Khitahept (Tablets) Instructions for Use

Marketing Authorization Holder

Obnovlenie Pfc, JSC (Russia)

ATC Code

A05AX (Other drugs for the treatment of biliary tract diseases)

Active Substance

Cynara (BAN)

Dosage Form

Khitahept

Film-coated tablets, 200 mg

Dosage Form, Packaging, and Composition

Film-coated tablets

* equivalent to 1.6-2 g of Cynara scolymus (artichoke) leaves.
** corresponding to a chlorogenic acid content of 0.5 mg-5 mg.

Extraction solvent water.

10 pcs. – blister packs (12 pcs.) – cardboard packs (120 pcs.) – Over-the-counter
10 pcs. – blister packs (18 pcs.) – cardboard packs (180 pcs.) – Over-the-counter
10 pcs. – blister packs (3 pcs.) – cardboard packs (30 pcs.) – Over-the-counter
10 pcs. – blister packs (6 pcs.) – cardboard packs (60 pcs.) – Over-the-counter
10 pcs. – blister packs (9 pcs.) – cardboard packs (90 pcs.) – Over-the-counter
120 pcs. – jars – cardboard packs (120 pcs.) – Over-the-counter
15 pcs. – blister packs (12 pcs.) – cardboard packs (180 pcs.) – Over-the-counter
15 pcs. – blister packs (2 pcs.) – cardboard packs (30 pcs.) – Over-the-counter
15 pcs. – blister packs (4 pcs.) – cardboard packs (60 pcs.) – Over-the-counter
15 pcs. – blister packs (6 pcs.) – cardboard packs (90 pcs.) – Over-the-counter
15 pcs. – blister packs (8 pcs.) – cardboard packs (120 pcs.) – Over-the-counter
180 pcs. – jars – cardboard packs (180 pcs.) – Over-the-counter
20 pcs. – blister packs (3 pcs.) – cardboard packs (60 pcs.) – Over-the-counter
20 pcs. – blister packs (6 pcs.) – cardboard packs (120 pcs.) – Over-the-counter
20 pcs. – blister packs (9 pcs.) – cardboard packs (180 pcs.) – Over-the-counter
30 pcs. – blister packs – cardboard packs (30 pcs.) – Over-the-counter
30 pcs. – blister packs (2 pcs.) – cardboard packs (60 pcs.) – Over-the-counter
30 pcs. – blister packs (3 pcs.) – cardboard packs (90 pcs.) – Over-the-counter
30 pcs. – blister packs (4 pcs.) – cardboard packs (120 pcs.) – Over-the-counter
30 pcs. – blister packs (6 pcs.) – cardboard packs (180 pcs.) – Over-the-counter
90 pcs. – jars – cardboard packs (90 pcs.) – Over-the-counter

Clinical-Pharmacological Group

Herbal preparation with choleretic and diuretic effect

Pharmacotherapeutic Group

Means for the treatment of diseases of the liver and biliary tract; agents for the treatment of diseases of the biliary tract; other agents for the treatment of diseases of the biliary tract

Pharmacological Action

A herbal preparation. The phenolic compound cynarin, in combination with phenolic acids (caffeic, chlorogenic, neochlorogenic, cryptochlorogenic), exerts a choleretic and hepatoprotective effect.

It increases the excretion of urea, toxins (including nitro compounds, alkaloids), and heavy metal salts from the body. It helps to reduce the cholesterol content in the blood.

The ascorbic acid, carotene, vitamins B₁ and B₂, rutin, and inulin contained in artichoke contribute to the normalization of metabolic processes.

Indications

As an adjunctive agent for biliary dyskinesia of the hypokinetic type, cholecystitis, chronic hepatitis, anorexia, chronic intoxications (with hepatotoxic substances, nitro compounds, alkaloids, heavy metal salts), chronic renal failure, urolithiasis, uraturia, atherosclerosis, obesity.

ICD codes

Dosage Regimen

Administer the tablets orally. Swallow whole with a sufficient amount of liquid. Do not chew.

The standard adult dosage is one tablet (200 mg) taken three to four times daily. Adhere to this regimen unless otherwise directed by a physician.

Take the tablets before meals. This timing supports the physiological process of digestion and enhances the choleretic effect.

The duration of treatment is determined by the treating physician based on the underlying condition and clinical response. For chronic conditions, long-term use may be necessary.

For specific indications, adjust the regimen as follows: for biliary dyskinesia and chronic cholecystitis, use as part of a comprehensive therapeutic plan; for chronic intoxications, utilize the standard dosage to support detoxification processes.

Do not exceed the recommended daily dose. In case of a missed dose, take it as soon as remembered if it is not almost time for the next dose. Do not double the dose to catch up.

Discontinue use and consult a physician immediately if severe adverse reactions occur or if symptoms of the underlying condition worsen.

Adverse Reactions

Allergic reactions skin manifestations.

From the digestive system with prolonged use in high doses – diarrhea.

Contraindications

Acute diseases of the liver, biliary tract, kidneys, urinary tract, gastrointestinal tract; large stones in the biliary and urinary tracts; biliary dyskinesia of the hyperkinetic type; hypersensitivity to artichoke.

Use in Pregnancy and Lactation

Data on the safety of artichoke use during pregnancy and lactation are not available.

Use in Hepatic Impairment

Contraindicated in acute liver diseases.

Use in Renal Impairment

Contraindicated in acute kidney diseases.

Pediatric Use

Use in dosage forms intended for this category of patients.

Special Precautions

At the beginning of treatment, in some cases, an increase in blood cholesterol levels is possible, then this indicator normalizes and even decreases.

In children, use in dosage forms intended for this category of patients.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.