Glycyrrihizae syrup (Syrup) Instructions for Use

Instructions
Dosage forms

ATC Code

R05CA (Expectorants)

Active Substance

Liquorice (Ph.Eur. European Pharmacopoeia)

Clinical-Pharmacological Group

Herbal preparation with expectorant and anti-inflammatory effects

Pharmacotherapeutic Group

Drugs used for cough and colds; expectorants, excluding combinations with antitussives; expectorants

Pharmacological Action

It is a herbal medicinal product. Liquorice root contains glycyrrhizin (from 6 to 12%), glycyrrhizic acid and its salts, flavonoid glycosides (liquiritin, liquiritigenin, liquiritoside), isoflavonoids (formononetin, glabrene, glabridin, glabrol, 3-hydroxyglabrol, glycyrrhisoflavone), coumestan derivatives (glycyrol, isoglycyrol, licocoumarin), hydroxycoumarins (including herniarin, umbelliferone, glycycoumarin, licopyranocoumarin), steroids (sterols, including beta-sitosterol, sigmasterol), essential oils (in small amounts).

Glycyrrhizin stimulates the activity of the ciliated epithelium and enhances the secretory function of the mucous membranes of the upper respiratory tract, facilitating expectoration. It has an anti-ulcer and anti-inflammatory effect and reduces platelet aggregation.

Liquorice inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase in the kidneys, which leads to a decrease in the conversion of cortisol to cortisone. The mineralocorticoid activity of cortisol causes a decrease in serum potassium concentration and an increase in sodium content, leading to fluid retention in the body, weight gain, and arterial hypertension. Glycyrrhizic acid and its metabolites inhibit the peripheral metabolism of cortisol and cause a pseudoaldosterone-like effect.

Liquiritoside has an antispasmodic effect on smooth muscles.

Indications

As part of combination therapy for infectious and inflammatory diseases of the respiratory tract (mainly in the presence of poorly separable, thick and viscous secretion). As part of combination therapy for chronic inflammatory diseases of the gastrointestinal mucosa.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
J04	Acute laryngitis and tracheitis
J15	Bacterial pneumonia, not elsewhere classified
J20	Acute bronchitis
J37	Chronic laryngitis and laryngotracheitis
J42	Unspecified chronic bronchitis
K29	Gastritis and duodenitis
R09.3	Sputum

ICD-11 code	Indication
CA05	Acute laryngitis or tracheitis
CA0G	Chronic laryngitis or laryngotracheitis
CA20.1Z	Chronic bronchitis, unspecified
CA40.0Z	Bacterial pneumonia, unspecified
CA42.Z	Acute bronchitis, unspecified
DA42.Z	Gastritis, unspecified
DA51.Z	Duodenitis, unspecified
DA7Z	Diseases of stomach or duodenum, unspecified
MD10	Abnormal sputum

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Administer the syrup orally three times daily.

Adhere strictly to the age-specific dosing schedule.

For adults and children over 12 years, the dose is 15 ml.

For children from 6 to 12 years, the dose is 10 ml.

For children from 2 to 6 years, the dose is 5 ml.

Do not administer to children under 2 years of age.

Use a measuring cup or spoon for accurate dosing.

The standard treatment course is 7 to 10 days.

Do not exceed the recommended duration of use without medical supervision.

Consult a physician to determine the necessity of a repeated course.

To facilitate expectoration of thick sputum, ensure adequate intake of warm fluids.

Do not use concomitantly with antitussive drugs, such as those containing codeine.

Discontinue use and consult a physician if edema or increased blood pressure occurs.

Monitor for signs of hypokalemia, especially with prolonged use.

Adverse Reactions

Possible allergic reactions; with prolonged use of liquorice preparations – increased blood pressure, appearance of edema, disorders of the reproductive system.

Contraindications

Hypersensitivity to liquorice preparations, chronic hepatitis, liver diseases with cholestasis, liver cirrhosis, exacerbation of gastric and duodenal ulcer, severe renal failure, diabetes mellitus, cardiac arrhythmias, arterial hypertension, hypokalemia; pregnancy, breastfeeding period; childhood – depending on the dosage form.

Use in Pregnancy and Lactation

Liquorice preparations are contraindicated for use during pregnancy and lactation (breastfeeding).

Use in Hepatic Impairment

Contraindicated in chronic hepatitis, liver diseases with cholestasis, liver cirrhosis.

Use in Renal Impairment

Contraindicated in severe renal failure.

Pediatric Use

It can be used in children of appropriate age categories strictly according to indications, in recommended doses and dosage forms. It is necessary to strictly follow the instructions in the instructions for liquorice preparations regarding contraindications for the use of specific dosage forms of liquorice in children of different ages.

Special Precautions

Should not be used simultaneously with drugs containing codeine and other antitussive medicinal products, as this makes it difficult to cough up liquefied sputum.

Drug Interactions

Concomitant use of liquorice with thiazide diuretics is not recommended due to the risk of hypokalemia.

Hypokalemia caused by prolonged use of liquorice may potentiate the toxic effect of cardiac glycosides.

With simultaneous use of liquorice and corticosteroids, an increase in the T_1/2 of cortisol is possible.

Storage Conditions

Store at 15°C (59°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Glycyrrihizae syrup [Altayvitamins, JSC (Russia)]
Syrup 4 g/100 g: bottle.

Marketing Authorization Holder

Altayvitamins, JSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle.

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of liquorice roots (liquorice roots and Ural liquorice roots with underground shoots)	4 g

100 g – dark glass bottles (1) – cardboard packs.
100 g – bottles.

Glycyrrihizae syrup [Begrif, LLC (Russia)]
Syrup 4 g/100 g: bottle 50 or 100 g.

Marketing Authorization Holder

Begrif, LLC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle 50 or 100 g.

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of liquorice roots (liquorice roots and Ural liquorice roots with underground shoots)	4 g

100 g – dark glass bottles (1) – cardboard packs.
50 g – dark glass bottles (1) – cardboard packs.
100 g – bottles (1) – cardboard packs.

Glycyrrihizae syrup [West, LLC (Russia)]
Syrup 4 g/100 g: bottle.

Marketing Authorization Holder

West, LLC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle.

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of liquorice roots (liquorice roots and Ural liquorice roots with underground shoots)	4 g

100 g – dark glass bottles (1) – cardboard packs.

Glycyrrihizae syrup [Vifitech, CJSC (Russia)]
Syrup 4 g/100 g: bottles or jars

Marketing Authorization Holder

Vifitech, CJSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottles or jars

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of liquorice roots (liquorice roots and Ural liquorice roots with underground shoots)	4 g

100 g – dark glass bottles (1) – cardboard packs.
100 g – dark glass jars (1) – cardboard packs.

Glycyrrihizae syrup [Geo Organics, LLC (Russia)]
Syrup: bottle

Marketing Authorization Holder

Geo Organics, LLC (Russia)

Manufactured By

Flora Kavkaza, JSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup: bottle

Dosage Form, Packaging, and Composition

Syrup in the form of a thick brown liquid, with a characteristic odor.

	1000 g
Thick extract of liquorice root*	40 g

* with a content of glycyrrhizic acid in terms of glycyram of at least 14%, DER: 3:1.

Excipients : sucrose, ethanol 96% (ethyl alcohol), purified water.

100 g – bottles (1) – cardboard packs.

Glycyrrihizae syrup [Genel RD, LLC (Russia)]
Syrup 4 g/100 g: bottle, dropper bottle or jar

Marketing Authorization Holder

Genel RD, LLC (Russia)

Manufactured By

Samaramedprom, OJSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle, dropper bottle or jar

Dosage Form, Packaging, and Composition

Syrup in the form of a thick brown liquid, with a characteristic odor.

	100 g
Thick extract of liquorice roots	4 g

Excipients : sugar syrup (sucrose or white sugar, purified water) – 86 g, ethanol (ethyl alcohol) 95% – 8.7 g, purified water – up to 100 g.

100 g – dark glass bottles (1).
100 g – dark glass bottles (1) – cardboard packs.
100 g – dark glass dropper bottles (1).
100 g – dark glass dropper bottles (1) – cardboard packs.
100 g – jars (1).
100 g – jars (1) – cardboard packs.

Glycyrrihizae syrup [Ivanovo Pharmaceutical Factory PJSC (Russia)]
Syrup 4 g/100 g: bottle.

Marketing Authorization Holder

Ivanovo Pharmaceutical Factory PJSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle.

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of liquorice roots (liquorice roots and Ural liquorice roots with underground shoots)	4 g

100 g – bottles (1) – cardboard packs.

Glycyrrihizae syrup [Kemerovo Pharmaceutical Factory JSC (Russia)]
Syrup 4 g/100 g: bottle.

Marketing Authorization Holder

Kemerovo Pharmaceutical Factory JSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle.

Dosage Form, Packaging, and Composition

Syrup in the form of a thick brown liquid, with a characteristic odor.

	100 g
Thick extract of liquorice root	4 g
With a content of glycyrrhizic acid	16 %

Excipients : ethanol (ethyl alcohol) 90 %, sucrose 55.04 g, purified water up to 100 g.

100 g – dark glass bottles (1) – cardboard packs.

Glycyrrihizae syrup [Kirov Pharmaceutical Factory, SUE (Russia)]
Syrup 4 g/100 g: bottle.

Marketing Authorization Holder

Kirov Pharmaceutical Factory, SUE (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle.

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of liquorice roots (liquorice roots and Ural liquorice roots with underground shoots)	4 g

100 g – dark glass bottles (1) – cardboard packs.

Glycyrrihizae syrup [Tatkhimpharmpreparaty, JSC (Russia)]
Syrup 4 g/100 g: bottle.

Marketing Authorization Holder

Tatkhimpharmpreparaty, JSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle.

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of liquorice roots (liquorice roots and Ural liquorice roots with underground shoots)	4 g

100 g – dark glass bottles (1) – cardboard packs.

Glycyrrihizae syrup [Tver Pharmaceutical Factory, PJSC (Russia)]
Syrup 4 g/100 g: bottle 40 g, 50 g or 100 g

Marketing Authorization Holder

Tver Pharmaceutical Factory, PJSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle 40 g, 50 g or 100 g

Dosage Form, Packaging, and Composition

Syrup in the form of a thick brown liquid, with a characteristic odor.

	100 g
Liquorice thick extract	4 g

Excipients : sugar syrup (sucrose, water) – 86 g, alcohol (ethanol) 90% – 10 g.

40 g – orange glass bottles (1) – cardboard packs.
50 g – orange glass bottles (1) – cardboard packs.
100 g – orange glass bottles (1) – cardboard packs.

Glycyrrihizae syrup [Tula Pharmaceutical Factory, LLC (Russia)]
Syrup 4 g/100 g: 50 or 100 g bottle

Marketing Authorization Holder

Tula Pharmaceutical Factory, LLC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: 50 or 100 g bottle

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of liquorice roots (liquorice roots and Ural liquorice roots with underground shoots)	4 g

Excipients : sucrose 55.04 g, ethanol 95% 9.27 g, purified water 31.69 g.

50 g – dark glass bottles (1) – cardboard packs.
100 g – dark glass bottles (1) – cardboard packs.
50 g – polyethylene terephthalate bottles (1) – cardboard packs.
100 g – polyethylene terephthalate bottles (1) – cardboard packs.

Glycyrrihizae syrup [Fk Crocus-Pharm, LLC (Russia)]
Syrup 4 g/100 g: 100 g bottle

Marketing Authorization Holder

Fk Crocus-Pharm, LLC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: 100 g bottle

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of licorice roots (roots with underground shoots of Glycyrrhiza glabra and Glycyrrhiza uralensis)	4 g

100 g – orange glass bottles (1) – cardboard packs.

Glycyrrihizae syrup [Flora Kavkaza, JSC (Russia)]
Syrup: 100 g bottles 1 or 40 pcs. or 20 kg jars

Marketing Authorization Holder

Flora Kavkaza, JSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup: 100 g bottles 1 or 40 pcs. or 20 kg jars

Dosage Form, Packaging, and Composition

Syrup in the form of a thick brown liquid with a characteristic odor.

	100 g
Extract of Glycyrrhiza glabra roots	4 g

Excipients: sugar syrup – 86 g, ethanol 95% (ethyl alcohol) – 9.2 g, purified water – 0.8 g.

100 g – bottles (1) – cardboard packs.

* Composition of the syrup: sucrose – 64 g, purified water – 36 g.

Glycyrrihizae syrup [Ecolab, JSC (Russia)]
Syrup: bottle 100 g

Marketing Authorization Holder

Ecolab, JSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup: bottle 100 g

Dosage Form, Packaging, and Composition

Syrup in the form of a brown liquid, with a specific odor.

	100 g
Licorice root extract (thick licorice extract)	4 g

Excipients: sucrose (sugar) – 55 g, ethanol 90% (ethyl alcohol) – 10 g, purified water – 31 g.

100 g – dark glass bottles (1) – cardboard packs.

Glycyrrihizae syrup [Yaroslavl Pharmaceutical Factory, CJSC (Russia)]
Syrup 4 g/100 g: bottle 60 g 1 or 40 pcs., 100 g 1 or 20 pcs, 125 g 1 or 20 pcs.

Marketing Authorization Holder

Yaroslavl Pharmaceutical Factory, CJSC (Russia)

Dosage Form

Glycyrrihizae syrup

Syrup 4 g/100 g: bottle 60 g 1 or 40 pcs., 100 g 1 or 20 pcs, 125 g 1 or 20 pcs.

Dosage Form, Packaging, and Composition

Syrup	100 g
Extract of licorice roots (roots with underground shoots of Glycyrrhiza glabra and Glycyrrhiza uralensis)	4 g

60 g – dark glass bottles (1) – cardboard packs.
100 g – dark glass bottles (1) – cardboard packs.
125 g – dark glass bottles (1) – cardboard packs.
60 g – dark glass bottles (40) – cardboard boxes.
100 g – dark glass bottles (20) – cardboard boxes.
125 g – dark glass bottles (20) – cardboard boxes.

Glycyrrihizae radicis syrup [Moscow Pharmaceutical Factory CJS (Russia)]
Syrup 4 g/100 g: bottle.