Piperazine (Tablets) Instructions for Use

ATC Code

P02CB01 (Piperazine)

Active Substance

Piperazine adipate (Ph.Eur. European Pharmacopoeia)

Clinical-Pharmacological Group

Anthelmintic drug

Pharmacotherapeutic Group

Anthelmintic agent

Pharmacological Action

Anthelmintic agent. It has a paralyzing effect on nematodes, disrupting the function of their neuromuscular system, and causes paralysis of the musculature.

Pharmacokinetics

Piperazine adipate is rapidly absorbed from the gastrointestinal tract. It is excreted from the body mainly by the kidneys.

Indications

• Ascariasis
• Enterobiasis

Use only for infections confirmed by a physician. The choice of agent depends on the identified helminth species.

Adhere strictly to the prescribed treatment regimen and duration to ensure eradication of the parasite and prevent recurrence.

ICD codes

Dosage Regimen

Administer orally. The specific dose and duration are determined by the indication and patient age.

For ascariasis, a single daily dose for 2 consecutive days is typical. For enterobiasis, treatment cycles may be repeated after a 7-day interval.

Follow the prescribed schedule precisely. Tablets are usually taken once daily, with or without food. Adhere to the complete course of therapy even if symptoms improve.

Tablets

For oral administration. The dose, regimen, and duration of therapy are determined individually, depending on the indications, the patient’s age, and the dosage form used.

Adverse Reactions

Gastrointestinal disturbances such as nausea, vomiting, and abdominal pain may occur. Neurological effects like headache and dizziness are also possible.

In patients with pre-existing renal impairment, severe neurotoxicity can develop, manifesting as muscle weakness, tremor, ataxia, visual disturbances, and hallucinations.

Discontinue use and seek medical attention if severe or persistent adverse reactions occur. Allergic skin reactions are also possible.

Contraindications

• Hypersensitivity to piperazine adipate or any component of the formulation.
• Presence of organic diseases of the central nervous system.
• Chronic renal failure or significant renal impairment.
• Pregnancy and lactation (breastfeeding).
• Children under 3 years of age for specific dosage forms.

Do not administer to patients with a history of seizures or epilepsy. Avoid use in individuals with severe hepatic impairment.

Drug Interactions

Concomitant use with chlorpromazine and other phenothiazines is contraindicated due to the risk of potentiating extrapyramidal effects and seizures.

Exercise caution with other neuroactive drugs, such as pyrantel pamoate, as concurrent use may antagonize the anthelmintic effect. Inform your physician of all concomitant medications.

Overdose

Symptoms of overdose are primarily neurological and may include nausea, vomiting, tremor, muscle weakness, ataxia, and visual hallucinations. Severe intoxication can lead to respiratory depression and seizures.

Treatment is symptomatic and supportive. There is no specific antidote. Gastric lavage may be considered. In cases of renal impairment, dialysis may be effective due to the drug’s renal excretion.

Use in Pregnancy and Lactation

Contraindicated for use during pregnancy and lactation (breastfeeding).

Use in Renal Impairment

Contraindicated in chronic renal failure.

Pediatric Use

Use in children is possible according to indications, in age-appropriate recommended doses and dosage forms. It is necessary to strictly follow the instructions in the prescribing information for piperazine adipate preparations regarding contraindications for the use of specific dosage forms of piperazine adipate in children of different ages.

Special Precautions

The use of piperazine adipate does not require preliminary preparation of patients or the prescription of a special diet. Laxatives are prescribed only in cases of a tendency to constipation (in the evenings on the days of piperazine intake).

When treating enterobiasis, strict adherence to a hygiene regimen is necessary.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.