Mastodon

Ferrovir® (Solution) Instructions for Use

ATC Code

J05AX (Other antiviral drugs)

Clinical-Pharmacological Group

Antiviral and immunomodulatory drug

Pharmacotherapeutic Group

Antiviral and immunostimulating agent

Pharmacological Action

Extract from sturgeon milk (purified and standardized mixture of nucleic acids) has an immunostimulating and antiviral effect. It activates antiviral, antifungal, and antimicrobial immunity. It exhibits antiviral activity against RNA- and DNA-containing viruses.

Course use as part of complex therapy for AIDS/HIV infection increases the level of CD4 lymphocytes in the blood, which persists for 1-1.5 months after the completion of the treatment course. Simultaneously, the viral load in the body decreases.

In recurrent herpetic infection, the duration of the relapse is reduced and a long-term remission occurs.

Use in patients with chronic hepatitis C contributes to a decrease in the replicative activity of the hepatitis C virus and transitions the process into a latent phase.

Pharmacokinetics

After intramuscular administration of the recommended dose, absorption is rapid. Tmax is 0.5 hours. T1/2 is 36 hours. After 24 hours, the concentration of the drug in the blood begins to decrease, associated with its distribution in organs and tissues.

With repeated administration of the drug every 24 hours for 5 days, a process of its accumulation in the blood and bone marrow is observed. After the fifth administration, the concentration of the drug in all organs and tissues decreases.

It is excreted (unchanged and in the form of metabolites) mainly by the kidneys (60%) and partially with feces (15%).

Indications

As part of combination therapy: HIV infection, AIDS; hepatitis C and recurrent herpetic infection in HIV-infected patients.

ICD codes

ICD-10 code Indication
B20.3 Human immunodeficiency virus [HIV] disease resulting in other viral infections
B24 Human immunodeficiency virus [HIV] disease, unspecified
ICD-11 code Indication
1C62.1 HIV disease, clinical stage 2, without mention of tuberculosis or malaria
1C62.Z Human immunodeficiency virus [HIV] disease without mention of associated disease or condition, clinical stage unspecified

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Solution

Intramuscularly (slowly, over 1-2 minutes) for adults with HIV infection or AIDS – 5 ml of a 1.5% injection solution (75 mg in terms of dry substance) 2 times/day for 14 days. If necessary, a repeat course of therapy may be prescribed after 1-1.5 months.

For herpes – 5 ml of a 1.5% solution (75 mg) intramuscularly 2 times/day for 10 days.

For hepatitis C – 5 ml of a 1.5% solution (75 mg) 2 times/day for 14 days. During the subsequent 14 days, the drug is administered at the same daily dose every other day.

Adverse Reactions

Rarely – short-term increase in body temperature (up to 38°C (100.4°F)), redness and pain at the injection site.

Contraindications

Hypersensitivity; pregnancy; lactation period; childhood.

Use in Pregnancy and Lactation

Contraindicated during pregnancy and lactation.

Pediatric Use

Contraindicated in childhood.

Special Precautions

To reduce pain, administer intramuscularly slowly, over 1-2 minutes.

The injection solution should be used completely immediately after opening the ampoule; storage of opened ampoules is not permitted.

Intravenous administration of the drug is not allowed!

Drug Interactions

Moderately enhances the effect of anticoagulants.

Storage Conditions

Store at 8°C (46°F) to 15°C (59°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Marketing Authorization Holder

Pharmpak, LLC (Russia)

Manufactured By

Fz Immunnoleks, LLC (Russia)

Dosage Form

Bottle Rx Icon Ferrovir® Solution for intramuscular injection 15 mg/1 ml: fl. 2 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for intramuscular injection transparent, yellow in color, without foreign inclusions.

1 ml 1 vial
Sodium deoxyribonucleate with iron complex 15 mg 30 mg

Excipients: water for injections.

2 ml – glass vials (10) – trays (1) – cardboard packs.

Marketing Authorization Holder

Pharmpak, LLC (Russia)

Manufactured By

Fz Immunnoleks, LLC (Russia)

Dosage Form

Bottle Rx Icon Ferrovir® Solution for intramuscular injection 15 mg/1 ml: fl. 5 ml 5 pcs.

Dosage Form, Packaging, and Composition

Solution for intramuscular injection in the form of a transparent, yellow liquid.

1 ml 1 vial (5 ml)
Complex of sodium deoxyribonucleate with iron 15.05 mg 75.24 mg

Excipients: water for injections – up to 5 ml.

5 ml – glass vials (5) – plastic contour packaging (trays) (1) – cardboard packs.

Table of Contents

→ TABLE OF CONTENTS