Gingium (Tablets) Instructions for Use

ATC Code

N06DX02 (Ginkgo biloba leaves)

Active Substance

Ginkgo biloba (BP British Pharmacopoeia)

Clinical-Pharmacological Group

Herbal preparation improving cerebral and peripheral circulation

Pharmacotherapeutic Group

Angioprotective agent of plant origin

Pharmacological Action

A herbal preparation. Its action is determined by the nature of its influence on metabolic processes in cells, the rheological properties of blood and microcirculation, as well as on the vasomotor reactions of large blood vessels.

It improves cerebral circulation and the supply of oxygen and glucose to the brain. It has a vasodilating effect and prevents platelet aggregation. It normalizes metabolic processes and has an antihypoxic effect on tissues.

It prevents lipid peroxidation and the formation of free radicals in cell membranes. It has a pronounced anti-edema effect at the level of the brain and in peripheral tissues. In various pathological conditions, it prevents an increase in the proteolytic activity of serum.

Indications

• Use in geriatric patients for the management of symptoms arising from cerebrovascular disorders.
• Treat cognitive deficits including disorders of attention and memory.
• Address impairments in mental activity and subjective feelings of fear.
• Alleviate dizziness, tinnitus, and sleep disorders.
• Manage a general state of malaise associated with cerebral circulatory insufficiency.

ICD codes

Dosage Regimen

Administer the tablets orally. The standard adult dosage is 40 mg taken three times daily.

Adhere strictly to the prescribed dosing schedule. Do not exceed the recommended daily intake. The duration of therapy is determined by the physician based on the patient’s clinical response and underlying condition.

Adverse Reactions

Monitor patients for potential adverse effects during treatment. Gastrointestinal disturbances, such as dyspepsia or nausea, may occur.

Some individuals may experience headaches. Be aware of the possibility of allergic skin reactions, including rash and pruritus. Discontinue use immediately if signs of a hypersensitivity reaction develop.

Contraindications

• Do not use in patients with known hypersensitivity to Ginkgo biloba or any component of the formulation.
• Contraindicated in conditions associated with an increased risk of bleeding, such as reduced blood clotting.
• Avoid use in patients with erosive gastritis or peptic ulcer disease in the acute phase.
• Do not use following acute cerebrovascular accidents or acute myocardial infarction.
• Contraindicated in cases of significant arterial hypotension.
• Use is prohibited during pregnancy and lactation.
• Not for use in children and adolescents under 18 years of age.

Use in Pregnancy and Lactation

Ginkgo biloba is contraindicated for use during pregnancy and during lactation (breastfeeding).

Pediatric Use

Contraindicated in children and adolescents under 18 years of age.

Special Precautions

Avoid the use of Ginkgo biloba preparations in the presence of risk factors for the development of intracranial hemorrhage.

Drug Interactions

Exercise extreme caution with concomitant use of drugs affecting hemostasis. Concurrent administration with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., clopidogrel), or NSAIDs including acetylsalicylic acid may potentiate the risk of bleeding.

There are specific reports of an increased risk of cerebral hemorrhage when combined with thrombolytic therapy. Closely monitor patients for signs of bleeding.

Overdose

In case of suspected overdose, immediately discontinue the medication and institute supportive measures. Symptoms of overdose may be an exaggeration of known adverse reactions.

Given the pharmacological profile, be vigilant for signs of bleeding diathesis or severe gastrointestinal discomfort. There is no specific antidote; treatment should be symptomatic and directed at the clinical presentation.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.