Krashaemodes 8000 (Solution) Instructions for Use

Marketing Authorization Holder

Kraspharma, PJSC (Russia)

ATC Code

B05AA (Blood substitutes and plasma preparations)

Dosage Form

Krashaemodes 8000

Infusion solution: 100 ml, 200 ml or 400 ml bottle 1 pc.

Dosage Form, Packaging, and Composition

100 ml – bottles (1) – cardboard packs.
200 ml – bottles (1) – cardboard packs.
400 ml – bottles (1) – cardboard packs.

Clinical-Pharmacological Group

Drug with detoxifying action for parenteral use

Pharmacotherapeutic Group

Detoxifying agent

Pharmacological Action

The action of the combination is due to the ability of low molecular weight polyvinylpyrrolidone to bind toxins circulating in the blood and rapidly remove them from the body. It most fully binds toxins circulating in the blood of patients with dysentery, salmonellosis, and food intoxications. In burn disease, toxins formed during the first 4-5 days of the disease are almost completely inactivated; toxins formed at later stages are neutralized significantly weaker.

Toxins formed in the body of patients with acute radiation sickness are not bound, although their elimination from the body may be accelerated.

It helps eliminate erythrocyte stasis in the capillaries, which develops during intoxication of any origin, leading to improved microcirculation. It enhances renal blood flow, increases glomerular filtration, and increases diuresis.

Pharmacokinetics

It is not metabolized in the body. It is rapidly excreted by the kidneys, 80% within 4 hours, and completely within 12-24 hours.

Indications

Shock (post-traumatic, postoperative, burn, hemorrhagic); intoxication (toxic diseases of the gastrointestinal tract, including dysentery, dyspepsia, salmonellosis; burn disease, radiation sickness and hemolytic disease, peritonitis, intestinal obstruction, thyrotoxicosis, liver diseases, sepsis, pneumonia; acute phase of myocardial infarction); toxemia of newborns; preeclampsia.

ICD codes

Dosage Regimen

Administer intravenously by drip at a rate of 40-80 drops per minute.

Use an infusion set with an in-line filter and a polymer connection needle.

Determine the total dose based on the patient’s age and the severity of intoxication.

For adults, the typical single dose is 100 ml to 400 ml.

For pediatric patients, calculate the dose individually per body weight.

In cases of severe shock or profound intoxication, repeat infusions as clinically required.

Adjust the infusion rate to avoid a rapid drop in blood pressure or respiratory distress.

Do not exceed the recommended infusion speed.

Monitor blood pressure, heart rate, and respiratory function continuously during administration.

Discontinue the infusion immediately if signs of a hypersensitivity reaction occur.

The total daily volume and frequency of administration are determined by the treating physician.

Adverse Reactions

Possible decrease in blood pressure, tachycardia, difficulty breathing (with rapid administration), allergic reactions of varying severity (up to the development of anaphylactic shock); infection at the injection site, thrombosis or phlebitis spreading from the infusion site.

Contraindications

Intracranial hypertension; hemorrhagic stroke; condition after traumatic brain injury; chronic heart failure stage IIb-III; respiratory failure; severe allergic reactions; thromboembolism; oliguria, anuria, acute nephritis; bronchial asthma; phlebothrombosis; hypersensitivity to the components of the combination.

Use in Pregnancy and Lactation

The possibility of use depends on the dosage form used.

Use in Renal Impairment

Contraindicated in acute nephritis.

Pediatric Use

Use is possible according to the dosage regimen.

Special Precautions

During treatment, monitoring of blood pressure and the patient’s condition is necessary.

Drug Interactions

For extensive burns, it is combined with the administration of plasma, albumin, gamma globulin.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.