eczema of the eyelids
EA40	Tropical phagedenic ulcer
EA80.0	Infantile atopic eczema
EA80.1	Childhood atopic eczema
EA80.2	Adult atopic eczema
EA80.Z	Atopic eczema, unspecified
EA85.20	Atopic hand eczema
EA85.2Z	Hand dermatitis, unspecified
EA85.3	Foot dermatitis
EA89	Generalized eczematous dermatitis of unspecified type
EA8Z	Dermatitis or eczema, unspecified
EF60	Ischemic ulceration of the skin
EH40.10	Diaper dermatitis
EH90.Z	Pressure ulcer of unspecified degree
EH92	Dermatoses provoked by friction or mechanical impact
EH92.1	Blister due to friction
EK02.20	Intertriginous dermatitis due to friction, sweating or contact with body fluids
EK20	Photoallergic reaction to fragrances or cosmetic products
EM0Z	Unspecified skin disorder
GB23.1	Fissure or fistula of nipple
ME60.2	Ulcerative skin lesion of unspecified nature
ND56.0	Superficial injury of unspecified body region
ND56.1	Open wound of unspecified body region
NE11	Burn of unspecified body region
QB61.0	Tracheostomy status
QB61.2	Gastrostomy status
QB61.4	Colostomy status
QB63.5	Presence of transplanted bone
QD70.Z	Problems related to the natural environment or anthropogenic changes in the environment, unspecified
QD7Z	Problems related to the environment, unspecified

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Ointment

The ointment is applied 2-4 times a day (more often if necessary) in a thin layer to the affected area of the skin, rubbing in gently.

If applied to an infected skin surface, it should first be treated with any antiseptic.

Nursing mothers should apply the ointment to the nipple surface after each breastfeeding.

For infants, the ointment is applied after each diaper change or water procedure.

Foam

Apply externally to the affected skin surface or for care and rub in gently. The frequency of application depends on the indications.

Adverse Reactions

Adverse effects develop extremely rarely. Mild allergic reactions are possible.

Contraindications

Hypersensitivity to any of the components of the drug.

Use in Pregnancy and Lactation

According to indications: cracks and inflammation of the nipples of the mammary glands in nursing mothers.

Pediatric Use

Used according to indications.

Special Precautions

Treatment of trophic ulcers and poorly healing skin grafts should be carried out under the supervision of the attending physician.

Do not apply to weeping wounds.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Dexpanthenol [Vertex, JSC (Russia)]
Ointment for external use 5%: tube 30 g

Marketing Authorization Holder

Vertex, JSC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: tube 30 g

Dosage Form, Packaging, and Composition

Ointment for external use 5% light yellow in color, homogeneous, with a characteristic smell of lanolin.

	1 g
Dexpanthenol	50 mg

Excipients: petrolatum, white petrolatum, liquid paraffin, isopropyl myristate, methylparahydroxybenzoate (nipagin), propylparahydroxybenzoate (nipazol), purified water.

30 g – aluminum tubes (1) – cardboard packs.

Dexpanthenol [West, LLC (Russia)]
Ointment for external use 5%: jars or tubes 25 g, 30 g, 40 g, 50 g, or 100 g

Marketing Authorization Holder

West, LLC (Russia)

Manufactured By

Samaramedprom, OJSC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: jars or tubes 25 g, 30 g, 40 g, 50 g, or 100 g

Dosage Form, Packaging, and Composition

Ointment for external use from white with a yellowish tint to light yellow, homogeneous, with a characteristic smell.

	100 g
Dexpanthenol	5 g

Excipients: petrolatum – 13 g, liquid paraffin – 20 g, lanolin – 25 g, cetearyl alcohol [cetyl alcohol 60%, stearyl alcohol 40%] – 3 g, white beeswax – 3 g, methylparahydroxybenzoate – 0.07 g, propylparahydroxybenzoate – 0.03 g, purified water – 30.9 g.

25 g – jars (1) – cardboard packs.
30 g – jars (1) – cardboard packs.
40 g – jars (1) – cardboard packs.
50 g – jars (1) – cardboard packs.
100 g – jars (1) – cardboard packs.
25 g – tubes (1) – cardboard packs.
30 g – tubes (1) – cardboard packs.
40 g – tubes (1) – cardboard packs.
50 g – tubes (1) – cardboard packs.
100 g – tubes (1) – cardboard packs.

Dexpanthenol [West, LLC (Russia)]
Foam for external use 5%: canister 58 g

Marketing Authorization Holder

West, LLC (Russia)

Manufactured By

Samaramedprom, OJSC (Russia)

Dosage Form

Dexpanthenol

Foam for external use 5%: canister 58 g

Dosage Form, Packaging, and Composition

Foam for external use white in color (formed upon release from the canister), with a faint characteristic odor.

	1 canister
Dexpanthenol	2.5 g

Excipients: cetostearyl alcohol emulsifying type A [cetostearyl alcohol 80%, sodium cetostearyl sulfate 7%], macrogol glyceryl cocoate, propylene glycol, methylparahydroxybenzoate, potassium dihydrogen phosphate, sodium phosphate dodecahydrate, purified water, tetrafluoroethane (propellant 134a).

58 g – aluminum aerosol canisters (1) with a continuous action valve and sprayer – cardboard packs.

Dexpanthenol [Vita Line, LLC (Russia)]
Ointment for external use 5%: tubes 15 g, 20 g, 25 g, 30 g, 35 g, 40 g, 50 g, 60 g, 70 g, 80 g, or 100 g

Marketing Authorization Holder

Vita Line, LLC (Russia)

Manufactured By

Tula Pharmaceutical Factory, LLC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: tubes 15 g, 20 g, 25 g, 30 g, 35 g, 40 g, 50 g, 60 g, 70 g, 80 g, or 100 g

Dosage Form, Packaging, and Composition

Ointment for external use homogeneous, from white with a yellowish tint to light yellow, with a specific odor.

	100 g
Dexpanthenol	5 g

Excipients: petrolatum – 27 g, liquid paraffin – 10 g, lanolin – 17 g, cholesterol – 0.5 g, isopropyl myristate – 3 g, methylparahydroxybenzoate – 0.07 g, propylparahydroxybenzoate – 0.03 g, purified water – 37.4 g.

15 g – tubes (1) – cardboard packs (1).
20 g – tubes (1) – cardboard packs (1).
25 g – tubes (1) – cardboard packs (1).
30 g – tubes (1) – cardboard packs (1).
35 g – tubes (1) – cardboard packs (1).
40 g – tubes (1) – cardboard packs (1).
50 g – tubes (1) – cardboard packs (1).
60 g – tubes (1) – cardboard packs (1).
70 g – tubes (1) – cardboard packs (1).
80 g – tubes (1) – cardboard packs (1).
100 g – tubes (1) – cardboard packs (1).

Dexpanthenol [Ivanovo Pharmaceutical Factory PJSC (Russia)]
Ointment for external use 5%: jars 25 g, 30 g, 40 g, 50 g, or 100 g; tubes 25 g, 30 g, 40 g, 50 g, or 100 g

Marketing Authorization Holder

Ivanovo Pharmaceutical Factory PJSC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: jars 25 g, 30 g, 40 g, 50 g, or 100 g; tubes 25 g, 30 g, 40 g, 50 g, or 100 g

Dosage Form, Packaging, and Composition

Ointment for external use homogeneous from white with a yellowish tint to light yellow with a characteristic odor.

	100 g
Dexpanthenol	5 g

Excipients: petrolatum, liquid paraffin (liquid petrolatum), lanolin, cetearyl alcohol (cetyl alcohol 60% and stearyl alcohol 40%), white beeswax, methylparahydroxybenzoate, propylparahydroxybenzoate, purified water.

25 g – jars (1) – cardboard packs.
30 g – jars (1) – cardboard packs.
40 g – jars (1) – cardboard packs.
50 g – jars (1) – cardboard packs.
100 g – jars (1) – cardboard packs.
25 g – aluminum tubes (1) – cardboard packs.
30 g – aluminum tubes (1) – cardboard packs.
40 g – aluminum tubes (1) – cardboard packs.
50 g – aluminum tubes (1) – cardboard packs.
100 g – aluminum tubes (1) – cardboard packs.

Dexpanthenol [Promomed Rus LLC (Russia)]
Ointment for external use 5%: tubes 25 g, 50 g, or 100 g

Marketing Authorization Holder

Promomed Rus LLC (Russia)

Manufactured By

Biokhimik, JSC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: tubes 25 g, 50 g, or 100 g

Dosage Form, Packaging, and Composition

Ointment for external use from white with a yellowish tint to light yellow, with a specific smell of lanolin.

	100 g
Dexpanthenol	5 g

Excipients: petrolatum – 38 g, liquid paraffin – 10 g, almond oil – 0.3 g, beeswax (white) – 2.7 g, anhydrous lanolin – 21 g, cetearyl alcohol [cetyl alcohol 60%, stearyl alcohol 40%] (Lanette 0) – 3 g, purified water – 20 g.

25 g – tubes made of combined material with caps (1) – cardboard packs.
50 g – tubes made of combined material with caps (1) – cardboard packs.
100 g – tubes made of combined material with caps (1) – cardboard packs.

Dexpanthenol [Tatkhimpharmpreparaty, JSC (Russia)]
Ointment for external use 5%: tubes 25 g or 30 g

Marketing Authorization Holder

Tatkhimpharmpreparaty, JSC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: tubes 25 g or 30 g

Dosage Form, Packaging, and Composition

Ointment for external use 5%	1 g
Dexpanthenol	50 mg

25 g – aluminum tubes (1) – cardboard packs.
30 g – aluminum tubes (1) – cardboard packs.

Dexpanthenol [Tula Pharmaceutical Factory, LLC (Russia)]
Ointment for external use 5%: jars 5 g, 10 g, 15 g, 20 g, 25 g, 30 g, 35 g, 40 g, 50 g, 60 g, 70 g, 80 g, 90 g, or 100 g; tubes 20 g, 25 g, 30 g, 35 g, 40 g, 50 g, 60 g, 70 g, 80 g, 90 g, or 100 g

Marketing Authorization Holder

Tula Pharmaceutical Factory, LLC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: jars 5 g, 10 g, 15 g, 20 g, 25 g, 30 g, 35 g, 40 g, 50 g, 60 g, 70 g, 80 g, 90 g, or 100 g; tubes 20 g, 25 g, 30 g, 35 g, 40 g, 50 g, 60 g, 70 g, 80 g, 90 g, or 100 g

Dosage Form, Packaging, and Composition

Ointment for external use from white with a yellowish tint to light yellow, homogeneous, with a specific odor.

	100 g
Dexpanthenol	5 g

5 g – jars (1) – cardboard packs.
10 g – jars (1) – cardboard packs.
15 g – jars (1) – cardboard packs.
20 g – jars (1) – cardboard packs.
25 g – jars (1) – cardboard packs.
30 g – jars (1) – cardboard packs.
35 g – jars (1) – cardboard packs.
40 g – jars (1) – cardboard packs.
50 g – jars (1) – cardboard packs.
60 g – jars (1) – cardboard packs.
70 g – jars (1) – cardboard packs.
80 g – jars (1) – cardboard packs.
90 g – jars (1) – cardboard packs.
100 g – jars (1) – cardboard packs.
20 g – tubes (1) – cardboard packs.
25 g – tubes (1) – cardboard packs.
30 g – tubes (1) – cardboard packs.
35 g – tubes (1) – cardboard packs.
40 g – tubes (1) – cardboard packs.
50 g – tubes (1) – cardboard packs.
60 g – tubes (1) – cardboard packs.
70 g – tubes (1) – cardboard packs.
80 g – tubes (1) – cardboard packs.
100 g – tubes (1) – cardboard packs.

Dexpanthenol [Usolye-Sibirskiy Chemical and Pharmaceutical Plant, JSC (Russia)]
Ointment for external use 5%: 25 g, 30 g, 40 g, 50 g, or 60 g

Marketing Authorization Holder

Usolye-Sibirskiy Chemical and Pharmaceutical Plant, JSC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: 25 g, 30 g, 40 g, 50 g, or 60 g

Dosage Form, Packaging, and Composition

Ointment for external use	100 g
Dexpanthenol	5 g

25 g – aluminum tubes (1) – cardboard packs.
25 g – jar (1) – cardboard packs.
30 g – aluminum tubes (1) – cardboard packs.
30 g – jar (1) – cardboard packs.
40 g – aluminum tubes (1) – cardboard packs.
50 g – aluminum tubes (1) – cardboard packs.
60 g – aluminum tubes (1) – cardboard packs.

Dexpanthenol [Formula-FR, LLC (Russia)]
Ointment for external use 5%: tubes 15, 20, 25, 30, 35, 40, 50, 60, 70, 80, 100 g.

Marketing Authorization Holder

Formula-FR, LLC (Russia)

Manufactured By

Tula Pharmaceutical Factory, LLC (Russia)

Dosage Form

Dexpanthenol

Ointment for external use 5%: tubes 15, 20, 25, 30, 35, 40, 50, 60, 70, 80, 100 g.

Dosage Form, Packaging, and Composition

Ointment for external use is homogeneous, from white with a yellowish tint to light yellow in color, with a characteristic odor.

	100 g
Dexpanthenol	5 g

Excipients: petrolatum – 27 g, liquid paraffin – 10 g, lanolin – 17 g, cholesterol – 0.5 g, isopropyl myristate – 3 g, methylparahydroxybenzoate (nipagin, methylparaben) – 0.07 g, propylparahydroxybenzoate (nipasol, propylparaben) – 0.03 g, water – 37.4 g.

Dexpanthenol Renewal [Obnovlenie Pfc, JSC (Russia)]
Ointment for external use 50 mg/g

Marketing Authorization Holder

Obnovlenie Pfc, JSC (Russia)

Dosage Form

Dexpanthenol Renewal

Ointment for external use 50 mg/g

Dosage Form, Packaging, and Composition

Ointment for external use

Dexpanthenol

50 mg/g

100 g – tubes – cardboard packs – Over-the-counter
25 g – tubes – cardboard packs – Over-the-counter
30 g – jars – cardboard packs – Over-the-counter
30 g – tubes – cardboard packs – Over-the-counter
50 g – jars – cardboard packs – Over-the-counter
50 g – tubes – cardboard packs – Over-the-counter

Dexpanthenol-Vertex [Vertex, JSC (Russia)]
Ointment for external use 5%: tubes 30 g, 50 g, or 100 g

Marketing Authorization Holder

Vertex, JSC (Russia)

Dosage Form

Dexpanthenol-Vertex

Ointment for external use 5%: tubes 30 g, 50 g, or 100 g

Dosage Form, Packaging, and Composition

Ointment for external use is light yellow in color, homogeneous, with a characteristic odor.

	1 g
Dexpanthenol	50 mg

Excipients: lanolin (anhydrous lanolin), white soft paraffin, liquid paraffin, glycerol (glycerin), stearyl alcohol, cetyl alcohol, sodium citrate dihydrate, citric acid monohydrate, methylparahydroxybenzoate (methylparaben), purified water.

30 g – aluminum tubes (1) – cardboard packs.
50 g – aluminum tubes (1) – cardboard packs.
100 g – aluminum tubes (1) – cardboard packs.

Medixlife (Author)

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