Diarex-Himalaya (Tablets) Instructions for Use

Marketing Authorization Holder

Himalaya Wellness Company (India)

ATC Code

A07XA (Other antidiarrheal drugs)

Dosage Form

Diarex-Himalaya

Tablets: 100 pcs.

Dosage Form, Packaging, and Composition

Tablets from light brown to brown in color with specks, uncoated, round, biconvex.

Excipients: crospovidone, colloidal silicon dioxide, sodium carboxymethylcellulose, magnesium stearate.

100 pcs. – plastic bottles (1) – cardboard packs.

Clinical-Pharmacological Group

Antidiarrheal phytopharmaceutical

Pharmacotherapeutic Group

Antidiarrheal agent

Pharmacological Action

The complex of biologically active substances of the plants that are part of the drug Diarex-Himalaya provides the drug with antidiarrheal, antimicrobial, antioxidant, antispasmodic and anti-inflammatory action.

The plants in the drug exhibit a wide spectrum of pharmacological activity.

Antimicrobial activity against E. coli — Aegle marmelos, Punica granatum, Tinospora cordifolia, Holarrhena antidysenterica; against S. typhi — Aegle marmelos, Holarrhena antidysenterica; against V. cholerae – Punica granatum, Aegle marmelos; inhibit the growth of Salmonella — Holarrhena antidysenterica, Aegle marmelos; growth of Shigella — Holarrhena antidysenterica.

Amebicidal action is exhibited by Holarrhena antidysenterica, Tinospora cordifolia, Aegle marmelos, Punica granatum.

Anthelmintic action is possessed by Punica granatum, Aegle marmelos, Cyperus rotundus.

Holarrhena antidysenterica, Aegle marmelos and Punica granatum have antidiarrheal properties due to their effect on the hypersecretory phase of acute and chronic infectious diarrhea.

Astringent action in diarrhea of various origins is provided by Punica granatum, Holarrhena antidysenterica.

Demulcent, adsorbent and protective properties — calcinated mollusk shell.

Antioxidant and cytoprotective action Tinospora cordifolia, Aegle marmelos, Punica granatum and Cyperus rotundus have a powerful antioxidant membrane-stabilizing effect.

Anti-inflammatory activity Aegle marmelos, Cyperus rotundus and Punica granatum help reduce the severity of gastrointestinal inflammation.

Tinospora cordifolia is known as an effective immunomodulatory agent with hepatoprotective and antiulcer action.

Antispasmodic and motility-normalizing action Aegle marmelos reduces stomach spasms and pain; Cyperus rotundus is effective for intestinal motility disorders. The drug does not disrupt the natural intestinal microflora.

The synergistic action of the components determines the effectiveness of the drug Diarex-Himalaya in acute and chronic diarrhea of various origins, irritable bowel syndrome and dysbiosis.

Indications

• Diarrhea of various origins: food, allergic, infectious (bacterial, protozoal, viral);
• Irritable bowel syndrome;
• Dysbiosis;
• The drug is used as part of complex therapy as an auxiliary treatment agent.

ICD codes

Dosage Regimen

Orally. Between meals.

Children from 6 to 14 years — 1 tab. 2 times/day.

Adults and children over 14 years — 2 tabs 2 times/day.

The duration of the treatment course for acute diarrhea is 2-7 days.

The duration of the therapy course for chronic diarrhea, irritable bowel syndrome, dysbiosis — from 2 to 6 weeks.

If necessary, after a 2-week break, the therapy course can be repeated.

In severe forms of diarrhea, the frequency and duration of administration can be increased.

Adverse Reactions

Allergic reactions are possible.

Contraindications

• Intestinal obstruction;
• Acute dysentery with stool containing blood and fever;
• Children under 6 years of age;
• Hypersensitivity to the drug components.

Use in Pregnancy and Lactation

It is not recommended to prescribe the drug to pregnant women. During lactation, the issue of discontinuing breastfeeding should be considered.

Pediatric Use

Contraindicated in children under 6 years of age.

Children from 6 to 14 years — 1 tab. 2 times/day.

Special Precautions

It is necessary to monitor for symptoms of water-electrolyte imbalance and take measures to eliminate them by replenishing lost fluid and electrolytes. If diarrhea symptoms do not disappear within three days of treatment, or the patient’s condition worsens, the drug should be discontinued and a physician, infectious disease specialist or gastroenterologist should be consulted.

Overdose

No overdose data available. In case of overdose, symptomatic treatment is applied.

Drug Interactions

The drug can be used with other medications used to relieve diarrhea syndrome.

The use of the drug in combination with antibiotics, antiviral agents and intestinal antiseptics increases the effectiveness of therapy and reduces the severity of side effects of chemotherapy.

Concomitant use with adsorbents, astringents and demulcents may lead to a decrease in the drug’s effectiveness, so at least 3 hours should pass between taking the drug and the adsorbent.

Storage Conditions

Store the drug in a dry place at a temperature from 10°C (50°F) to 30°C (86°F). Keep out of reach of children.

Shelf Life

Shelf life – 3 years.

Do not use after the expiration date.

Dispensing Status

The drug is dispensed by prescription.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.