Grippoflu^® Immunitet (Powder) Instructions for Use

Marketing Authorization Holder

Marbiopharm, JSC (Russia)

Dosage Form

Grippoflu® Immunitet

Powder for oral solution (orange flavored): sachets 2 g 20 pcs.

Dosage Form, Packaging, and Product Composition

Powder for preparation of oral solution with orange flavor.

Composition (1 sachet) sorbitol (E420), rosehip extract, "Orange" flavor, echinacea extract, citric acid (E330), ascorbic acid, ginseng extract, sodium citrate (E331), fructose, Zinc (as sulfate), sodium saccharin (E954), talc (anti-caking agent).

* TR TS 022/2011 "Food products regarding their labeling".

2 g – sachets (20) – cardboard packs.

Therapeutic Category

Dietary supplement – source of vitamins and trace elements

Properties

Dietary supplement to food.

The action of a specific product is determined by the biological properties of the active substances included in its composition.

Not all of the active substances listed below may be included in the composition of the dietary supplement used.

Polyphenolic compounds are natural organic substances in the molecule of which there are 2 or more phenolic groups. They are antioxidants. They can have a bactericidal effect, improve the state of the immune system, and reduce capillary permeability. Polyphenolic compounds include flavonoids, tannin; lignans.

Flavonoids are widespread in the plant world. They have pronounced antioxidant properties; various flavonoids have antiallergic, anti-inflammatory, antiviral, antibacterial properties and other types of biological activity. In plants, flavonoids are found in the form of flavonoglycosides and in free form.

The main classes of flavonoids include flavanones (hesperidin, diosmin, naringin), dihydrochalcones, chalcones, flavans (catechin, anthocyanidins), flavanonols (dihydroflavonols), flavonols (quercetin, dihydroquercetin, rutin), flavones (apigenin, luteolin), and isoflavonoids.

Catechins are compounds of plant origin. Catechin and its diastereomer, epicatechin, are widespread in nature. They have high biological activity: they regulate capillary permeability. Catechins are found in many plants and plant products and are strong antioxidants. They have a number of beneficial properties, including promoting the strengthening of the capillary wall, more efficient use of ascorbic acid by the body; delaying the development of degenerative bone diseases; promoting skin improvement; exhibiting antibacterial and anti-inflammatory properties; and can suppress Helicobacter pylori without affecting the beneficial microorganisms of the gut biota.

The antioxidant properties of catechins are several times stronger than those of vitamins C and E.

Tannins (tannic acids) are organic substances of natural origin. The highest amount of tannins is found in oak bark. They give an astringent taste to fruits and wines and are found in tea. The difference between tannins and other polyphenolic compounds is their ability to form strong hydrogen bonds with proteins. They have astringent, antibacterial, hemostatic, and anti-inflammatory properties.

Anthocyanidins are present in plants in the form of glycosides (anthocyanins). They give plant tissues a variety of colors – from pink to black-violet.

Hesperidin – a bioflavonoid. Reduces venous distensibility, increases their tone, which helps reduce venous congestion; reduces capillary permeability and increases their resistance, improves microcirculation and lymph flow.

Lignans are found in the greatest quantity in Chinese magnolia vine. Schisandra lignans – schisandrins, have tonic activity. Eleutherosides – eleutherococcus lignans – increase the synthesis of endorphins, which cause the breakdown of fats and their release into the blood. They activate carbohydrate metabolism, preventing their conversion into fats.

Rutoside (rutin) is an angioprotector. It belongs to the vitamin P group. By eliminating increased capillary permeability, it strengthens the vascular wall and reduces its swelling and inflammation. It has an antiplatelet effect, which helps improve microcirculation. It slows down the development of diabetic retinopathy. When applied topically, it also has a cooling and soothing effect.

Vitamin C (ascorbic acid) ensures the synthesis of collagen; participates in the formation and maintenance of the structure and function of cartilage, bones, teeth; affects the formation of hemoglobin and the maturation of red blood cells.

Vitamin E (α-tocopherol acetate) has antioxidant properties, maintains the stability of red blood cells, prevents hemolysis; has a positive effect on the functions of the gonads, nervous and muscle tissue.

Carotenoids (betacarotene, lutein, lycopene) are natural organic pigments synthesized by bacteria, fungi, algae, higher plants, and coral polyps; colored yellow, orange, or red. Betacarotene is a precursor of vitamin A. It has an antioxidant effect and has the ability to inactivate free radicals under hypoxic conditions. It has an immunomodulatory effect. Increases the body’s resistance to infections.

Caffeine – increases mental and physical performance, stimulates mental activity, motor activity, shortens reaction time, temporarily reduces fatigue and drowsiness.

Organic acids, including hydroxycitric acid, a group of hydroxycinnamic acids are found mainly in plant products: in fruits, berries, some vegetables and their processed products. It is believed that organic acids promote the acceleration of physiological processes.

Panaxosides are triterpene glycosides, the main source of which is ginseng root. They increase the body’s resistance to harmful physical, chemical, and biological factors. Their immunostimulating effect is expressed in the stimulation of antibody production, accompanied by an increase in the amount of total protein and gamma globulins in the blood. Panaxosides stimulate hematopoiesis, almost doubling the biosynthesis of nucleic acids, proteins, and fats in the bone marrow. They contribute to the normalization of the work of organs and various functions of the body.

Escin is a triterpene glycoside (saponin) from the fruits (seeds) of horse chestnut. It has pronounced capillary-protective activity and has an anti-exudative effect.

Salidroside is a phenolic glycoside, found in significant quantities in the roots and rhizome of Rhodiola rosea and Rhodiola quadrifida, in willow bark; has a stimulating and adaptogenic effect.

Arbutin is a phenolic glycoside, which in the human body breaks down into hydroquinone and glucose. It has pronounced antiseptic properties. It is found in many plants, including wintergreen, lingonberry, bearberry, mulberry, bergenia, and Caucasian blueberry. The active compound has a significant antiseptic effect on the urinary tract.

Scope of Application

The scope of application corresponds to the recommendations for the specific product used.

ICD codes

Dosage Regimen

Used in accordance with the recommendations for the specific product used.

Side Effects

Possible allergic reactions.

Contraindications

Hypersensitivity to the substances included in the product and to the plants that are their sources.

Use During Pregnancy and Breastfeeding

During pregnancy and breastfeeding, only products intended for pregnant women and nursing mothers should be used.

Special Instructions

Not a medicinal product.

Consult a doctor before using the product.

Do not exceed the recommended dose of the product used.

In children, only dietary supplements intended for the corresponding age group should be used.

Drug Interactions

Concomitant use with other products or medicinal products containing components of the product used is not recommended to avoid overdose.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.