Novocaine (Solution, Suppositories) Instructions for Use

Instructions
Dosage forms

ATC Code

N01BA02 (Procaine)

Active Substance

Procaine (Rec.INN registered by WHO)

Clinical-Pharmacological Group

Local anesthetic

Pharmacotherapeutic Group

Anesthetics; local anesthetics; aminobenzoic acid esters

Pharmacological Action

A local anesthetic with moderate anesthetic activity and a wide therapeutic range. Being a weak base, it blocks sodium channels, prevents the generation of impulses in the endings of sensory nerves and the conduction of impulses along nerve fibers.

It alters the action potential in nerve cell membranes without a pronounced effect on the resting potential. It suppresses the conduction of not only pain impulses but also impulses of other modalities.

Upon absorption and direct vascular introduction into the bloodstream, it reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from preganglionic endings (has some ganglion-blocking action), relieves smooth muscle spasm, reduces myocardial excitability and the excitability of the motor areas of the cerebral cortex.

It eliminates the descending inhibitory influences of the brainstem reticular formation. It depresses polysynaptic reflexes. It has short anesthetic activity (the duration of infiltration anesthesia is 0.5-1 hour).

Pharmacokinetics

It undergoes complete systemic absorption. The degree of absorption depends on the site and route of administration (especially on vascularization and blood flow rate at the injection site) and the final dose (amount and concentration).

Procaine is rapidly hydrolyzed by plasma and liver esterases to form two main pharmacologically active metabolites: diethylaminoethanol (which has a moderate vasodilatory effect) and p-aminobenzoic acid (which is a competitive antagonist of sulfonamide drugs and may weaken their antimicrobial action).

T_1/2 is 30-50 seconds, in the neonatal period it is 54-114 seconds. It is excreted mainly by the kidneys in the form of metabolites; no more than 2% is excreted unchanged.

Indications

Infiltration (including intraosseous), conduction, retrobulbar (regional), epidural anesthesia; vagosympathetic cervical, paranephric, circular and paravertebral blockades.

ICD codes

Open the list of ICD codes

ICD-10 code	Indication
Z51.4	Preparatory procedures for subsequent treatment or examination, not elsewhere classified

ICD-11 code	Indication
QB9A	Preparatory procedures for subsequent treatment

Dosage Regimen

The method of application and dosage regimen for a specific drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly adhere to the compliance of the dosage form of a specific drug with the indications for use and dosage regimen.

Solution

Only for procaine solution 5 mg/ml (0.5%).

For infiltration anesthesia, 350-600 mg (70-120 ml) is administered. Maximum doses for infiltration anesthesia for adults: first single dose at the beginning of surgery – not more than 0.75 g (150 ml), then during each hour of surgery – not more than 2 g (400 ml) of solution.

For paranephric blockade (according to A.V. Vishnevsky), 50-80 ml is injected into the perirenal tissue.

For circular and paravertebral blockade, 5-10 ml is injected intradermally. For vagosympathetic blockade, 30-40 ml is administered.

To reduce absorption and prolong the action during local anesthesia, a 0.1% solution of epinephrine hydrochloride is additionally administered – 1 drop per 2-5-10 ml of procaine solution.

The maximum dose for use in children over 12 years of age is 15 mg/kg.

Suppositories

Used rectally. The dosage regimen is set individually, depending on the clinical situation and the patient’s age. The duration of treatment is no more than 5 days.

Adverse Reactions

From the nervous system headache, dizziness, drowsiness, persistent anesthesia, weakness, motor restlessness, nervousness, loss of consciousness, convulsions, trismus, tremor, visual and auditory disturbances, nystagmus, cauda equina syndrome (paralysis of the legs, paresthesia), paralysis of the respiratory muscles, motor and sensory block.

From the cardiovascular system increase or decrease in blood pressure, collapse, peripheral vasodilation, bradycardia, arrhythmia, chest pain, changes in the process of excitation propagation in the heart, which are manifested on the ECG as a flat T wave or shortening of the ST segment.

From the respiratory system respiratory tract spasms or difficulty breathing.

From the digestive system nausea, vomiting.

Allergic reactions skin itching, skin rash, angioedema, anaphylactic reactions (including anaphylactic shock), urticaria.

Other involuntary urination, methemoglobinemia, hypothermia, shivering, swelling of the lips, face, mouth, tongue and throat.

Contraindications

Hypersensitivity to procaine; children under 12 years of age; pronounced fibrotic changes in tissues (for anesthesia by the creeping infiltrate method).

With caution emergency operations accompanied by acute blood loss; conditions accompanied by reduced hepatic blood flow (e.g., in chronic heart failure, liver diseases); progression of cardiovascular failure (usually due to the development of heart block and shock); inflammatory diseases or infection at the injection site; pseudocholinesterase deficiency; renal failure; children (from 12 to 18 years); elderly patients (over 65 years); debilitated patients.

Use in Pregnancy and Lactation

During pregnancy and breastfeeding, it should be used only after consultation with a doctor, in cases where the intended benefit to the mother outweighs the potential risk to the fetus or infant.

Use in Hepatic Impairment

Should be used with caution in patients with conditions accompanied by reduced hepatic blood flow (e.g., with liver diseases).

Use in Renal Impairment

Should be used with caution in patients with renal failure.

Pediatric Use

Contraindicated for use in children under 12 years of age. Should be used with caution in children and adolescents aged 12-18 years.

Geriatric Use

Should be used with caution in elderly patients (over 65 years).

Special Precautions

Anesthesia should be performed by experienced specialists in an appropriately equipped room with readily available equipment and drugs necessary for cardiomonitoring and resuscitation measures.

To prevent accidental intravascular injection, it is recommended to perform an aspiration test (in 2 stages).

When using the product, monitoring of the function of the cardiovascular and respiratory systems, and the CNS is required.

The use of MAO inhibitors is contraindicated for at least 10 days before using procaine.

Before using procaine, it is necessary to conduct tests for individual sensitivity.

It should be taken into account that during local anesthesia when using the same total dose, the toxicity of procaine is higher the more concentrated the solution used.

It is not absorbed from mucous membranes; does not provide superficial anesthesia when applied to the skin.

Influence on the ability to drive vehicles and machinery

During the use of procaine, patients should exercise caution when driving vehicles and machinery, as well as when engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug Interactions

When used concomitantly, Procaine enhances the depressant effect on the CNS of general anesthetics, hypnotics and sedatives, narcotic analgesics and tranquilizers.

With simultaneous use, anticoagulants (ardeparin sodium, dalteparin sodium, danaparoid sodium, enoxaparin sodium, heparin sodium, warfarin) increase the risk of bleeding.

When treating the injection site of a local anesthetic with disinfectant solutions containing heavy metals, the risk of developing a local reaction in the form of soreness and swelling increases.

With simultaneous use of procaine with MAO inhibitors (furazolidone, procarbazine, selegiline), the risk of hypotension increases.

When used concomitantly, Procaine enhances and prolongs the action of muscle relaxants.

When procaine is used together with narcotic analgesics, an additive effect is noted, which is used during spinal and epidural anesthesia, while respiratory depression is enhanced.

With simultaneous use, vasoconstrictors (epinephrine, methoxamine, phenylephrine) prolong the local anesthetic action of procaine.

With simultaneous use, Procaine reduces the antimyasthenic effect of drugs, especially when used in high doses, which requires additional correction of myasthenia treatment.

With simultaneous use, cholinesterase inhibitors (antimyasthenic drugs, cyclophosphamide, demecarium bromide, ecothiopate iodide, thiotepa) reduce the metabolism of procaine.

The metabolite of procaine (p-aminobenzoic acid) is an antagonist of sulfonamides.

When using local anesthetics for epidural anesthesia with guanadrel, guanethidine, mecamylamine, trimethaphan camsilate, the risk of a sharp decrease in blood pressure and bradycardia increases.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.

Medical Disclaimer

Brand (or Active Substance), Marketing Authorisation Holder, Dosage Form

Novocaine [Mapichem AG (Switzerland)]
Solution for injection 25 mg/5 ml: amp. 10 pcs.

Marketing Authorization Holder

Mapichem AG (Switzerland)

Manufactured By

Wuhu Kangqi Pharmaceutical Co. Ltd. (China)

Dosage Form

Novocaine

Solution for injection 25 mg/5 ml: amp. 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection	1 ml	1 amp.
Procaine	5 mg	25 mg

5 ml – dark glass ampoules (10) – plastic contour packs (1) – cardboard packs.

Novocaine [Armavir Biopharmaceutical Plant, FSE (Russia)]
Solution for injection 0.5%: amp. 2 ml, 5 ml or 10 ml 10 pcs.

Marketing Authorization Holder

Armavir Biopharmaceutical Plant, FSE (Russia)

Dosage Form

Novocaine

Solution for injection 0.5%: amp. 2 ml, 5 ml or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml
Procaine	5 mg

2 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (10) – cardboard packs.
10 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (5) – contour cell packs (2) – cardboard packs.

Novocaine [Armavir Biopharmaceutical Plant, FSE (Russia)]
Solution for injection 2%: amp. 2 ml, 5 ml or 10 ml 10 pcs.

Marketing Authorization Holder

Armavir Biopharmaceutical Plant, FSE (Russia)

Dosage Form

Novocaine

Solution for injection 2%: amp. 2 ml, 5 ml or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 2%	1 ml
Procaine	20 mg

2 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (10) – cardboard packs.
10 ml – ampoules (10) – cardboard packs.
2 ml – ampoules (5) – contour cell packs (2) – cardboard packs.
5 ml – ampoules (5) – contour cell packs (2) – cardboard packs.

Novocaine [Atoll LLC (Russia)]
Solution for injection 0.5%: amp. 5 ml 10 pcs.

Marketing Authorization Holder

Atoll LLC (Russia)

Manufactured By

Ozon, LLC (Russia)

Dosage Form

Novocaine

Solution for injection 0.5%: amp. 5 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5% transparent, colorless.

	1 ml
Procaine	5 mg

Excipients: hydrochloric acid solution 0.1M – to pH 3.8-4.5, water for injection – to 1 l.

5 ml – ampoules (10) – cardboard boxes.

Novocaine [Biosintez, PJSC (Russia)]
Rectal suppositories 100 mg: 10 pcs.

Marketing Authorization Holder

Biosintez, PJSC (Russia)

Dosage Form

Novocaine

Rectal suppositories 100 mg: 10 pcs.

Dosage Form, Packaging, and Composition

Rectal suppositories	1 supp.
Procaine	100 mg

5 pcs. – contour cell packs (2) – cardboard packs.

Novocaine [Biosintez, PJSC (Russia)]
Solution for injection 0.25%: 200 ml bottle 1, 24 or 28 pcs., 400 ml bottle 1, 12 or 15 pcs.

Marketing Authorization Holder

Biosintez, PJSC (Russia)

Dosage Form

Novocaine

Solution for injection 0.25%: 200 ml bottle 1, 24 or 28 pcs., 400 ml bottle 1, 12 or 15 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.25% transparent, colorless.

	1 ml
Procaine	2.5 mg

Excipients: hydrochloric acid solution 0.1M – to pH 3.8-4.5, water for injection – to 1 ml.

200 ml – bottles (1) – cardboard packs.
200 ml – bottles (24) – cardboard boxes.
200 ml – bottles (28) – cardboard boxes.
400 ml – bottles (1) – cardboard packs.
400 ml – bottles (12) – cardboard boxes.
400 ml – bottles (15) – cardboard boxes.

Novocaine [Biosintez, PJSC (Russia)]
Solution for injection 0.5%: 200 ml bottle 1, 24 or 28 pcs., 400 ml bottle 1, 12 or 15 pcs.

Marketing Authorization Holder

Biosintez, PJSC (Russia)

Dosage Form

Novocaine

Solution for injection 0.5%: 200 ml bottle 1, 24 or 28 pcs., 400 ml bottle 1, 12 or 15 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5% colorless, transparent.

	1 ml
Procaine	5 mg

Excipients: hydrochloric acid solution 0.1M – to pH 3.8-4.5, water for injection – to 1 ml.

Novocaine [Biosintez, PJSC (Russia)]
Solution for injection 0.25%: amp. 1 ml, 2 ml, 5 ml, or 10 ml 10 pcs.

Marketing Authorization Holder

Biosintez, PJSC (Russia)

Dosage Form

Novocaine

Solution for injection 0.25%: amp. 1 ml, 2 ml, 5 ml, or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.25%	1 ml
Procaine	2.5 mg

1 ml – ampoules (10) – cardboard packs
10 ml – ampoules (10) – cardboard packs
2 ml – ampoules (10) – cardboard packs
5 ml – ampoules (10) – cardboard packs.

Novocaine [Biosintez, PJSC (Russia)]
Solution for injection 0.5%: amp. 1 ml, 2 ml, 5 ml, or 10 ml 10 pcs.

Marketing Authorization Holder

Biosintez, PJSC (Russia)

Dosage Form

Novocaine

Solution for injection 0.5%: amp. 1 ml, 2 ml, 5 ml, or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml
Procaine	5 mg

1 ml – ampoules (10) – carton packs.
2 ml – ampoules (10) – carton packs.
10 ml – ampoules (10) – carton packs.
5 ml – ampoules (10) – carton packs.
5 ml – ampoules (5) – contour cell packs (2) – carton packs.

Novocaine [Biosintez, PJSC (Russia)]
Solution for injection 1%: amp. 1 ml, 2 ml, 5 ml, or 10 ml 10 pcs.

Marketing Authorization Holder

Biosintez, PJSC (Russia)

Dosage Form

Novocaine

Solution for injection 1%: amp. 1 ml, 2 ml, 5 ml, or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 1%	1 ml
Procaine	10 mg

1 ml – ampoules (10) – carton packs
10 ml – ampoules (10) – carton packs
2 ml – ampoules (10) – carton packs
5 ml – ampoules (10) – carton packs.

Novocaine [Biosintez, PJSC (Russia)]
Solution for injection 2%: amp. 1 ml, 2 ml, 5 ml, or 10 ml 10 pcs.

Marketing Authorization Holder

Biosintez, PJSC (Russia)

Dosage Form

Novocaine

Solution for injection 2%: amp. 1 ml, 2 ml, 5 ml, or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 2%	1 ml
Procaine	20 mg

1 ml – ampoules (10) – carton packs
10 ml – ampoules (10) – carton packs
2 ml – ampoules (10) – carton packs
5 ml – ampoules (10) – carton packs.

Novocaine [Biokhimik, JSC (Russia)]
Injection solution 0.5% (1 g/200 ml): vial 1, 25 or 28 pcs

Marketing Authorization Holder

Biokhimik, JSC (Russia)

Dosage Form

Novocaine

Injection solution 0.5% (1 g/200 ml): vial 1, 25 or 28 pcs

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml	1 vial
Procaine	5 mg	1 g

200 ml – vials for blood substitutes (1) – carton packs.
200 ml – vials for blood substitutes (24) – carton boxes.
200 ml – vials for blood substitutes (28) – carton packs.

Novocaine [Biokhimik, JSC (Russia)]
Injection solution 0.5% (2 g/400 ml): vial 1, 15 or 25 pcs

Marketing Authorization Holder

Biokhimik, JSC (Russia)

Dosage Form

Novocaine

Injection solution 0.5% (2 g/400 ml): vial 1, 15 or 25 pcs

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml	1 vial
Procaine	5 mg	2 g

400 ml – vials for blood substitutes (1) – carton packs.
400 ml – vials for blood substitutes (12) – carton boxes.
400 ml – vials for blood substitutes (15) – carton boxes.

Novocaine [Velpharm, LLC (Russia)]
Solution for injection 5 mg/1 ml: amp. 2 ml, 5 ml or 10 ml 5 or 10 pcs.
Solution for injection 20 mg/1 ml: amp. 2 ml, 5 ml or 10 ml 5 or 10 pcs.

Marketing Authorization Holder

Velpharm, LLC (Russia)

Dosage Forms

	Novocaine	Solution for injection 5 mg/1 ml: amp. 2 ml, 5 ml or 10 ml 5 or 10 pcs.
		Solution for injection 20 mg/1 ml: amp. 2 ml, 5 ml or 10 ml 5 or 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection as a clear, colorless or slightly colored liquid.

	1 ml
Procaine hydrochloride	5 mg

Excipients: 0.1M hydrochloric acid solution, water for injections.

2 ml – ampoules (5) – contour cell packs (1) – carton packs.
2 ml – ampoules (5) – contour cell packs (2) – carton packs.
5 ml – ampoules (5) – contour cell packs (1) – carton packs.
5 ml – ampoules (5) – contour cell packs (2) – carton packs.
10 ml – ampoules (5) – contour cell packs (1) – carton packs.
10 ml – ampoules (5) – contour cell packs (2) – carton packs.

Solution for injection as a clear, colorless or slightly colored liquid.

	1 ml
Procaine hydrochloride	20 mg

Excipients: 0.1M hydrochloric acid solution, water for injections.

Novocaine [Grotex, LLC (Russia)]
Solution for injection 0.5%: amp. 5 ml or 10 ml 5 or 10 pcs. or vial 100 ml, 200 ml, 250 ml, 400 ml or 500 ml 1 pc.

Marketing Authorization Holder

Grotex, LLC (Russia)

Dosage Form

Novocaine

Solution for injection 0.5%: amp. 5 ml or 10 ml 5 or 10 pcs. or vial 100 ml, 200 ml, 250 ml, 400 ml or 500 ml 1 pc.

Dosage Form, Packaging, and Composition

Solution for injection 0.5% clear, colorless or slightly colored.

	1 ml
Procaine hydrochloride	5 mg

Excipients: 0.1M hydrochloric acid solution – to pH 3.8-4.5, water for injections – to 1 ml.

5 ml – polyethylene ampoules (5) – carton packs.
5 ml – polyethylene ampoules (10) – carton packs.
10 ml – polyethylene ampoules (5) – carton packs.
10 ml – polyethylene ampoules (10) – carton packs.
100 ml – polypropylene vials (1) – carton packs.
200 ml – polypropylene vials (1) – carton packs.
250 ml – polypropylene vials (1) – carton packs.
400 ml – polypropylene vials (1) – carton packs.
500 ml – polypropylene vials (1) – carton packs.

Novocaine [Grotex, LLC (Russia)]
Solution for injection 0.25%: bottle 100 ml, 200 ml, 250 ml, 400 ml, or 500 ml 1 pc.

Marketing Authorization Holder

Grotex, LLC (Russia)

Dosage Form

Novocaine

Solution for injection 0.25%: bottle 100 ml, 200 ml, 250 ml, 400 ml, or 500 ml 1 pc.

Dosage Form, Packaging, and Composition

Solution for injection 0.25% clear, colorless or slightly colored.

	1 ml
Procaine hydrochloride	2.5 mg

Infusion solution 0.5%	1 ml	1 vial
Procaine	5 mg	2 g

Novocaine [Deko Company, LLC (Russia)]
Solution for injection 5 mg/ml: 5 ml amp. 10 pcs.

Marketing Authorization Holder

Deko Company, LLC (Russia)

Dosage Form

Novocaine

Solution for injection 5 mg/ml: 5 ml amp. 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection	1 ml
Procaine	5 mg

5 ml – ampoules (5) – contour cell packs (2) – cardboard packs.
5 ml – ampoules (10) – contour cell packs (1) – cardboard packs.

Novocaine [Mosfarm LLC (Russia)]
Solution for injection 0.5%: bottles 100 ml, 200 ml or 400 ml
Solution for injection 0.25%: bottles 100 ml, 200 ml or 400 ml

Marketing Authorization Holder

Mosfarm LLC (Russia)

Dosage Forms

	Novocaine	Solution for injection 0.5%: bottles 100 ml, 200 ml or 400 ml
		Solution for injection 0.25%: bottles 100 ml, 200 ml or 400 ml

Dosage Form, Packaging, and Composition

Solution for injection 0.5% transparent, colorless.

	1 L
Procaine hydrochloride	5 g

Excipients: hydrochloric acid 0.1M solution – to pH 3.8-4.5, water for injection – to 1 L.

100 ml – Glass bottles with a capacity of 100 ml (1) – cardboard packs.
200 ml – glass bottles with a capacity of 250 ml (1) – cardboard packs.
400 ml – glass bottles with a capacity of 450 ml (1) – cardboard packs.
100 ml – Glass bottles with a capacity of 100 ml (36) – cardboard boxes (for hospitals).
200 ml – glass bottles with a capacity of 250 ml (15) – cardboard boxes (for hospitals).
200 ml – glass bottles with a capacity of 250 ml (28) – cardboard boxes (for hospitals).
400 ml – glass bottles with a capacity of 450 ml (15) – cardboard boxes (for hospitals).

Solution for injection 0.25% transparent, colorless.

	1 L
Procaine hydrochloride	2.5 g

Excipients: hydrochloric acid 0.1M solution – to pH 3.8-4.5, water for injection – to 1 L.

Novocaine [N.A. Semashko Moscow Chemical Pharmaceutical Preparations, JSC (Russia)]
Solution for injection 5 mg/1 ml: 5 ml or 10 ml amp. 10 pcs.

Marketing Authorization Holder

N.A. Semashko Moscow Chemical Pharmaceutical Preparations, JSC (Russia)

Dosage Form

Novocaine

Solution for injection 5 mg/1 ml: 5 ml or 10 ml amp. 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection	1 ml
Procaine	5 mg

10 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (10) – cardboard packs.

Novocaine [Nesvizh Medical Products Plant OJSC (Republic Of Belarus)]
Injection solution 0.5%: vial 200 ml or 400 ml
Injection solution 0.25%: vial 200 ml or 400 ml

Marketing Authorization Holder

Nesvizh Medical Products Plant OJSC (Republic Of Belarus)

Dosage Forms

	Novocaine	Injection solution 0.5%: vial 200 ml or 400 ml
		Injection solution 0.25%: vial 200 ml or 400 ml

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml
Procaine	5 mg

200 ml – vials for blood substitutes (1) – cardboard packs
400 ml – vials for blood substitutes (1) – cardboard packs.

Solution for injection 0.25%	1 ml
Procaine	2.5 mg

200 ml – vials for blood substitutes (1) – cardboard packs
400 ml – vials for blood substitutes (1) – cardboard packs.

Novocaine [Novosibkhimpharm, JSC (Russia)]
Solution for injection 0.5% (25 mg/5 ml): amp. 10 pcs.

Marketing Authorization Holder

Novosibkhimpharm, JSC (Russia)

Dosage Form

Novocaine

Solution for injection 0.5% (25 mg/5 ml): amp. 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml	1 amp.
Procaine	5 mg	25 mg

5 ml – ampoules (10) – cardboard packs.

Novocaine [Novosibkhimpharm, JSC (Russia)]
Solution for injection 0.5% (50 mg/10 ml): amp. 10 pcs.

Marketing Authorization Holder

Novosibkhimpharm, JSC (Russia)

Dosage Form

Novocaine

Solution for injection 0.5% (50 mg/10 ml): amp. 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml	1 amp.
Procaine	5 mg	50 mg

10 ml – ampoules (10) – cardboard packs.

Novocaine [Microgen NPO, JSC (Russia)]
Injection solution 5 mg/ml: 2 or 5 ml amp. 5, 10 or 20 pcs.

Marketing Authorization Holder

Microgen NPO, JSC (Russia)

Dosage Form

Novocaine

Injection solution 5 mg/ml: 2 or 5 ml amp. 5, 10 or 20 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml
Procaine	5 mg

2 ml – ampoules (10) of neutral glass – cardboard packs.
2 ml – ampoules (10) of neutral glass – cardboard boxes.
2 ml – ampoules (5) of neutral glass – contour cell packs (1) – cardboard packs.
2 ml – ampoules (5) of neutral glass – contour cell packs (2) – cardboard packs.
2 ml – ampoules (10) of neutral glass – contour cell packs (1) – cardboard packs.
2 ml – ampoules (10) of neutral glass – contour cell packs (2) – cardboard packs.
5 ml – ampoules (10) of neutral glass – cardboard packs.
5 ml – ampoules (10) of neutral glass – cardboard boxes.
5 ml – ampoules (5) of neutral glass – contour cell packs (1) – cardboard packs.
5 ml – ampoules (5) of neutral glass – contour cell packs (2) – cardboard packs.
5 ml – ampoules (10) of neutral glass – contour cell packs (1) – cardboard packs.
5 ml – ampoules (10) of neutral glass – contour cell packs (2) – cardboard packs.
2 ml – ampoules (10) of neutral glass complete with an ampoule knife or scarifier (if necessary) – cardboard boxes.
5 ml – ampoules (10) of neutral glass complete with an ampoule knife or scarifier (if necessary) – cardboard boxes.

Novocaine [Microgen NPO, JSC (Russia)]
Injection solution 5 mg/ml: 2 or 5 ml amp. 5, 10 or 20 pcs.

Marketing Authorization Holder

Microgen NPO, JSC (Russia)

Manufactured By

Virion NPO (Russia)

Dosage Form

Novocaine

Injection solution 5 mg/ml: 2 or 5 ml amp. 5, 10 or 20 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml
Procaine	5 mg

Novocaine [Organika, JSC (Russia)]
Solution for injection 0.5 %: amp. 5 ml or 10 ml 10 pcs.

Marketing Authorization Holder

Organika, JSC (Russia)

Dosage Form

Novocaine

Solution for injection 0.5 %: amp. 5 ml or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection	1 ml
Procaine	5 mg

5 ml – ampoules (10) – cardboard packs.
10 ml – ampoules (10) – cardboard packs.

Novocaine [Promomed Rus LLC (Russia)]
Solution for injection 0.25%: amp. 2 ml or 5 ml 10 pcs.

Marketing Authorization Holder

Promomed Rus LLC (Russia)

Dosage Form

Novocaine

Solution for injection 0.25%: amp. 2 ml or 5 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.25%	1 ml
Procaine	2.5 mg

2 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (10) – cardboard packs.

Novocaine [Promomed Rus LLC (Russia)]
Solution for injection 0.5%: amp. 2 ml or 5 ml 10 pcs.

Marketing Authorization Holder

Promomed Rus LLC (Russia)

Dosage Form

Novocaine

Solution for injection 0.5%: amp. 2 ml or 5 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 0.5%	1 ml
Procaine	5 mg

2 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (5) – contour cell packs (2) – cardboard packs.

Novocaine [Promomed Rus LLC (Russia)]
Solution for injection 1%: amp. 2 ml or 5 ml 10 pcs.

Marketing Authorization Holder

Promomed Rus LLC (Russia)

Dosage Form

Novocaine

Solution for injection 1%: amp. 2 ml or 5 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 1%	1 ml
Procaine	10 mg

2 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (10) – cardboard packs.

Novocaine [Promomed Rus LLC (Russia)]
Solution for injection 2%: amp. 2 ml or 5 ml 10 pcs.

Marketing Authorization Holder

Promomed Rus LLC (Russia)

Dosage Form

Novocaine

Solution for injection 2%: amp. 2 ml or 5 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection 2%	1 ml
Procaine	20 mg

2 ml – ampoules (10) – cardboard packs.
5 ml – ampoules (10) – cardboard packs.

Novocaine [Promomed Rus LLC (Russia)]
Injection solution 0.25% (500 mg/200 ml): vial 1, 25 or 28 pcs

Marketing Authorization Holder

Promomed Rus LLC (Russia)

Manufactured By

Biokhimik, JSC (Russia)

Dosage Form

Novocaine

Injection solution 0.25% (500 mg/200 ml): vial 1, 25 or 28 pcs

Dosage Form, Packaging, and Composition

Solution for injection 0.25%	1 ml
Procaine hydrochloride	2.5 mg

200 ml – vials for blood substitutes (1) – cardboard packs.
200 ml – vials for blood substitutes (24) – cardboard boxes.
200 ml – vials for blood substitutes (28) – cardboard boxes.

Novocaine [Sintez PJSC (Russia)]
Solution for injection 5 mg/1 ml: amp. 2 ml or 5 ml 5 or 10 pcs.

Marketing Authorization Holder

Sintez PJSC (Russia)

Dosage Form

Novocaine

Solution for injection 5 mg/1 ml: amp. 2 ml or 5 ml 5 or 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection in the form of a transparent, colorless liquid.

	1 ml
Procaine hydrochloride	5 mg

Excipients: hydrochloric acid solution 0.1M, water for injection.

2 ml – ampoules (5) – contour cell packs (1) – cardboard packs.
2 ml – ampoules (5) – contour cell packs (2) – cardboard packs.
5 ml – ampoules (5) – contour cell packs (1) – cardboard packs.
5 ml – ampoules (5) – contour cell packs (2) – cardboard packs.

Novocaine [Slavic Pharmacy, LLC (Russia)]
Solution for injection 5 mg/ml: 5 or 10 ml amp. 5 or 10 pcs.

Marketing Authorization Holder

Slavic Pharmacy, LLC (Russia)

Dosage Form

Novocaine

Solution for injection 5 mg/ml: 5 or 10 ml amp. 5 or 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection transparent, colorless.

	1 ml
Procaine	5 mg

5 ml – polymer ampoules (5) – cardboard packs.
5 ml – polymer ampoules (10) – cardboard packs.
10 ml – polymer ampoules (5) – cardboard packs.
10 ml – polymer ampoules (10) – cardboard packs.

Novocaine [Tula Pharmaceutical Factory, LLC (Russia)]
Rectal suppositories 100 mg: 10 pcs.

Marketing Authorization Holder

Tula Pharmaceutical Factory, LLC (Russia)

Dosage Form

Novocaine

Rectal suppositories 100 mg: 10 pcs.

Dosage Form, Packaging, and Composition

Rectal suppositories white or white with a yellowish tint, torpedo-shaped.

	1 supp.
Procaine hydrochloride	100 mg

Excipients: hard fat (Witepsol (grades H15, W35), Suppocire (grades NA15, NAS50)) – to obtain a suppository weighing 1.2 g.

5 pcs. – contour cell packs (2) – cardboard packs.

Novocaine [Usolye-Sibirskiy Chemical and Pharmaceutical Plant, JSC (Russia)]
Rectal suppositories 100 mg: 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 pcs.

Marketing Authorization Holder

Usolye-Sibirskiy Chemical and Pharmaceutical Plant, JSC (Russia)

Dosage Form

Novocaine

Rectal suppositories 100 mg: 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 pcs.

Dosage Form, Packaging, and Composition

Rectal suppositories torpedo-shaped, white or white with a yellowish or creamy tint.

	1 supp.
Procaine hydrochloride	100 mg

Excipients: hard fat (Witepsol grade H 15, Suppocire grade NA 15) – 825 mg, hard fat (Witepsol grade W 35, Suppocire grade NAS 50) – 275 mg.

5 pcs. – contour cell packs (1) – cardboard packs.
5 pcs. – contour cell packs (2) – cardboard packs.
5 pcs. – contour cell packs (3) – cardboard packs.
5 pcs. – contour cell packs (4) – cardboard packs.
5 pcs. – contour cell packs (5) – cardboard packs.
5 pcs. – contour cell packs (6) – cardboard packs.
5 pcs. – contour cell packs (7) – cardboard packs.
5 pcs. – contour cell packs (8) – cardboard packs.
5 pcs. – contour cell packs (9) – cardboard packs.
5 pcs. – contour cell packs (10) – cardboard packs.

Novocaine [Pharmasintez, JSC (Russia)]
Solution for injection 2.5 mg/1 ml: amp. 2 ml, 5 ml, or 10 ml 10 pcs.

Marketing Authorization Holder

Pharmasintez, JSC (Russia)

Dosage Form

Novocaine

Solution for injection 2.5 mg/1 ml: amp. 2 ml, 5 ml, or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection as a clear, colorless or slightly colored liquid.

	1 ml
Procaine hydrochloride	2.5 mg

Excipients: hydrochloric acid 0.1M solution – to pH 3.8-4.5, water for injection – to 1 ml.

2 ml – ampoules (10) – cassettes (1) – cardboard packs.
5 ml – ampoules (10) – cassettes (1) – cardboard packs.
10 ml – ampoules (10) – cassettes (1) – cardboard packs.

Novocaine [Pharmasintez, JSC (Russia)]
Solution for injection 5 mg/1 ml: amp. 2 ml, 5 ml, or 10 ml 10 pcs.

Marketing Authorization Holder

Pharmasintez, JSC (Russia)

Dosage Form

Novocaine

Solution for injection 5 mg/1 ml: amp. 2 ml, 5 ml, or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection as a clear, colorless or slightly colored liquid.

	1 ml
Procaine hydrochloride	5 mg

Excipients: hydrochloric acid 0.1M solution – to pH 3.8-4.5, water for injection – to 1 ml.

2 ml – ampoules (10) – cassettes (1) – cardboard packs.
5 ml – ampoules (10) – cassettes (1) – cardboard packs.
10 ml – ampoules (10) – cassettes (1) – cardboard packs.

Novocaine [Pharmasintez, JSC (Russia)]
Solution for injection 10 mg/1 ml: amp. 2 ml, 5 ml, or 10 ml 10 pcs.

Marketing Authorization Holder

Pharmasintez, JSC (Russia)

Dosage Form

Novocaine

Solution for injection 10 mg/1 ml: amp. 2 ml, 5 ml, or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection as a clear, colorless or slightly colored liquid.

	1 ml
Procaine hydrochloride	10 mg

Excipients: hydrochloric acid 0.1M solution – to pH 3.8-4.5, water for injection – to 1 ml.

2 ml – ampoules (10) – cassettes (1) – cardboard packs.
5 ml – ampoules (10) – cassettes (1) – cardboard packs.
10 ml – ampoules (10) – cassettes (1) – cardboard packs.

Novocaine [Pharmasintez, JSC (Russia)]
Solution for injection 20 mg/1 ml: amp. 2 ml, 5 ml, or 10 ml 10 pcs.

Marketing Authorization Holder

Pharmasintez, JSC (Russia)

Dosage Form

Novocaine

Solution for injection 20 mg/1 ml: amp. 2 ml, 5 ml, or 10 ml 10 pcs.

Dosage Form, Packaging, and Composition

Solution for injection as a clear, colorless or slightly colored liquid.

	1 ml
Procaine hydrochloride	20 mg

Solution for injection clear, colorless.

	1 ml
Procaine hydrochloride	5 mg

Excipients: hydrochloric acid 0.1 M solution to pH 3.8-4.5, water for injection to 1 L.

100 ml – blood substitute bottles (1) – cardboard packs.
200 ml – blood substitute bottles (1) – cardboard packs.
400 ml – blood substitute bottles (1) – cardboard packs.
100 ml – blood substitute bottles (28) – cardboard boxes (for hospitals).
200 ml – blood substitute bottles (28) – cardboard boxes (for hospitals).
400 ml – blood substitute bottles (15) – cardboard boxes (for hospitals).

Novocaine [Mir Chemical and Pharmaceutical Concern, LLC (Russia)]
Injection solution 0.25%: 100 ml, 200 ml or 400 ml bottle

Marketing Authorization Holder

Mir Chemical and Pharmaceutical Concern, LLC (Russia)

Dosage Form

Novocaine

Injection solution 0.25%: 100 ml, 200 ml or 400 ml bottle

Dosage Form, Packaging, and Composition

Solution for injection clear, colorless.

	1 ml
Procaine hydrochloride	2.5 mg

Excipients: hydrochloric acid 0.1 M solution to pH 3.8-4.5, water for injection to 1 L.

Medixlife (Author)

View all posts Profile link