Mannitol (Solution) Instructions for Use

Instructions
Dosage forms

ATC Code

B05BC01 (Mannitol)

Active Substance

Mannitol (BP British Pharmacopoeia)

Clinical-Pharmacological Group

Osmotic diuretic

Pharmacotherapeutic Group

Blood substitutes and perfusion solutions; solutions for intravenous administration; solutions with osmodiuretic action

Pharmacological Action

Osmotic diuretic. By increasing plasma osmotic pressure and filtration without subsequent tubular reabsorption, it leads to water retention in the tubules and an increase in urine volume.

By increasing plasma osmolarity, it causes fluid movement from tissues (in particular, the eyeball, brain) into the vascular bed. It causes a pronounced diuretic effect, which is characterized by the excretion of a large amount of osmotically free water, as well as sodium and chloride, without significant excretion of potassium.

It causes an increase in circulating blood volume.

Pharmacokinetics

After IV administration, the V_d of mannitol corresponds to the volume of extracellular fluid. Mannitol may undergo minor metabolism in the liver to form glycogen.

Mannitol excretion is regulated by glomerular filtration without significant tubular reabsorption. T_1/2 is about 100 min. It is excreted by the kidneys; after IV administration of a 100 g dose, 80% is detected in urine within 3 hours.

In renal failure, T_1/2 may increase to 36 hours.

Indications

Cerebral edema. Intracranial hypertension. Status epilepticus. Intraocular hypertension, acute attack of glaucoma.

Oliguria in acute renal failure. For determining the glomerular filtration rate in acute oliguria.

Acute hepatic failure. Acute hepatic failure in patients with preserved renal filtration capacity and other conditions requiring increased diuresis.

Poisoning with barbiturates, salicylates, bromides, lithium preparations, forced diuresis in other poisonings.

Post-transfusion complications after administration of incompatible blood.

For the prevention of hemolysis and hemoglobinemia during transurethral resection of the prostate or during surgical procedures such as cardiopulmonary bypass, during operations with extracorporeal circulation.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
G41	Status epilepticus
G93.2	Benign intracranial hypertension
G93.6	Cerebral edema
H40.0	Glaucoma suspect (ocular hypertension)
H40.1	Primary open-angle glaucoma
H40.2	Primary angle-closure glaucoma
K72	Hepatic failure, not elsewhere classified (including hepatic coma, hepatic encephalopathy)
N17	Acute renal failure
R34	Anuria and oliguria
T39.0	Salicylates
T42.3	Barbiturate poisoning
T50.9	Other and unspecified drugs, medicaments and biological substances
T80.3	Reactions to AB0 incompatibility
T80.4	Reactions to Rh incompatibility
T88.8	Other specified complications of surgical and medical care, not elsewhere classified

ICD-11 code	Indication
8A66.Z	Status epilepticus, unspecified
8D60.1	Cerebral edema
8D60.Z	Increased intracranial pressure, unspecified
9C60	Glaucoma suspect
9C61.0Z	Primary open-angle glaucoma, unspecified
9C61.1Z	Primary angle-closure glaucoma, unspecified
DB91.Z	Unspecified acute or subacute liver failure
DB99.7	Hepatic failure, not specified as acute or chronic
DB99.8	Chronic hepatic failure
DB9Z	Liver diseases, unspecified
GB60.Z	Acute renal failure, unspecified stage
GB6Z	Renal failure, unspecified
MF51	Anuria or oliguria
NE60	Poisoning by drugs, medicaments or biological substances, not elsewhere classified
NE80.1	Reaction to AB0 incompatibility
NE80.2	Reaction to Rh incompatibility
NE8Z	Injury or harm caused as a result of surgical or therapeutic interventions, not elsewhere classified, unspecified

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Solution

Mannitol is administered IV or by inhalation in appropriate dosage forms.

For IV administration (slow bolus or drip), the prophylactic dose is 500 mg/kg body weight, the therapeutic dose is 1-1.5 g/kg. The daily dose should not exceed 140-180 g. For operations with extracorporeal circulation, it is administered at a dose of 20-40 g immediately before surgery.

Patients with oliguria should first be given an IV test dose of mannitol (200 mg/kg) over 3-5 minutes. If no increase in urine output to 30-50 ml/hour is observed within 2-3 hours after this, further administration of mannitol should be avoided.

Adverse Reactions

Metabolism: disorders of water-electrolyte balance (increased circulating blood volume, dilutional hyponatremia, hyperkalemia) and their manifestations (muscle weakness, cramps, dry mouth, thirst, impaired consciousness).

Other: tachycardia, chest pain, thrombophlebitis, skin rash.

Contraindications

Chronic renal failure, impaired renal filtration function, left ventricular failure (especially accompanied by pulmonary edema), hemorrhagic stroke, subarachnoid hemorrhage (except for bleeding during craniotomy), severe forms of dehydration, hyponatremia, hypochloremia, hypokalemia, hypersensitivity to mannitol.

Use in Pregnancy and Lactation

Adequate and strictly controlled studies in humans have not been conducted.

The use of mannitol during pregnancy and lactation is possible in cases where the intended benefit to the mother outweighs the potential risk to the fetus or breastfed infant.

Use in Hepatic Impairment

Used according to indications.

Use in Renal Impairment

Contraindicated in chronic renal failure, impaired renal filtration function.

Use with caution in patients with renal impairment.

Pediatric Use

It is not recommended to use Mannitol by inhalation in children under 6 years of age due to insufficient data on safety and efficacy.

Geriatric Use

Use with caution to avoid the risk of exacerbation of chronic diseases.

Special Precautions

Use with caution in patients with severe forms of chronic heart failure, hypovolemia, renal impairment.

If symptoms such as headache, vomiting, dizziness, visual disturbances appear during mannitol administration, the infusion should be stopped and the development of complications such as subdural and subarachnoid bleeding should be ruled out.

When using mannitol, it is necessary to monitor blood pressure, diuresis, and serum electrolyte concentrations (potassium, sodium).

Drug Interactions

With simultaneous use of mannitol with cardiac glycosides, an increase in their toxic effect associated with hypokalemia is possible.

Storage Conditions

Store at 8°C (46°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Mannitol [Biosintez, PJSC (Russia)]
Infusion solution 150 mg/1 ml: 200 ml or 400 ml fl.; 250 ml or 500 ml containers

Marketing Authorization Holder

Biosintez, PJSC (Russia)

Dosage Form

Mannitol

Infusion solution 150 mg/1 ml: 200 ml or 400 ml fl.; 250 ml or 500 ml containers

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 L
Mannitol	150 g

Excipients: sodium chloride – 9 g, water for injections – up to 1 L.

200 ml – glass bottles (1) – cardboard packs.
400 ml – glass bottles (1) – cardboard packs.
250 ml – polymer containers (1) – secondary film bags.
500 ml – polymer containers (1) – secondary film bags.

Mannitol [Grotex, LLC (Russia)]
Infusion solution 150 mg/ml: 100 ml, 200 ml, 250 ml, 400 ml, 500 ml or 1000 ml fl.

Marketing Authorization Holder

Grotex, LLC (Russia)

Dosage Form

Mannitol

Infusion solution 150 mg/ml: 100 ml, 200 ml, 250 ml, 400 ml, 500 ml or 1000 ml fl.

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 L
Mannitol	150 g

Excipients: sodium chloride – 9 g, water for injections – up to 1 L.

Theoretical osmolarity 1132 mOsm/L.

100 ml – polypropylene bottles (1) – cardboard packs.
200 ml – polypropylene bottles (1) – cardboard packs.
250 ml – polypropylene bottles (1) – cardboard packs.
400 ml – polypropylene bottles (1) – cardboard packs.
500 ml – polypropylene bottles (1) – cardboard packs.
1000 ml – polypropylene bottles (1) – cardboard packs.
100 ml – polypropylene bottles – cardboard boxes (for hospitals).
200 ml – polypropylene bottles – cardboard boxes (for hospitals).
250 ml – polypropylene bottles – cardboard boxes (for hospitals).
400 ml – polypropylene bottles – cardboard boxes (for hospitals).
500 ml – polypropylene bottles – cardboard boxes (for hospitals).
1000 ml – polypropylene bottles – cardboard boxes (for hospitals).

Mannitol [Dalkhimpharm, JSC (Russia)]
Infusion solution 150 mg/ml: 100 ml, 200 ml or 400 ml

Marketing Authorization Holder

Dalkhimpharm, JSC (Russia)

Dosage Form

Mannitol

Infusion solution 150 mg/ml: 100 ml, 200 ml or 400 ml

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 ml
Mannitol	150 mg

Excipients: sodium chloride – 9 mg, water for injections – up to 1 ml.

Theoretical osmolarity — 1131 mOsm/ml.

100 ml – glass bottles for blood (1) – cardboard packs (1).
200 ml – glass bottles for blood (1) – cardboard packs (1).
400 ml – glass bottles for blood (1) – cardboard packs (1).

Mannitol [Medsintez Plant, LLC (Russia)]
Infusion solution 150 mg/1 ml: 100 ml 50 or 75 pcs., 250 ml 24 or 36 pcs., 500 ml 12 or 18 pcs. or 1000 ml 6 or 9 pcs. containers

Marketing Authorization Holder

Medsintez Plant, LLC (Russia)

Dosage Form

Mannitol

Infusion solution 150 mg/1 ml: 100 ml 50 or 75 pcs., 250 ml 24 or 36 pcs., 500 ml 12 or 18 pcs. or 1000 ml 6 or 9 pcs. containers

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 L
Mannitol	150 g

Excipients: sodium chloride – 9 g, water for injections – up to 1 L.

Theoretical osmolarity 1132 mOsm/L.

100 ml – polymer containers (1) – bags (50) – cardboard boxes (for hospitals).
100 ml – polymer containers (1) – bags (75) – cardboard boxes (for hospitals).
250 ml – polymer containers (1) – bags (24) – cardboard boxes (for hospitals).
250 ml – polymer containers (1) – bags (36) – cardboard boxes (for hospitals).
500 ml – polymer containers (1) – bags (12) – cardboard boxes (for hospitals).
500 ml – polymer containers (1) – bags (18) – cardboard boxes (for hospitals).
1000 ml – polymer containers (1) – bags (6) – cardboard boxes (for hospitals).
1000 ml – polymer containers (1) – bags (9) – cardboard boxes (for hospitals).

Mannitol [IST-Pharm, LLC (Russia)]
Infusion solution 150 mg/ml: 250 ml or 500 ml bot. 1, 12, 15, 24, 28 pcs.

Marketing Authorization Holder

IST-Pharm, LLC (Russia)

Dosage Form

Mannitol

Infusion solution 150 mg/ml: 250 ml or 500 ml bot. 1, 12, 15, 24, 28 pcs.

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 ml
Mannitol	150 mg

Excipients: sodium chloride 9 mg, water for injections up to 1 ml.

Theoretical osmolarity: 1132 mOsm/L.

250 ml – polyethylene bottles (1) – cardboard packs.
250 ml – polyethylene bottles (1) – cardboard packs (12) – cardboard boxes.
250 ml – polyethylene bottles (1) – cardboard packs (15) – cardboard boxes.
250 ml – polyethylene bottles (1) – cardboard packs (24) – cardboard boxes.
250 ml – polyethylene bottles (1) – cardboard packs (28) – cardboard boxes.
250 ml – bottles (1) – polyethylene bags (24) – cardboard boxes.
500 ml – polyethylene bottles (1) – cardboard packs.
500 ml – polyethylene bottles (1) – cardboard packs (12) – cardboard boxes.
500 ml – polyethylene bottles (1) – cardboard packs (15) – cardboard boxes.
500 ml – polyethylene bottles (1) – cardboard packs (24) – cardboard boxes.
500 ml – polyethylene bottles (1) – cardboard packs (28) – cardboard boxes.
250 ml – polyethylene bottles (1) – polymer bags (for hospitals).
250 ml – polyethylene bottles (for hospitals).
250 ml – polyethylene bottles (12) – cardboard boxes (for hospitals).
250 ml – polyethylene bottles (15) – cardboard boxes (for hospitals).
250 ml – polyethylene bottles (24) – cardboard boxes (for hospitals).
250 ml – polyethylene bottles (28) – cardboard boxes (for hospitals).
500 ml – polyethylene bottles (1) – polymer bags (for hospitals).
500 ml – polyethylene bottles (for hospitals).
500 ml – polyethylene bottles (12) – cardboard boxes (for hospitals).
500 ml – polyethylene bottles (15) – cardboard boxes (for hospitals).
500 ml – polyethylene bottles (24) – cardboard boxes (for hospitals).
500 ml – polyethylene bottles (28) – cardboard boxes (for hospitals).
500 ml – bottles (1) – polyethylene bags (24) – cardboard boxes.

Mannitol [Kursk Biofactory - Firm "BIOK", FSUE (Russia)]
Infusion solution 150 mg/ml: 200 ml, 250, 400 ml or 450 ml bottles

Marketing Authorization Holder

Kursk Biofactory – Firm "BIOK", FSUE (Russia)

Dosage Form

Mannitol

Infusion solution 150 mg/ml: 200 ml, 250, 400 ml or 450 ml bottles

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 ml
Mannitol	150 mg

Excipients: sodium chloride – 0.9 g, water for injections – up to 100 ml.

Theoretical osmolarity – 1131 mOsm/ml.

200 ml – glass bottles (1) – cardboard packs.
400 ml – glass bottles (1) – cardboard packs.
250 ml – glass bottles (20) – cardboard boxes (for hospitals).
250 ml – glass bottles (24) – cardboard boxes (for hospitals).
250 ml – glass bottles (28) – cardboard boxes (for hospitals).
450 ml – glass bottles (15) – cardboard boxes (for hospitals).

Mannitol [Mosfarm LLC (Russia)]
Infusion solution 10%: 100 ml bot. 36 pcs., 200 ml 28 pcs. or 400 ml 15 pcs.
Infusion solution 15%: 100 ml bot. 36 pcs., 200 ml 28 pcs. or 400 ml 15 pcs.

Marketing Authorization Holder

Mosfarm LLC (Russia)

Dosage Forms

	Mannitol	Infusion solution 10%: 100 ml bot. 36 pcs., 200 ml 28 pcs. or 400 ml 15 pcs.
		Infusion solution 15%: 100 ml bot. 36 pcs., 200 ml 28 pcs. or 400 ml 15 pcs.

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 L
Mannitol	100 g

Excipients: sodium chloride – 9 g, water for injections – up to 1 L.

Theoretical osmolarity 857 mOsm/L.

100 ml – glass bottles (36) – cardboard boxes (for hospitals).
200 ml – glass bottles (28) – cardboard boxes (for hospitals).
400 ml – glass bottles (15) – cardboard boxes (for hospitals).
100 ml – containers (44) – cardboard boxes (for hospitals).
200 ml – containers (32) – cardboard boxes (for hospitals).
250 ml – containers (24) – cardboard boxes (for hospitals).
250 ml – containers (28) – cardboard boxes (for hospitals).
300 ml – containers (20) – cardboard boxes (for hospitals).
400 ml – containers (16) – cardboard boxes (for hospitals).
500 ml – containers (12) – cardboard boxes (for hospitals).
600 ml – containers (10) – cardboard boxes (for hospitals).
800 ml – containers (8) – cardboard boxes (for hospitals).
1000 ml – containers (6) – cardboard boxes (for hospitals).
2000 ml – containers (4) – cardboard boxes (for hospitals).
3000 ml – containers (2) – cardboard boxes (for hospitals).

Infusion solution transparent, colorless.

	1 L
Mannitol	150 g

Excipients: sodium chloride – 9 g, water for injections – up to 1 L.

Theoretical osmolarity 1132 mOsm/L.

Mannitol [KFK Medpolymer, LLC (Russia)]
Infusion solution 100 mg/ml: 100 ml, 200 ml, 250 ml, 400 ml, 500 ml or 1000 ml cont.

Marketing Authorization Holder

KFK Medpolymer, LLC (Russia)

Dosage Form

Mannitol

Infusion solution 100 mg/ml: 100 ml, 200 ml, 250 ml, 400 ml, 500 ml or 1000 ml cont.

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 ml
Mannitol	100 mg

Excipients: sodium chloride 9 mg, water for injections up to 1 ml.

100 ml – polyvinyl chloride containers (1) – polypropylene bags (44) – cardboard boxes.
200 ml – polyvinyl chloride containers (1) – polypropylene bags (28) – cardboard boxes.
250 ml – polyvinyl chloride containers (1) – polypropylene bags (24) – cardboard boxes.
400 ml – polyvinyl chloride containers (1) – polypropylene bags (16) – cardboard boxes.
500 ml – polyvinyl chloride containers (1) – polypropylene bags (12) – cardboard boxes.
1000 ml – polyvinyl chloride containers (1) – polypropylene bags (6) – cardboard boxes.
100 ml – polymeric containers (1) polyolefin – polypropylene bags (44) – cardboard boxes.
200 ml – polymeric containers (1) polyolefin – polypropylene bags (28) – cardboard boxes.
250 ml – polymeric containers (1) polyolefin – polypropylene bags (24) – cardboard boxes.
400 ml – polymeric containers (1) polyolefin – polypropylene bags (16) – cardboard boxes.
500 ml – polymeric containers (1) polyolefin – polypropylene bags (12) – cardboard boxes.
1000 ml – polymeric containers (1) polyolefin – polypropylene bags (6) – cardboard boxes.
100 ml – polymeric containers (44) polyolefin – cardboard boxes.
200 ml – polymeric containers (28) polyolefin – cardboard boxes.
250 ml – polymeric containers (24) polyolefin – cardboard boxes.
400 ml – polymeric containers (16) polyolefin – cardboard boxes.
500 ml – polymeric containers (12) polyolefin – cardboard boxes.
1000 ml – polymeric containers (6) polyolefin – cardboard boxes.
100 ml – polymeric containers (1) with 1-port – bags (1) – cardboard boxes.
100 ml – polymeric containers (1) with 1-port – cardboard boxes.
100 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
100 ml – polymeric containers (1) with 2-ports – cardboard boxes.
200 ml – polymeric containers (1) with 1-port – bags (1) – cardboard boxes.
200 ml – polymeric containers (1) with 1-port – cardboard boxes.
200 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
200 ml – polymeric containers (1) with 2-ports – cardboard boxes.
250 ml – polymeric containers (1) with 1-port – bags (1) – cardboard boxes.
250 ml – polymeric containers (1) with 1-port – cardboard boxes.
250 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
250 ml – polymeric containers (1) with 2-ports – cardboard boxes.
400 ml – polymeric containers (1) with 1-port – bags (1) – cardboard boxes.
400 ml – polymeric containers (1) with 1-port – cardboard boxes.
400 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
400 ml – polymeric containers (1) with 2-ports – cardboard boxes.
500 ml – polymeric containers (1) with 1-port – bags (1) – cardboard boxes.
500 ml – containers (1) with 1-port – cardboard boxes.
500 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
1000 ml – polymeric containers (1) with 1-port – bags (1) – cardboard boxes.
1000 ml – containers (1) with 1-port – cardboard boxes.
1000 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
100 ml – polymeric containers (1) with 1-port – bags (1) – boxes.
100 ml – containers (1) with 1-port – boxes.
100 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
100 ml – containers (1) with 2-ports – cardboard boxes.
200 ml – polymeric containers (1) with 1-port – bags (1) – boxes.
200 ml – containers (1) with 1-port – boxes.
200 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
200 ml – containers (1) with 2-ports – cardboard boxes.
250 ml – polymeric containers (1) with 1-port – bags (1) – boxes.
250 ml – containers (1) with 1-port – boxes.
250 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
250 ml – containers (1) with 2-ports – cardboard boxes.
400 ml – polymeric containers (1) with 1-port – bags (1) – boxes.
400 ml – containers (1) with 1-port – boxes.
400 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
400 ml – containers (1) with 2-ports – cardboard boxes.
500 ml – polymeric containers (1) with 1-port – bags (1) – boxes.
500 ml – containers (1) with 1-port – boxes.
500 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
500 ml – containers (1) with 2-ports – cardboard boxes.
1000 ml – polymeric containers (1) with 1-port – bags (1) – boxes.
1000 ml – containers (1) with 1-port – boxes.
1000 ml – polymeric containers (1) with 2-ports – bags (1) – cardboard boxes.
1000 ml – containers (1) with 2-ports – cardboard boxes.

Mannitol [KFK Medpolymer, LLC (Russia)]
Infusion solution 150 mg/ml: 100 ml, 200 ml, 250 ml, 400 ml, 500 ml or 1000 ml cont.

Marketing Authorization Holder

KFK Medpolymer, LLC (Russia)

Dosage Form

Mannitol

Infusion solution 150 mg/ml: 100 ml, 200 ml, 250 ml, 400 ml, 500 ml or 1000 ml cont.

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 ml
Mannitol	150 mg

Excipients: sodium chloride 9 mg, water for injections up to 1 ml.

Mannitol-Kelun-Kazpharm [Kelun-Kazpharm, LLP (Kazakhstan)]
Infusion solution 15%: 200 ml or 400 ml fl.

Marketing Authorization Holder

Kelun-Kazpharm, LLP (Kazakhstan)

Dosage Form

Mannitol-Kelun-Kazpharm

Infusion solution 15%: 200 ml or 400 ml fl.

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 ml
Mannitol	150 mg

Excipients: sodium chloride – 9 mg, water for injections – up to 1 ml.

Theoretical osmolarity 1131.3 mOsm/L.

200 ml – polypropylene bottles (1) – cardboard packs.
400 ml – polypropylene bottles (1) – cardboard packs.
200 ml – polypropylene bottles (30) – cardboard boxes (for hospitals).
200 ml – polypropylene bottles (40) – cardboard boxes (for hospitals).
400 ml – polypropylene bottles (30) – cardboard boxes (for hospitals).
400 ml – polypropylene bottles (40) – cardboard boxes (for hospitals).

Mannitol-SF [Sphere-Pharm, LLC (Russia)]
Infusion solution 150 mg/ml: 250 ml bottles 16 or 32 pcs., 500 ml bottles 16 or 18 pcs., 250 ml or 500 ml containers

Marketing Authorization Holder

Sphere-Pharm, LLC (Russia)

Dosage Form

Mannitol-SF

Infusion solution 150 mg/ml: 250 ml bottles 16 or 32 pcs., 500 ml bottles 16 or 18 pcs., 250 ml or 500 ml containers

Dosage Form, Packaging, and Composition

Infusion solution transparent, colorless.

	1 L
Mannitol	150 g

Excipients: sodium chloride – 9 g, water for injections – up to 1 L.

Theoretical osmolarity 1132 mOsm/L.

250 ml – bottles (16) – cardboard boxes (for hospitals).
250 ml – bottles (32) – cardboard boxes (for hospitals).
250 ml – containers (1) – bags.
500 ml – bottles (16) – cardboard boxes (for hospitals).
500 ml – bottles (18) – cardboard boxes (for hospitals).
500 ml – containers (1) – bags.

Medixlife (Author)

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