Mebicar^® (Tablets) Instructions for Use

ATC Code

N06BX21 (Temgicoluril)

Active Substance

Temgicoluril (Rec.INN registered by WHO)

Clinical-Pharmacological Group

Anxiolytic (tranquilizer)

Pharmacotherapeutic Group

Psychoanaleptics; psychostimulants, agents used in attention deficit hyperactivity disorder, and nootropic agents; other psychostimulants and nootropic agents

Pharmacological Action

Anxiolytic agent, tetramethyltetraazabicyclooctanedione. It also has an anticonvulsant effect. Without having a direct hypnotic effect, it regulates disturbed night sleep. It does not exhibit central or peripheral cholinoblocking properties. The anxiolytic effect is not accompanied by muscle relaxation and impaired coordination of movements.

Pharmacokinetics

It is excreted by the kidneys within 24 hours after administration.

Indications

Neuroses and neurosis-like states (irritability, emotional lability, anxiety, fear). Anxious-paranoid syndrome in schizophrenia, involutional and vascular psychoses. Chronic verbal hallucinosis of organic genesis. Complex therapy for the treatment of patients with cardialgia, coronary artery disease and rehabilitation after myocardial infarction. Reduction of craving for tobacco smoking, ethanol, psychoactive substances; improvement of tolerance to neuroleptics and tranquilizers.

ICD codes

Dosage Regimen

Administer Mebicar^® orally, regardless of food intake.

For adults, the typical dosage is 300 mg to 900 mg taken two to three times daily.

Do not exceed a maximum single dose of 3 grams.

Do not exceed a maximum daily dose of 10 grams.

For the management of neuroses, anxiety, and adjunct therapy in cardiac conditions, treatment duration typically ranges from several days to two to three months.

For chronic mental illnesses, such as schizophrenia, treatment courses may extend up to six months.

Adhere strictly to the dosage and duration prescribed by the physician.

Individualize the dosage based on the specific indication and patient response.

Adverse Reactions

Possible allergic reactions (skin itching), decreased blood pressure, hypothermia (by 1-1.5°C (29.3°F)), dyspepsia.

Contraindications

Hypersensitivity to temgicoluril.

Special Precautions

Decreased blood pressure and body temperature are not a reason to discontinue therapy and normalize on their own.

Influence on the ability to drive vehicles and mechanisms

During the treatment period, caution must be exercised when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug Interactions

It enhances the effect of hypnotic agents.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.